Correlatos de los estudios de resonancia magnetica nuclear con la disfuncion cognitiva observada en pacientes con esclerosis multiple

Translated title of the contribution: Magnetic resonance imaging correlates of cognitive dysfunction in patients with multiple sclerosis

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Introduction and development. Studies with conventional magnetic resonance imaging (MRI) support the hypothesis that cognitive impairment in multiple sclerosis (MS) patients is related with the lesion burden. Patterns of frontal lobe cognitive decline were also found to be related with the corresponding regional lesion load, although the total lesion load on T 2-weighted MRI scans of the brain seems to be more relevant in determining frontal lobe deficits. Other non-conventional MRI techniques with a higher specificity to the heterogeneous substrates of MS pathology, such as the assessment of hypointense lesion load on T 1-weighted scans and the histogram analysis of magnetization transfer ratio maps, have recently been applied to MS cognitive studies. Conclusions. Results from these studies suggest that three factors play a role in the pathogenesis of MS dementia: the burden of MS lesions, the severity of the pathological damage within individual lesions and that of the normal-appearing white matter.

Original languageSpanish
Pages (from-to)1253-1256
Number of pages4
JournalRevista de Neurologia
Volume30
Issue number12
Publication statusPublished - Jun 16 2000

Fingerprint

Multiple Sclerosis
Magnetic Resonance Imaging
Frontal Lobe
Dementia
Cognitive Dysfunction
Pathology
Brain

Keywords

  • Cognitive functions
  • Frontal lobe
  • Magnetic resonance imaging
  • Magnetization transfer imaging
  • Multiple sclerosis

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

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abstract = "Introduction and development. Studies with conventional magnetic resonance imaging (MRI) support the hypothesis that cognitive impairment in multiple sclerosis (MS) patients is related with the lesion burden. Patterns of frontal lobe cognitive decline were also found to be related with the corresponding regional lesion load, although the total lesion load on T 2-weighted MRI scans of the brain seems to be more relevant in determining frontal lobe deficits. Other non-conventional MRI techniques with a higher specificity to the heterogeneous substrates of MS pathology, such as the assessment of hypointense lesion load on T 1-weighted scans and the histogram analysis of magnetization transfer ratio maps, have recently been applied to MS cognitive studies. Conclusions. Results from these studies suggest that three factors play a role in the pathogenesis of MS dementia: the burden of MS lesions, the severity of the pathological damage within individual lesions and that of the normal-appearing white matter.",
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