Magnetic hydroxyapatite coatings as a new tool in medicine: A scanning probe investigation

A. Gambardella, M. Bianchi, S. Kaciulis, A. Mezzi, M. Brucale, M. Cavallini, T. Herrmannsdoerfer, G. Chanda, M. Uhlarz, A. Cellini, M. F. Pedna, V. Sambri, M. Marcacci, A. Russo

Research output: Contribution to journalArticle

Abstract

Hydroxyapatite films enriched with magnetite have been fabricated via a Pulsed Plasma Deposition (PPD) system with the final aim of representing a new platform able to disincentivate bacterial adhesion and biofilm formation. The chemical composition and magnetic properties of films were respectively examined by X-ray photoelectron spectroscopy (XPS) and Superconducting Quantum Interference Device (SQUID) measurements. The morphology and conductive properties of the magnetic films were investigated via a combination of scanning probe technologies including atomic force microscopy (AFM), electrostatic force microscopy (EFM), and scanning tunneling microscopy (STM). Interestingly, the range of adopted techniques allowed determining the preservation of the chemical composition and magnetic properties of the deposition target material while STM analysis provided new insights on the presence of surface inhomogeneities, revealing the presence of magnetite-rich islands over length scales compatible with the applications. Finally, preliminary results of bacterial adhesion tests, indicated a higher ability of magnetic hydroxyapatite films to reduce Escherichia coli adhesion at 4 h from seeding compared to control hydroxyapatite films.

Original languageEnglish
Pages (from-to)444-449
Number of pages6
JournalMaterials Science and Engineering C
Volume62
DOIs
Publication statusPublished - May 1 2016

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Keywords

  • Escherichia coli adhesion
  • Magnetic biomaterials
  • Nanomedicine
  • Percolation
  • Scanning probes
  • Tissue engineering

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering
  • Mechanics of Materials

Cite this

Gambardella, A., Bianchi, M., Kaciulis, S., Mezzi, A., Brucale, M., Cavallini, M., Herrmannsdoerfer, T., Chanda, G., Uhlarz, M., Cellini, A., Pedna, M. F., Sambri, V., Marcacci, M., & Russo, A. (2016). Magnetic hydroxyapatite coatings as a new tool in medicine: A scanning probe investigation. Materials Science and Engineering C, 62, 444-449. https://doi.org/10.1016/j.msec.2016.01.071