Magnetic resonance imaging: A new tool for diagnosis of acute ischemic colitis?

Francesca Iacobellis, Daniela Berritto, Francesco Somma, Carlo Cavaliere, Marco Corona, Santolo Cozzolino, Franco Fulciniti, Salvatore Cappabianca, Antonio Rotondo, Roberto Grassi

Research output: Contribution to journalArticle

Abstract

AIM: To define the evolution of ischemic lesions with 7T magnetic resonance imaging (7T-MRI) in an animal model of acute colonic ischemia. METHODS: Adult Sprague-Dawley rats were divided into two groups. Group II underwent inferior mesenteric artery (IMA) ligation followed by macroscopic observations and histological analysis. In group II, 7T-MRI was performed before and after IMA ligation and followed by histological analysis. RESULTS: Morphological alterations started to develop 1 h after IMA ligation, when pale areas became evident in the splenic flexure mesentery and progressively worsened up to 8 h thereafter, when the mesentery was less pale, and the splenic flexure loop appeared very dark. The 7T-MRI results reflected these alterations, showing a hyperintense signal in both the intraperitoneal space and the colonic loop wall 1 h after IMA ligation; the latter progressively increased to demonstrate a reduction in the colonic loop lumen at 6 h. Eight hours after IMA ligation, MRI showed a persistent colonic mural hyperintensity associated with a reduction in peritoneal free fluid. The 7T-MRI findings were correlated with histological alterations, varying from an attenuated epithelium with glandular apex lesions at 1 h to coagulative necrosis and loss of the surface epithelium detected 8 h after IMA ligation. CONCLUSION: MRI may be used as a substitute for invasive procedures in diagnosing and grading acute ischemic colitis, allowing for the early identification of pathological findings.

Original languageEnglish
Pages (from-to)1496-1501
Number of pages6
JournalWorld Journal of Gastroenterology
Volume18
Issue number13
DOIs
Publication statusPublished - Apr 7 2012

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Inferior Mesenteric Artery
Ischemic Colitis
Ligation
Magnetic Resonance Imaging
Transverse Colon
Mesentery
Epithelium
Ascitic Fluid
Sprague Dawley Rats
Necrosis
Ischemia
Animal Models

Keywords

  • Animal models
  • Histopathology
  • Ischemic colitis
  • Magnetic resonance imaging
  • Sprague- Dawley rats

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Iacobellis, F., Berritto, D., Somma, F., Cavaliere, C., Corona, M., Cozzolino, S., ... Grassi, R. (2012). Magnetic resonance imaging: A new tool for diagnosis of acute ischemic colitis? World Journal of Gastroenterology, 18(13), 1496-1501. https://doi.org/10.3748/wjg.v18.i13.1496

Magnetic resonance imaging : A new tool for diagnosis of acute ischemic colitis? / Iacobellis, Francesca; Berritto, Daniela; Somma, Francesco; Cavaliere, Carlo; Corona, Marco; Cozzolino, Santolo; Fulciniti, Franco; Cappabianca, Salvatore; Rotondo, Antonio; Grassi, Roberto.

In: World Journal of Gastroenterology, Vol. 18, No. 13, 07.04.2012, p. 1496-1501.

Research output: Contribution to journalArticle

Iacobellis, F, Berritto, D, Somma, F, Cavaliere, C, Corona, M, Cozzolino, S, Fulciniti, F, Cappabianca, S, Rotondo, A & Grassi, R 2012, 'Magnetic resonance imaging: A new tool for diagnosis of acute ischemic colitis?', World Journal of Gastroenterology, vol. 18, no. 13, pp. 1496-1501. https://doi.org/10.3748/wjg.v18.i13.1496
Iacobellis, Francesca ; Berritto, Daniela ; Somma, Francesco ; Cavaliere, Carlo ; Corona, Marco ; Cozzolino, Santolo ; Fulciniti, Franco ; Cappabianca, Salvatore ; Rotondo, Antonio ; Grassi, Roberto. / Magnetic resonance imaging : A new tool for diagnosis of acute ischemic colitis?. In: World Journal of Gastroenterology. 2012 ; Vol. 18, No. 13. pp. 1496-1501.
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