Abstract
Purpose: To evaluate renal involvement in tuberous sclerosis complex (TSC). Materials and methods: A series of 24 TSC patients (19 with genetically demonstrated disease), underwent abdominal 1.0-T MR imaging with axial/coronal T1- and T2-weighted scans, with/without fat saturation. We looked for angyomiolipomas (AMLs) and cysts in 47 kidneys of 24 patients. We evaluated the percentage of parenchymal involvement by manual contouring on the coronal scans in 39 kidneys of 20 patients. Results: We detected AMLs in 15/24 (63%) patients and in 27/47 (57%) kidneys, cysts in 14/24 (58%) and in 26/47 (55%); respectively. AMLs were found in 2/4 TSC1 and in 11/15 TSC2 patients, cysts were found in 2/4 TSC1 and in 9/15 TSC2 patients. The global renal involvement ranged from 0 to 32% (median, 18%) in TSC1 and from 0 to 100% (median, 39%) in TSC2 patients. A fair correlation (r = .464) was found between patient's age and renal involvement, a good correlation (r = 0.655) between renal involvement and creatinine clearance. Conclusion: Renal parenchyma of TSC patients can be evaluated with MR imaging. A detectable renal involvement was found in 83% of patients, higher in TSC2 than in TSC1. Renal function seems to correlate with renal involvement quantified with MR imaging.
| Original language | English |
|---|---|
| Pages (from-to) | 335-341 |
| Number of pages | 7 |
| Journal | European Journal of Radiology |
| Volume | 72 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Nov 2009 |
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Keywords
- Angiomiolipoma
- Kidney
- MRI
- Tuberous sclerosis
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
Cite this
Magnetic resonance imaging of renal involvement in genetically studied patients with tuberous sclerosis complex. / Pompili, Giovanni; Zirpoli, Salvatore; Sala, Chiara; Flor, Nicola; Alfano, Rosa Maria; Volpi, Angela; Brancaccio, Diego; Sardanelli, Francesco; Cornalba, Gianpaolo.
In: European Journal of Radiology, Vol. 72, No. 2, 11.2009, p. 335-341.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Magnetic resonance imaging of renal involvement in genetically studied patients with tuberous sclerosis complex
AU - Pompili, Giovanni
AU - Zirpoli, Salvatore
AU - Sala, Chiara
AU - Flor, Nicola
AU - Alfano, Rosa Maria
AU - Volpi, Angela
AU - Brancaccio, Diego
AU - Sardanelli, Francesco
AU - Cornalba, Gianpaolo
PY - 2009/11
Y1 - 2009/11
N2 - Purpose: To evaluate renal involvement in tuberous sclerosis complex (TSC). Materials and methods: A series of 24 TSC patients (19 with genetically demonstrated disease), underwent abdominal 1.0-T MR imaging with axial/coronal T1- and T2-weighted scans, with/without fat saturation. We looked for angyomiolipomas (AMLs) and cysts in 47 kidneys of 24 patients. We evaluated the percentage of parenchymal involvement by manual contouring on the coronal scans in 39 kidneys of 20 patients. Results: We detected AMLs in 15/24 (63%) patients and in 27/47 (57%) kidneys, cysts in 14/24 (58%) and in 26/47 (55%); respectively. AMLs were found in 2/4 TSC1 and in 11/15 TSC2 patients, cysts were found in 2/4 TSC1 and in 9/15 TSC2 patients. The global renal involvement ranged from 0 to 32% (median, 18%) in TSC1 and from 0 to 100% (median, 39%) in TSC2 patients. A fair correlation (r = .464) was found between patient's age and renal involvement, a good correlation (r = 0.655) between renal involvement and creatinine clearance. Conclusion: Renal parenchyma of TSC patients can be evaluated with MR imaging. A detectable renal involvement was found in 83% of patients, higher in TSC2 than in TSC1. Renal function seems to correlate with renal involvement quantified with MR imaging.
AB - Purpose: To evaluate renal involvement in tuberous sclerosis complex (TSC). Materials and methods: A series of 24 TSC patients (19 with genetically demonstrated disease), underwent abdominal 1.0-T MR imaging with axial/coronal T1- and T2-weighted scans, with/without fat saturation. We looked for angyomiolipomas (AMLs) and cysts in 47 kidneys of 24 patients. We evaluated the percentage of parenchymal involvement by manual contouring on the coronal scans in 39 kidneys of 20 patients. Results: We detected AMLs in 15/24 (63%) patients and in 27/47 (57%) kidneys, cysts in 14/24 (58%) and in 26/47 (55%); respectively. AMLs were found in 2/4 TSC1 and in 11/15 TSC2 patients, cysts were found in 2/4 TSC1 and in 9/15 TSC2 patients. The global renal involvement ranged from 0 to 32% (median, 18%) in TSC1 and from 0 to 100% (median, 39%) in TSC2 patients. A fair correlation (r = .464) was found between patient's age and renal involvement, a good correlation (r = 0.655) between renal involvement and creatinine clearance. Conclusion: Renal parenchyma of TSC patients can be evaluated with MR imaging. A detectable renal involvement was found in 83% of patients, higher in TSC2 than in TSC1. Renal function seems to correlate with renal involvement quantified with MR imaging.
KW - Angiomiolipoma
KW - Kidney
KW - MRI
KW - Tuberous sclerosis
UR - http://www.scopus.com/inward/record.url?scp=71849115615&partnerID=8YFLogxK
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U2 - 10.1016/j.ejrad.2008.07.046
DO - 10.1016/j.ejrad.2008.07.046
M3 - Article
VL - 72
SP - 335
EP - 341
JO - European Journal of Radiology
JF - European Journal of Radiology
SN - 0720-048X
IS - 2
ER -