Magnetic resonance imaging of hypothalamic hamartomas causing gelastic epilepsy

A. F. Marliani, D. Tampieri, D. Melancon, R. Ethier, S. F. Berkovic, F. Andermann

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Hypothalamic hamartomas may cause a peculiar epileptic syndrome characterized by seizures of laughter and precocious puberty. Four mentally handicapped patients suffering from gelastic epilepsy were referred to our institution for investigation; three of them also presented with precocious puberty. In all four cases magnetic resonance imaging (MRI) revealed a space-occupying lesion of the hypothalamus that was considered to be a hamartoma. Biopsies were not performed. Hamartomas appear isodense in plain computed tomography scans, and they do not enhance. Such lesions display an isointense signal in T1-weighted magnetic resonance images and a hyperintense signal in proton density and T2-weighted images. MRI is the procedure of choice for detecting such lesions at the base of the brain.

Original languageEnglish
Pages (from-to)335-339
Number of pages5
JournalCanadian Association of Radiologists Journal
Volume42
Issue number5
Publication statusPublished - 1991

Fingerprint

Precocious Puberty
Hamartoma
Partial Epilepsy
Magnetic Resonance Imaging
Laughter
Mentally Disabled Persons
Hypothalamus
Protons
Seizures
Magnetic Resonance Spectroscopy
Tomography
Biopsy
Brain
Hypothalamic hamartomas

Keywords

  • computed tomography
  • epilepsy
  • hamartoma
  • hypothalamus
  • magnetic resonance imaging
  • precocious puberty

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Marliani, A. F., Tampieri, D., Melancon, D., Ethier, R., Berkovic, S. F., & Andermann, F. (1991). Magnetic resonance imaging of hypothalamic hamartomas causing gelastic epilepsy. Canadian Association of Radiologists Journal, 42(5), 335-339.

Magnetic resonance imaging of hypothalamic hamartomas causing gelastic epilepsy. / Marliani, A. F.; Tampieri, D.; Melancon, D.; Ethier, R.; Berkovic, S. F.; Andermann, F.

In: Canadian Association of Radiologists Journal, Vol. 42, No. 5, 1991, p. 335-339.

Research output: Contribution to journalArticle

Marliani, AF, Tampieri, D, Melancon, D, Ethier, R, Berkovic, SF & Andermann, F 1991, 'Magnetic resonance imaging of hypothalamic hamartomas causing gelastic epilepsy', Canadian Association of Radiologists Journal, vol. 42, no. 5, pp. 335-339.
Marliani, A. F. ; Tampieri, D. ; Melancon, D. ; Ethier, R. ; Berkovic, S. F. ; Andermann, F. / Magnetic resonance imaging of hypothalamic hamartomas causing gelastic epilepsy. In: Canadian Association of Radiologists Journal. 1991 ; Vol. 42, No. 5. pp. 335-339.
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