Magnetic resonance imaging markers of Parkinson's disease nigrostriatal signature

Patrice Péran, Andrea Cherubini, Francesca Assogna, Fabrizio Piras, Carlo Quattrocchi, Antonella Peppe, Pierre Celsis, Olivier Rascol, Jean Franois Démonet, Alessandro Stefani, Mariangela Pierantozzi, Francesco Ernesto Pontieri, Carlo Caltagirone, Gianfranco Spalletta, Umberto Sabatini

Research output: Contribution to journalArticle

243 Citations (Scopus)

Abstract

One objective of modern neuroimaging is to identify markers that can aid in diagnosis, disease progression monitoring and long-term drug impact analysis. In this study, Parkinson-associated physiopathological modifications were characterized in six subcortical structures by simultaneously measuring quantitative magnetic resonance parameters sensitive to complementary tissue characteristics (i.e. volume atrophy, iron deposition and microstructural damage). Thirty patients with Parkinson's disease and 22 control subjects underwent 3-T magnetic resonance imaging with T2*-weighted, whole-brain T1-weighted and diffusion tensor imaging scans. The mean R2* value, mean diffusivity and fractional anisotropy in the pallidum, putamen, caudate nucleus, thalamus, substantia nigra and red nucleus were compared between patients with Parkinson's disease and control subjects. Comparisons were also performed using voxel-based analysis of R2*, mean diffusivity and fractional anisotropy maps to determine which subregion of the basal ganglia showed the greater difference for each parameter. Averages of each subregion were then used in a logistic regression analysis. Compared with control subjects, patients with Parkinson's disease displayed significantly higher R2* values in the substantia nigra, lower fractional anisotropy values in the substantia nigra and thalamus, and higher mean diffusivity values in the thalamus. Voxel-based analyses confirmed these results and, in addition, showed a significant difference in the mean diffusivity in the striatum. The combination of three markers was sufficient to obtain a 95 global accuracy (area under the receiver operating characteristic curve) for discriminating patients with Parkinson's disease from controls. The markers comprising discriminating combinations were R2* in the substantia nigra, fractional anisotropy in the substantia nigra and mean diffusivity in the putamen or caudate nucleus. Remarkably, the predictive markers involved the nigrostriatal structures that characterize Parkinson's physiopathology. Furthermore, highly discriminating combinations included markers from three different magnetic resonance parameters (R2*, mean diffusivity and fractional anisotropy). These findings demonstrate that multimodal magnetic resonance imaging of subcortical grey matter structures is useful for the evaluation of Parkinson's disease and, possibly, of other subcortical pathologies.

Original languageEnglish
Pages (from-to)3423-3433
Number of pages11
JournalBrain
Volume133
Issue number11
DOIs
Publication statusPublished - Nov 2010

Fingerprint

Anisotropy
Substantia Nigra
Parkinson Disease
Magnetic Resonance Imaging
Thalamus
Caudate Nucleus
Putamen
Magnetic Resonance Spectroscopy
Red Nucleus
Globus Pallidus
Diffusion Tensor Imaging
Basal Ganglia
Neuroimaging
ROC Curve
Atrophy
Disease Progression
Iron
Logistic Models
Regression Analysis
Pathology

Keywords

  • anisotropy
  • iron
  • mean diffusivity
  • MRI
  • parkinsonism

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Péran, P., Cherubini, A., Assogna, F., Piras, F., Quattrocchi, C., Peppe, A., ... Sabatini, U. (2010). Magnetic resonance imaging markers of Parkinson's disease nigrostriatal signature. Brain, 133(11), 3423-3433. https://doi.org/10.1093/brain/awq212

Magnetic resonance imaging markers of Parkinson's disease nigrostriatal signature. / Péran, Patrice; Cherubini, Andrea; Assogna, Francesca; Piras, Fabrizio; Quattrocchi, Carlo; Peppe, Antonella; Celsis, Pierre; Rascol, Olivier; Démonet, Jean Franois; Stefani, Alessandro; Pierantozzi, Mariangela; Pontieri, Francesco Ernesto; Caltagirone, Carlo; Spalletta, Gianfranco; Sabatini, Umberto.

In: Brain, Vol. 133, No. 11, 11.2010, p. 3423-3433.

Research output: Contribution to journalArticle

Péran, P, Cherubini, A, Assogna, F, Piras, F, Quattrocchi, C, Peppe, A, Celsis, P, Rascol, O, Démonet, JF, Stefani, A, Pierantozzi, M, Pontieri, FE, Caltagirone, C, Spalletta, G & Sabatini, U 2010, 'Magnetic resonance imaging markers of Parkinson's disease nigrostriatal signature', Brain, vol. 133, no. 11, pp. 3423-3433. https://doi.org/10.1093/brain/awq212
Péran, Patrice ; Cherubini, Andrea ; Assogna, Francesca ; Piras, Fabrizio ; Quattrocchi, Carlo ; Peppe, Antonella ; Celsis, Pierre ; Rascol, Olivier ; Démonet, Jean Franois ; Stefani, Alessandro ; Pierantozzi, Mariangela ; Pontieri, Francesco Ernesto ; Caltagirone, Carlo ; Spalletta, Gianfranco ; Sabatini, Umberto. / Magnetic resonance imaging markers of Parkinson's disease nigrostriatal signature. In: Brain. 2010 ; Vol. 133, No. 11. pp. 3423-3433.
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