Magnetic resonance imaging of renal involvement in genetically studied patients with tuberous sclerosis complex

Giovanni Pompili, Salvatore Zirpoli, Chiara Sala, Nicola Flor, Rosa Maria Alfano, Angela Volpi, Diego Brancaccio, Francesco Sardanelli, Gianpaolo Cornalba

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Purpose: To evaluate renal involvement in tuberous sclerosis complex (TSC). Materials and methods: A series of 24 TSC patients (19 with genetically demonstrated disease), underwent abdominal 1.0-T MR imaging with axial/coronal T1- and T2-weighted scans, with/without fat saturation. We looked for angyomiolipomas (AMLs) and cysts in 47 kidneys of 24 patients. We evaluated the percentage of parenchymal involvement by manual contouring on the coronal scans in 39 kidneys of 20 patients. Results: We detected AMLs in 15/24 (63%) patients and in 27/47 (57%) kidneys, cysts in 14/24 (58%) and in 26/47 (55%); respectively. AMLs were found in 2/4 TSC1 and in 11/15 TSC2 patients, cysts were found in 2/4 TSC1 and in 9/15 TSC2 patients. The global renal involvement ranged from 0 to 32% (median, 18%) in TSC1 and from 0 to 100% (median, 39%) in TSC2 patients. A fair correlation (r = .464) was found between patient's age and renal involvement, a good correlation (r = 0.655) between renal involvement and creatinine clearance. Conclusion: Renal parenchyma of TSC patients can be evaluated with MR imaging. A detectable renal involvement was found in 83% of patients, higher in TSC2 than in TSC1. Renal function seems to correlate with renal involvement quantified with MR imaging.

Original languageEnglish
Pages (from-to)335-341
Number of pages7
JournalEuropean Journal of Radiology
Volume72
Issue number2
DOIs
Publication statusPublished - Nov 2009

Fingerprint

Tuberous Sclerosis
Magnetic Resonance Imaging
Kidney
Cysts
Creatinine
Fats

Keywords

  • Angiomiolipoma
  • Kidney
  • MRI
  • Tuberous sclerosis

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Magnetic resonance imaging of renal involvement in genetically studied patients with tuberous sclerosis complex. / Pompili, Giovanni; Zirpoli, Salvatore; Sala, Chiara; Flor, Nicola; Alfano, Rosa Maria; Volpi, Angela; Brancaccio, Diego; Sardanelli, Francesco; Cornalba, Gianpaolo.

In: European Journal of Radiology, Vol. 72, No. 2, 11.2009, p. 335-341.

Research output: Contribution to journalArticle

Pompili, G, Zirpoli, S, Sala, C, Flor, N, Alfano, RM, Volpi, A, Brancaccio, D, Sardanelli, F & Cornalba, G 2009, 'Magnetic resonance imaging of renal involvement in genetically studied patients with tuberous sclerosis complex', European Journal of Radiology, vol. 72, no. 2, pp. 335-341. https://doi.org/10.1016/j.ejrad.2008.07.046
Pompili, Giovanni ; Zirpoli, Salvatore ; Sala, Chiara ; Flor, Nicola ; Alfano, Rosa Maria ; Volpi, Angela ; Brancaccio, Diego ; Sardanelli, Francesco ; Cornalba, Gianpaolo. / Magnetic resonance imaging of renal involvement in genetically studied patients with tuberous sclerosis complex. In: European Journal of Radiology. 2009 ; Vol. 72, No. 2. pp. 335-341.
@article{6bbfea0d974a4601938245350e3963e3,
title = "Magnetic resonance imaging of renal involvement in genetically studied patients with tuberous sclerosis complex",
abstract = "Purpose: To evaluate renal involvement in tuberous sclerosis complex (TSC). Materials and methods: A series of 24 TSC patients (19 with genetically demonstrated disease), underwent abdominal 1.0-T MR imaging with axial/coronal T1- and T2-weighted scans, with/without fat saturation. We looked for angyomiolipomas (AMLs) and cysts in 47 kidneys of 24 patients. We evaluated the percentage of parenchymal involvement by manual contouring on the coronal scans in 39 kidneys of 20 patients. Results: We detected AMLs in 15/24 (63{\%}) patients and in 27/47 (57{\%}) kidneys, cysts in 14/24 (58{\%}) and in 26/47 (55{\%}); respectively. AMLs were found in 2/4 TSC1 and in 11/15 TSC2 patients, cysts were found in 2/4 TSC1 and in 9/15 TSC2 patients. The global renal involvement ranged from 0 to 32{\%} (median, 18{\%}) in TSC1 and from 0 to 100{\%} (median, 39{\%}) in TSC2 patients. A fair correlation (r = .464) was found between patient's age and renal involvement, a good correlation (r = 0.655) between renal involvement and creatinine clearance. Conclusion: Renal parenchyma of TSC patients can be evaluated with MR imaging. A detectable renal involvement was found in 83{\%} of patients, higher in TSC2 than in TSC1. Renal function seems to correlate with renal involvement quantified with MR imaging.",
keywords = "Angiomiolipoma, Kidney, MRI, Tuberous sclerosis",
author = "Giovanni Pompili and Salvatore Zirpoli and Chiara Sala and Nicola Flor and Alfano, {Rosa Maria} and Angela Volpi and Diego Brancaccio and Francesco Sardanelli and Gianpaolo Cornalba",
year = "2009",
month = "11",
doi = "10.1016/j.ejrad.2008.07.046",
language = "English",
volume = "72",
pages = "335--341",
journal = "European Journal of Radiology",
issn = "0720-048X",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

TY - JOUR

T1 - Magnetic resonance imaging of renal involvement in genetically studied patients with tuberous sclerosis complex

AU - Pompili, Giovanni

AU - Zirpoli, Salvatore

AU - Sala, Chiara

AU - Flor, Nicola

AU - Alfano, Rosa Maria

AU - Volpi, Angela

AU - Brancaccio, Diego

AU - Sardanelli, Francesco

AU - Cornalba, Gianpaolo

PY - 2009/11

Y1 - 2009/11

N2 - Purpose: To evaluate renal involvement in tuberous sclerosis complex (TSC). Materials and methods: A series of 24 TSC patients (19 with genetically demonstrated disease), underwent abdominal 1.0-T MR imaging with axial/coronal T1- and T2-weighted scans, with/without fat saturation. We looked for angyomiolipomas (AMLs) and cysts in 47 kidneys of 24 patients. We evaluated the percentage of parenchymal involvement by manual contouring on the coronal scans in 39 kidneys of 20 patients. Results: We detected AMLs in 15/24 (63%) patients and in 27/47 (57%) kidneys, cysts in 14/24 (58%) and in 26/47 (55%); respectively. AMLs were found in 2/4 TSC1 and in 11/15 TSC2 patients, cysts were found in 2/4 TSC1 and in 9/15 TSC2 patients. The global renal involvement ranged from 0 to 32% (median, 18%) in TSC1 and from 0 to 100% (median, 39%) in TSC2 patients. A fair correlation (r = .464) was found between patient's age and renal involvement, a good correlation (r = 0.655) between renal involvement and creatinine clearance. Conclusion: Renal parenchyma of TSC patients can be evaluated with MR imaging. A detectable renal involvement was found in 83% of patients, higher in TSC2 than in TSC1. Renal function seems to correlate with renal involvement quantified with MR imaging.

AB - Purpose: To evaluate renal involvement in tuberous sclerosis complex (TSC). Materials and methods: A series of 24 TSC patients (19 with genetically demonstrated disease), underwent abdominal 1.0-T MR imaging with axial/coronal T1- and T2-weighted scans, with/without fat saturation. We looked for angyomiolipomas (AMLs) and cysts in 47 kidneys of 24 patients. We evaluated the percentage of parenchymal involvement by manual contouring on the coronal scans in 39 kidneys of 20 patients. Results: We detected AMLs in 15/24 (63%) patients and in 27/47 (57%) kidneys, cysts in 14/24 (58%) and in 26/47 (55%); respectively. AMLs were found in 2/4 TSC1 and in 11/15 TSC2 patients, cysts were found in 2/4 TSC1 and in 9/15 TSC2 patients. The global renal involvement ranged from 0 to 32% (median, 18%) in TSC1 and from 0 to 100% (median, 39%) in TSC2 patients. A fair correlation (r = .464) was found between patient's age and renal involvement, a good correlation (r = 0.655) between renal involvement and creatinine clearance. Conclusion: Renal parenchyma of TSC patients can be evaluated with MR imaging. A detectable renal involvement was found in 83% of patients, higher in TSC2 than in TSC1. Renal function seems to correlate with renal involvement quantified with MR imaging.

KW - Angiomiolipoma

KW - Kidney

KW - MRI

KW - Tuberous sclerosis

UR - http://www.scopus.com/inward/record.url?scp=71849115615&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=71849115615&partnerID=8YFLogxK

U2 - 10.1016/j.ejrad.2008.07.046

DO - 10.1016/j.ejrad.2008.07.046

M3 - Article

VL - 72

SP - 335

EP - 341

JO - European Journal of Radiology

JF - European Journal of Radiology

SN - 0720-048X

IS - 2

ER -