Magnesium metabolism in chronic alcohol-use disorder: Meta-analysis and systematic review

Flora O. Vanoni, Gregorio P. Milani, Carlo Agostoni, Giorgio Treglia, Pietro B. Faré, Pietro Camozzi, Sebastiano A.G. Lava, Mario G. Bianchetti, Simone Janett

Research output: Contribution to journalArticlepeer-review


Chronic alcohol-use disorder has been imputed as a possible cause of dietary magnesium depletion. The purpose of this study was to assess the prevalence of hypomagnesemia in chronic alcohol-use disorder, and to provide information on intracellular magnesium and on its renal handling. We carried out a structured literature search up to November 2020, which returned 2719 potentially relevant records. After excluding non-significant records, 25 were retained for the final analysis. The meta-analysis disclosed that both total and ionized circulating magnesium are markedly reduced in chronic alcohol-use disorder. The funnel plot and the Egger’s test did not disclose significant publication bias. The I2-test demonstrated significant statistical heterogeneity between studies. We also found that the skeletal muscle magnesium content is reduced and the kidney’s normal response to hypomagnesemia is blunted. In conclusion, magnesium depletion is common in chronic alcohol-use disorder. Furthermore, the kidney plays a crucial role in the development of magnesium depletion.

Original languageEnglish
Article number1959
Issue number6
Publication statusPublished - Jun 2021


  • Alcohol-use
  • Depletion
  • Diet
  • Electrolytes
  • Hypomagnesemia
  • Kidney
  • Magnesium

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics


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