Magnetic resonance and single-photon emission tomography findings in a pair of twins discordant for Alzheimer's disease

Cristina Geroldi, Giovanni B. Frisoni, Alberto Beltramello, Claudia Weiss, Angelo Bianchetti, Gilberto Pizzolato, Giorgio Ferlin, Marco Trabucchi

Research output: Contribution to journalArticle

Abstract

The value of functional and morphological neuroimaging in the early diagnosis of Alzheimer's disease (AD) is still debated. Described here are cerebral perfusion and linear measures of medial temporal lobe atrophy in 2 monozygotic twins discordant for AD who were investigated with technetium 99m-hexamethylpropyleneamineoxime single-photon emission tomography (SPET) and magnetic resonance (MR) imaging. Both showed pathological cortical perfusion findings on SPET, while medial temporal lobe atrophy was present only in the affected twin. MR measures of medial temporal lobe atrophy have greater agreement with clinical data than do SPET measures of cerebral perfusion. Evaluation of atrophy may be useful in the early diagnosis of AD.

Original languageEnglish
Pages (from-to)76-80
Number of pages5
JournalJournal of Neuroimaging
Volume6
Issue number2
Publication statusPublished - 1996

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ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology
  • Neuroscience(all)
  • Radiological and Ultrasound Technology

Cite this

Geroldi, C., Frisoni, G. B., Beltramello, A., Weiss, C., Bianchetti, A., Pizzolato, G., Ferlin, G., & Trabucchi, M. (1996). Magnetic resonance and single-photon emission tomography findings in a pair of twins discordant for Alzheimer's disease. Journal of Neuroimaging, 6(2), 76-80.