Magnetic resonance imaging as predictor of functional outcome in craniopharyngiomas

Pietro Mortini, Filippo Gagliardi, Michele Bailo, Alfio Spina, Andrea Parlangeli, Andrea Falini, Marco Losa

Research output: Contribution to journalArticle

Abstract

Quality of life of craniopharyngioma patients can be severely impaired by derangement of hypothalamic function. A classification, taking into account preoperative hypothalamic damage, evaluated by magnetic resonance imaging (MRI), and correlating it with postoperative weight change is still missing in the literature. The aim of our study is to identify objective radiological criteria as preoperative prognostic factors for hypothalamic damage. Pre- and post-operative MRI and clinical data of 47 patients, treated at our Institution for craniopharyngioma, were retrospectively analyzed, based on radiological variables, identified as prognostic factor for hypothalamic involvement. Main factors associated with postoperative obesity were hypothalamic hyperintensity in T2-weighted/FLAIR imaging (p 

Original languageEnglish
Pages (from-to)148-162
Number of pages15
JournalEndocrine
Volume51
Issue number1
DOIs
Publication statusPublished - Jan 1 2016

Keywords

  • Clinical outcome
  • Craniopharyngioma
  • Hypothalamus
  • MRI

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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