Abstract
Background Breast magnetic resonance imaging (MRI) is more accurate than ultrasound and mammography in estimating local extension of both invasive breast cancer and ductal carcinoma in situ (DCIS) and it is part of a breast cancer patient's preoperative management. Purpose To verify if time interval between breast biopsy and preoperative MRI, lesion margins, and biopsy technique can influence tumor sizing on MRI. Material and Methods By a database search, we retrospectively identified all women with a newly diagnosed, biopsy-proven, primary breast cancer who underwent MRI before surgery. The time interval between biopsy and MRI, the type of biopsy procedure, and various pathological features of tumors were collected. We defined the concordance between MRI and pathology measurements as a difference of <5 mm in lesion sizing. Results One hundred and sixty-six women (mean age, 51.4 ± 10.4 years) were included. The time interval between biopsy and MRI showed only a weak correlation with the absolute MRI-pathology difference (r = 0.236). Stratifying the whole cohort of patients using a cutoff value of 30 days, we found that the MRI-pathology discordance was significantly higher in patients with a biopsy-MRI time interval >30 days (P < 0.05). By means of multivariate analysis, we found that DCIS subtype and the presence of poorly defined margins on MRI are the only two factors independently and strongly associated with MRI-pathology discordance in lesion sizing. Conclusion Size, histology, and margins of tumors may affect the accuracy of MRI measurements. The type of biopsy procedure and the time interval between biopsy and preoperative MRI are not independently associated to MRI-pathology discordance.
| Original language | English |
|---|---|
| Pages (from-to) | 800-808 |
| Number of pages | 9 |
| Journal | Acta Radiologica |
| Volume | 58 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - Jul 1 2017 |
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Keywords
- breast
- core biopsy
- ductal carcinoma in situ (DCIS)
- fine needle aspiration cytology (FNAC)
- Magnetic resonance imaging (MRI)
- vacuum-assisted breast biopsy
ASJC Scopus subject areas
- Radiological and Ultrasound Technology
- Radiology Nuclear Medicine and imaging
Cite this
Magnetic resonance imaging of breast cancer : Does the time interval between biopsy and MRI influence MRI-pathology discordance in lesion sizing? / Mennella, Simone; Paparo, Francesco; Revelli, Matteo; Baccini, Paola; Secondini, Lucia; Barbagallo, Stella; Friedman, Daniele; Garlaschi, Alessandro.
In: Acta Radiologica, Vol. 58, No. 7, 01.07.2017, p. 800-808.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Magnetic resonance imaging of breast cancer
T2 - Does the time interval between biopsy and MRI influence MRI-pathology discordance in lesion sizing?
AU - Mennella, Simone
AU - Paparo, Francesco
AU - Revelli, Matteo
AU - Baccini, Paola
AU - Secondini, Lucia
AU - Barbagallo, Stella
AU - Friedman, Daniele
AU - Garlaschi, Alessandro
PY - 2017/7/1
Y1 - 2017/7/1
N2 - Background Breast magnetic resonance imaging (MRI) is more accurate than ultrasound and mammography in estimating local extension of both invasive breast cancer and ductal carcinoma in situ (DCIS) and it is part of a breast cancer patient's preoperative management. Purpose To verify if time interval between breast biopsy and preoperative MRI, lesion margins, and biopsy technique can influence tumor sizing on MRI. Material and Methods By a database search, we retrospectively identified all women with a newly diagnosed, biopsy-proven, primary breast cancer who underwent MRI before surgery. The time interval between biopsy and MRI, the type of biopsy procedure, and various pathological features of tumors were collected. We defined the concordance between MRI and pathology measurements as a difference of <5 mm in lesion sizing. Results One hundred and sixty-six women (mean age, 51.4 ± 10.4 years) were included. The time interval between biopsy and MRI showed only a weak correlation with the absolute MRI-pathology difference (r = 0.236). Stratifying the whole cohort of patients using a cutoff value of 30 days, we found that the MRI-pathology discordance was significantly higher in patients with a biopsy-MRI time interval >30 days (P < 0.05). By means of multivariate analysis, we found that DCIS subtype and the presence of poorly defined margins on MRI are the only two factors independently and strongly associated with MRI-pathology discordance in lesion sizing. Conclusion Size, histology, and margins of tumors may affect the accuracy of MRI measurements. The type of biopsy procedure and the time interval between biopsy and preoperative MRI are not independently associated to MRI-pathology discordance.
AB - Background Breast magnetic resonance imaging (MRI) is more accurate than ultrasound and mammography in estimating local extension of both invasive breast cancer and ductal carcinoma in situ (DCIS) and it is part of a breast cancer patient's preoperative management. Purpose To verify if time interval between breast biopsy and preoperative MRI, lesion margins, and biopsy technique can influence tumor sizing on MRI. Material and Methods By a database search, we retrospectively identified all women with a newly diagnosed, biopsy-proven, primary breast cancer who underwent MRI before surgery. The time interval between biopsy and MRI, the type of biopsy procedure, and various pathological features of tumors were collected. We defined the concordance between MRI and pathology measurements as a difference of <5 mm in lesion sizing. Results One hundred and sixty-six women (mean age, 51.4 ± 10.4 years) were included. The time interval between biopsy and MRI showed only a weak correlation with the absolute MRI-pathology difference (r = 0.236). Stratifying the whole cohort of patients using a cutoff value of 30 days, we found that the MRI-pathology discordance was significantly higher in patients with a biopsy-MRI time interval >30 days (P < 0.05). By means of multivariate analysis, we found that DCIS subtype and the presence of poorly defined margins on MRI are the only two factors independently and strongly associated with MRI-pathology discordance in lesion sizing. Conclusion Size, histology, and margins of tumors may affect the accuracy of MRI measurements. The type of biopsy procedure and the time interval between biopsy and preoperative MRI are not independently associated to MRI-pathology discordance.
KW - breast
KW - core biopsy
KW - ductal carcinoma in situ (DCIS)
KW - fine needle aspiration cytology (FNAC)
KW - Magnetic resonance imaging (MRI)
KW - vacuum-assisted breast biopsy
UR - http://www.scopus.com/inward/record.url?scp=85019665760&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85019665760&partnerID=8YFLogxK
U2 - 10.1177/0284185116674498
DO - 10.1177/0284185116674498
M3 - Article
AN - SCOPUS:85019665760
VL - 58
SP - 800
EP - 808
JO - Acta Radiologica
JF - Acta Radiologica
SN - 0284-1851
IS - 7
ER -