Magnetic resonance imaging and ultrasound evaluation of "healthy" joints in young subjects with severe haemophilia A

M. N D Di Minno, S. Iervolino, E. Soscia, A. Tosetto, A. Coppola, M. Schiavulli, E. Marrone, C. Ruosi, M. Salvatore, G. Di Minno

Research output: Contribution to journalArticle

Abstract

Magnetic resonance imaging (MRI) and ultrasonography (US) are increasingly used in haemophilia A (HA) to detect early joint changes. A total of 40 clinically asymptomatic joints, never involved by bleeding events ["healthy joints" (HJ)], were evaluated by MRI and, in parallel, by US in 20 young subjects with severe HA (22.45 ± 2.72 years old; no history of arthritides, of viral infections or of inhibitors against factor VIII). The same joints were evaluated in 20 matched non-haemophilic (no-HA) subjects (mean age 23.90 ± 2.31 years, P = 0.078 vs. HA subjects). US images were obtained with specific probe positions according to validated procedures. A validated US score and progressive (P-MRI) and additive (A-MRI) MRI scores were employed for data collection and analysis. The US score was higher in HA than in no-HA subjects (3.40 ± 1.72 vs. 0.80 ± 1.10, P <0.001). Taking into account only moderate/severe alterations, joint effusion was found in 55% of HA and in 5% of no-HA joints (P <0.001); synovial hypertrophy was found in 20% of HA and in none of the no-HA joints; cartilage erosion was found in 30% of HA and in none of no-HA joints. MRI examinations confirmed these findings and the US score correlated with the A-MRI (r = 0.732, P <0.001) and with the P-MRI (r = 0.598, P <0.001) scores. MRI and US data significantly correlated as to effusion (r = 0.819, P = 0.002), synovial hypertrophy (r = 0.633, P = 0.036) and cartilage erosion (r = 0.734, P = 0.010). Despite inherent limitations, joint US examination identified subclinical abnormalities of HJ in young subjects with severe HA.

Original languageEnglish
JournalHaemophilia
Volume19
Issue number3
DOIs
Publication statusPublished - May 2013

Fingerprint

Hemophilia A
Joints
Ultrasonography
Magnetic Resonance Imaging
Synovitis
Cartilage
Factor VIII
Virus Diseases
Arthritis
Hemorrhage

Keywords

  • Arthropathy
  • Early lesions
  • Haemophilia
  • Magnetic resonance imaging
  • Ultrasound

ASJC Scopus subject areas

  • Hematology
  • Genetics(clinical)

Cite this

Di Minno, M. N. D., Iervolino, S., Soscia, E., Tosetto, A., Coppola, A., Schiavulli, M., ... Di Minno, G. (2013). Magnetic resonance imaging and ultrasound evaluation of "healthy" joints in young subjects with severe haemophilia A. Haemophilia, 19(3). https://doi.org/10.1111/hae.12107

Magnetic resonance imaging and ultrasound evaluation of "healthy" joints in young subjects with severe haemophilia A. / Di Minno, M. N D; Iervolino, S.; Soscia, E.; Tosetto, A.; Coppola, A.; Schiavulli, M.; Marrone, E.; Ruosi, C.; Salvatore, M.; Di Minno, G.

In: Haemophilia, Vol. 19, No. 3, 05.2013.

Research output: Contribution to journalArticle

Di Minno, MND, Iervolino, S, Soscia, E, Tosetto, A, Coppola, A, Schiavulli, M, Marrone, E, Ruosi, C, Salvatore, M & Di Minno, G 2013, 'Magnetic resonance imaging and ultrasound evaluation of "healthy" joints in young subjects with severe haemophilia A', Haemophilia, vol. 19, no. 3. https://doi.org/10.1111/hae.12107
Di Minno, M. N D ; Iervolino, S. ; Soscia, E. ; Tosetto, A. ; Coppola, A. ; Schiavulli, M. ; Marrone, E. ; Ruosi, C. ; Salvatore, M. ; Di Minno, G. / Magnetic resonance imaging and ultrasound evaluation of "healthy" joints in young subjects with severe haemophilia A. In: Haemophilia. 2013 ; Vol. 19, No. 3.
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abstract = "Magnetic resonance imaging (MRI) and ultrasonography (US) are increasingly used in haemophilia A (HA) to detect early joint changes. A total of 40 clinically asymptomatic joints, never involved by bleeding events [{"}healthy joints{"} (HJ)], were evaluated by MRI and, in parallel, by US in 20 young subjects with severe HA (22.45 ± 2.72 years old; no history of arthritides, of viral infections or of inhibitors against factor VIII). The same joints were evaluated in 20 matched non-haemophilic (no-HA) subjects (mean age 23.90 ± 2.31 years, P = 0.078 vs. HA subjects). US images were obtained with specific probe positions according to validated procedures. A validated US score and progressive (P-MRI) and additive (A-MRI) MRI scores were employed for data collection and analysis. The US score was higher in HA than in no-HA subjects (3.40 ± 1.72 vs. 0.80 ± 1.10, P <0.001). Taking into account only moderate/severe alterations, joint effusion was found in 55{\%} of HA and in 5{\%} of no-HA joints (P <0.001); synovial hypertrophy was found in 20{\%} of HA and in none of the no-HA joints; cartilage erosion was found in 30{\%} of HA and in none of no-HA joints. MRI examinations confirmed these findings and the US score correlated with the A-MRI (r = 0.732, P <0.001) and with the P-MRI (r = 0.598, P <0.001) scores. MRI and US data significantly correlated as to effusion (r = 0.819, P = 0.002), synovial hypertrophy (r = 0.633, P = 0.036) and cartilage erosion (r = 0.734, P = 0.010). Despite inherent limitations, joint US examination identified subclinical abnormalities of HJ in young subjects with severe HA.",
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AU - Iervolino, S.

AU - Soscia, E.

AU - Tosetto, A.

AU - Coppola, A.

AU - Schiavulli, M.

AU - Marrone, E.

AU - Ruosi, C.

AU - Salvatore, M.

AU - Di Minno, G.

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