Magnetic resonance imaging: A new tool for diagnosis of acute ischemic colitis?

Francesca Iacobellis, Daniela Berritto, Francesco Somma, Carlo Cavaliere, Marco Corona, Santolo Cozzolino, Franco Fulciniti, Salvatore Cappabianca, Antonio Rotondo, Roberto Grassi

Research output: Contribution to journalArticle

Abstract

AIM: To define the evolution of ischemic lesions with 7T magnetic resonance imaging (7T-MRI) in an animal model of acute colonic ischemia. METHODS: Adult Sprague-Dawley rats were divided into two groups. Group II underwent inferior mesenteric artery (IMA) ligation followed by macroscopic observations and histological analysis. In group II, 7T-MRI was performed before and after IMA ligation and followed by histological analysis. RESULTS: Morphological alterations started to develop 1 h after IMA ligation, when pale areas became evident in the splenic flexure mesentery and progressively worsened up to 8 h thereafter, when the mesentery was less pale, and the splenic flexure loop appeared very dark. The 7T-MRI results reflected these alterations, showing a hyperintense signal in both the intraperitoneal space and the colonic loop wall 1 h after IMA ligation; the latter progressively increased to demonstrate a reduction in the colonic loop lumen at 6 h. Eight hours after IMA ligation, MRI showed a persistent colonic mural hyperintensity associated with a reduction in peritoneal free fluid. The 7T-MRI findings were correlated with histological alterations, varying from an attenuated epithelium with glandular apex lesions at 1 h to coagulative necrosis and loss of the surface epithelium detected 8 h after IMA ligation. CONCLUSION: MRI may be used as a substitute for invasive procedures in diagnosing and grading acute ischemic colitis, allowing for the early identification of pathological findings.

Original languageEnglish
Pages (from-to)1496-1501
Number of pages6
JournalWorld Journal of Gastroenterology
Volume18
Issue number13
DOIs
Publication statusPublished - Apr 7 2012

Keywords

  • Animal models
  • Histopathology
  • Ischemic colitis
  • Magnetic resonance imaging
  • Sprague- Dawley rats

ASJC Scopus subject areas

  • Gastroenterology

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  • Cite this

    Iacobellis, F., Berritto, D., Somma, F., Cavaliere, C., Corona, M., Cozzolino, S., Fulciniti, F., Cappabianca, S., Rotondo, A., & Grassi, R. (2012). Magnetic resonance imaging: A new tool for diagnosis of acute ischemic colitis? World Journal of Gastroenterology, 18(13), 1496-1501. https://doi.org/10.3748/wjg.v18.i13.1496