Magnesium inhibits arterial thrombi after vascular injury in rat: In vivo impairment of coagulation

L. Mussoni, L. Sironi, L. Tedeschi, A. M. Calvio, S. Colli, E. Tremoli

Research output: Contribution to journalArticle

Abstract

Magnesium deficiency is associated with a high frequency of cardiac arrhythmia, hypertension and sudden ischemic death. We investigated the in vivo effects of intravenous magnesium administration in a rat model of chemically induced (FeCl3) carotid thrombosis. The infusion of magnesium sulfate (MgSO4) before the topical application of FeCl3 prevented thrombus formation at concentrations of 0.3 M and 0.6 M, and delayed it even at 0.15 M. Similar results were obtained with MgCl2. The infusion of MgSO4 0.6 M seven minutes after FeCl3 application delayed but did not prevent thrombus formation. MgSO4 slightly reduced platelet aggregation ex vivo without affecting plasma clotting tests, but in vivo blood clotting time was markedly prolonged (tail transection method), thus indicating profoundly impaired coagulation. These data provide a rationale for the use of magnesium as an anti-thrombotic agent, but its pharmacological effect critically depends on the timing of administration.

Original languageEnglish
Pages (from-to)1292-1295
Number of pages4
JournalThrombosis and Haemostasis
Volume86
Issue number5
Publication statusPublished - 2001

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Keywords

  • Animal model
  • Coagulation
  • Magnesium
  • Platelets
  • Thrombosis

ASJC Scopus subject areas

  • Hematology

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