Magnetic resonance imaging (MRI) compared with computed tomography (CT) for interobserver agreement of gross tumor volume delineation in pancreatic cancer: a multi-institutional contouring study on behalf of the AIRO group for gastrointestinal cancers

Luciana Caravatta; Francesco Cellini; Nicola Simoni; Consuelo Rosa; Rita Marina Niespolo; Marco Lupattelli; Vincenzo Picardi; Gabriella Macchia; Aldo Sainato; Giovanna Mantello; Francesco Dionisi; Maria Elena Rosetto; Vincenzo Fusco; Federico Navarria; Antonino De Paoli; Alessandra Guido; Claudio Vecchi; Raffaella Basilico; Roberta Cianci; Andrea Delli Pizzi; Marta Di Nicola; Gian Carlo Mattiucci; Vincenzo Valentini; Alessio Giuseppe Morganti; Domenico Genovesi

doi:10.1080/0284186X.2018.1546899

Magnetic resonance imaging (MRI) compared with computed tomography (CT) for interobserver agreement of gross tumor volume delineation in pancreatic cancer: a multi-institutional contouring study on behalf of the AIRO group for gastrointestinal cancers

Luciana Caravatta, Francesco Cellini, Nicola Simoni, Consuelo Rosa, Rita Marina Niespolo, Marco Lupattelli, Vincenzo Picardi, Gabriella Macchia, Aldo Sainato, Giovanna Mantello, Francesco Dionisi, Maria Elena Rosetto, Vincenzo Fusco, Federico Navarria, Antonino De Paoli, Alessandra Guido, Claudio Vecchi, Raffaella Basilico, Roberta Cianci, Andrea Delli PizziMarta Di Nicola, Gian Carlo Mattiucci, Vincenzo Valentini, Alessio Giuseppe Morganti, Domenico Genovesi

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND: Due to the high soft tissue resolution, magnetic resonance imaging (MRI) could improve the accuracy of pancreatic tumor delineation in radiation treatment planning. A multi-institutional study was proposed to evaluate the impact of MRI on inter-observer agreement in gross tumor volume (GTV) and duodenum delineation for pancreatic cancer compared with computer tomography (CT). MATERIAL AND METHODS: Two clinical cases of borderline resectable (Case 1) and unresectable (Case 2) pancreatic cancer were selected. In two sequential steps, diagnostic contrast-enhanced CT scan and MRI sequences were sent to the participating centers. CT-GTVs were contoured while blinded to MRI data sets. DICE index was used to evaluate the spatial overlap accuracy. RESULTS: Thirty-one radiation oncologists from different Institutions submitted the delineated volumes. CT- and MRI-GTV mean volumes were 21.6 ± 9.0 cm(3) and 17.2 ± 6.0 cm(3), respectively for Case 1, and 31.3 ± 15.6 cm(3) and 33.2 ± 20.2 cm(3), respectively for Case 2. Resulting MRI-GTV mean volume was significantly smaller than CT-GTV in the borderline resectable case (p

Original language	English
Pages (from-to)	439-447
Number of pages	9
Journal	Acta Oncologica
Volume	58
Issue number	4
DOIs	https://doi.org/10.1080/0284186X.2018.1546899
Publication status	Published - Apr 2019

Keywords

Aged
Female
Follow-Up Studies
Gastrointestinal Neoplasms/*diagnostic imaging/*pathology
Humans
Magnetic Resonance Imaging/*methods
Male
*Observer Variation
Pancreatic Neoplasms/*diagnostic imaging/*pathology
Prognosis
Radiotherapy Planning, Computer-Assisted
Retrospective Studies
Tomography, X-Ray Computed/*methods
Tumor Burden

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10.1080/0284186X.2018.1546899

https://pubmed.ncbi.nlm.nih.gov/30632876

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Caravatta, L., Cellini, F., Simoni, N., Rosa, C., Niespolo, R. M., Lupattelli, M., Picardi, V., Macchia, G., Sainato, A., Mantello, G., Dionisi, F., Rosetto, M. E., Fusco, V., Navarria, F., De Paoli, A., Guido, A., Vecchi, C., Basilico, R., Cianci, R., ... Genovesi, D. (2019). Magnetic resonance imaging (MRI) compared with computed tomography (CT) for interobserver agreement of gross tumor volume delineation in pancreatic cancer: a multi-institutional contouring study on behalf of the AIRO group for gastrointestinal cancers. Acta Oncologica, 58(4), 439-447. https://doi.org/10.1080/0284186X.2018.1546899

Magnetic resonance imaging (MRI) compared with computed tomography (CT) for interobserver agreement of gross tumor volume delineation in pancreatic cancer: a multi-institutional contouring study on behalf of the AIRO group for gastrointestinal cancers. / Caravatta, Luciana; Cellini, Francesco; Simoni, Nicola; Rosa, Consuelo; Niespolo, Rita Marina; Lupattelli, Marco; Picardi, Vincenzo; Macchia, Gabriella; Sainato, Aldo; Mantello, Giovanna; Dionisi, Francesco; Rosetto, Maria Elena; Fusco, Vincenzo ; Navarria, Federico; De Paoli, Antonino; Guido, Alessandra; Vecchi, Claudio; Basilico, Raffaella; Cianci, Roberta; Delli Pizzi, Andrea; Di Nicola, Marta; Mattiucci, Gian Carlo ; Valentini, Vincenzo; Morganti, Alessio Giuseppe; Genovesi, Domenico.

In: Acta Oncologica, Vol. 58, No. 4, 04.2019, p. 439-447.

Research output: Contribution to journal › Article › peer-review

Caravatta, L, Cellini, F, Simoni, N, Rosa, C, Niespolo, RM, Lupattelli, M, Picardi, V, Macchia, G, Sainato, A, Mantello, G, Dionisi, F, Rosetto, ME, Fusco, V , Navarria, F, De Paoli, A, Guido, A, Vecchi, C, Basilico, R, Cianci, R, Delli Pizzi, A, Di Nicola, M, Mattiucci, GC , Valentini, V, Morganti, AG & Genovesi, D 2019, 'Magnetic resonance imaging (MRI) compared with computed tomography (CT) for interobserver agreement of gross tumor volume delineation in pancreatic cancer: a multi-institutional contouring study on behalf of the AIRO group for gastrointestinal cancers', Acta Oncologica, vol. 58, no. 4, pp. 439-447. https://doi.org/10.1080/0284186X.2018.1546899

Caravatta L, Cellini F, Simoni N, Rosa C, Niespolo RM, Lupattelli M et al. Magnetic resonance imaging (MRI) compared with computed tomography (CT) for interobserver agreement of gross tumor volume delineation in pancreatic cancer: a multi-institutional contouring study on behalf of the AIRO group for gastrointestinal cancers. Acta Oncologica. 2019 Apr;58(4):439-447. https://doi.org/10.1080/0284186X.2018.1546899

Caravatta, Luciana ; Cellini, Francesco ; Simoni, Nicola ; Rosa, Consuelo ; Niespolo, Rita Marina ; Lupattelli, Marco ; Picardi, Vincenzo ; Macchia, Gabriella ; Sainato, Aldo ; Mantello, Giovanna ; Dionisi, Francesco ; Rosetto, Maria Elena ; Fusco, Vincenzo ; Navarria, Federico ; De Paoli, Antonino ; Guido, Alessandra ; Vecchi, Claudio ; Basilico, Raffaella ; Cianci, Roberta ; Delli Pizzi, Andrea ; Di Nicola, Marta ; Mattiucci, Gian Carlo ; Valentini, Vincenzo ; Morganti, Alessio Giuseppe ; Genovesi, Domenico. / Magnetic resonance imaging (MRI) compared with computed tomography (CT) for interobserver agreement of gross tumor volume delineation in pancreatic cancer: a multi-institutional contouring study on behalf of the AIRO group for gastrointestinal cancers. In: Acta Oncologica. 2019 ; Vol. 58, No. 4. pp. 439-447.

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abstract = "BACKGROUND: Due to the high soft tissue resolution, magnetic resonance imaging (MRI) could improve the accuracy of pancreatic tumor delineation in radiation treatment planning. A multi-institutional study was proposed to evaluate the impact of MRI on inter-observer agreement in gross tumor volume (GTV) and duodenum delineation for pancreatic cancer compared with computer tomography (CT). MATERIAL AND METHODS: Two clinical cases of borderline resectable (Case 1) and unresectable (Case 2) pancreatic cancer were selected. In two sequential steps, diagnostic contrast-enhanced CT scan and MRI sequences were sent to the participating centers. CT-GTVs were contoured while blinded to MRI data sets. DICE index was used to evaluate the spatial overlap accuracy. RESULTS: Thirty-one radiation oncologists from different Institutions submitted the delineated volumes. CT- and MRI-GTV mean volumes were 21.6 ± 9.0 cm(3) and 17.2 ± 6.0 cm(3), respectively for Case 1, and 31.3 ± 15.6 cm(3) and 33.2 ± 20.2 cm(3), respectively for Case 2. Resulting MRI-GTV mean volume was significantly smaller than CT-GTV in the borderline resectable case (p ",

keywords = "Aged, Female, Follow-Up Studies, Gastrointestinal Neoplasms/*diagnostic imaging/*pathology, Humans, Magnetic Resonance Imaging/*methods, Male, *Observer Variation, Pancreatic Neoplasms/*diagnostic imaging/*pathology, Prognosis, Radiotherapy Planning, Computer-Assisted, Retrospective Studies, Tomography, X-Ray Computed/*methods, Tumor Burden",

author = "Luciana Caravatta and Francesco Cellini and Nicola Simoni and Consuelo Rosa and Niespolo, {Rita Marina} and Marco Lupattelli and Vincenzo Picardi and Gabriella Macchia and Aldo Sainato and Giovanna Mantello and Francesco Dionisi and Rosetto, {Maria Elena} and Vincenzo Fusco and Federico Navarria and {De Paoli}, Antonino and Alessandra Guido and Claudio Vecchi and Raffaella Basilico and Roberta Cianci and {Delli Pizzi}, Andrea and {Di Nicola}, Marta and Mattiucci, {Gian Carlo} and Vincenzo Valentini and Morganti, {Alessio Giuseppe} and Domenico Genovesi",

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doi = "10.1080/0284186X.2018.1546899",

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T1 - Magnetic resonance imaging (MRI) compared with computed tomography (CT) for interobserver agreement of gross tumor volume delineation in pancreatic cancer: a multi-institutional contouring study on behalf of the AIRO group for gastrointestinal cancers

AU - Caravatta, Luciana

AU - Cellini, Francesco

AU - Simoni, Nicola

AU - Rosa, Consuelo

AU - Niespolo, Rita Marina

AU - Lupattelli, Marco

AU - Picardi, Vincenzo

AU - Macchia, Gabriella

AU - Sainato, Aldo

AU - Mantello, Giovanna

AU - Dionisi, Francesco

AU - Rosetto, Maria Elena

AU - Fusco, Vincenzo

AU - Navarria, Federico

AU - De Paoli, Antonino

AU - Guido, Alessandra

AU - Vecchi, Claudio

AU - Basilico, Raffaella

AU - Cianci, Roberta

AU - Delli Pizzi, Andrea

AU - Di Nicola, Marta

AU - Mattiucci, Gian Carlo

AU - Valentini, Vincenzo

AU - Morganti, Alessio Giuseppe

AU - Genovesi, Domenico

PY - 2019/4

Y1 - 2019/4

N2 - BACKGROUND: Due to the high soft tissue resolution, magnetic resonance imaging (MRI) could improve the accuracy of pancreatic tumor delineation in radiation treatment planning. A multi-institutional study was proposed to evaluate the impact of MRI on inter-observer agreement in gross tumor volume (GTV) and duodenum delineation for pancreatic cancer compared with computer tomography (CT). MATERIAL AND METHODS: Two clinical cases of borderline resectable (Case 1) and unresectable (Case 2) pancreatic cancer were selected. In two sequential steps, diagnostic contrast-enhanced CT scan and MRI sequences were sent to the participating centers. CT-GTVs were contoured while blinded to MRI data sets. DICE index was used to evaluate the spatial overlap accuracy. RESULTS: Thirty-one radiation oncologists from different Institutions submitted the delineated volumes. CT- and MRI-GTV mean volumes were 21.6 ± 9.0 cm(3) and 17.2 ± 6.0 cm(3), respectively for Case 1, and 31.3 ± 15.6 cm(3) and 33.2 ± 20.2 cm(3), respectively for Case 2. Resulting MRI-GTV mean volume was significantly smaller than CT-GTV in the borderline resectable case (p

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KW - Observer Variation

KW - Pancreatic Neoplasms/diagnostic imaging/pathology

KW - Prognosis

KW - Radiotherapy Planning, Computer-Assisted

KW - Retrospective Studies

KW - Tomography, X-Ray Computed/methods

KW - Tumor Burden

U2 - 10.1080/0284186X.2018.1546899

DO - 10.1080/0284186X.2018.1546899

M3 - Article

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EP - 447

JO - Acta Oncologica

JF - Acta Oncologica

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