La risonanza magnetica delle metastasi cerebrali solitarie: definizione dei reperti più significativi delle tecniche non morfologiche

Translated title of the contribution: Magnetic resonance imaging of solitary brain metastases: Main findings of nonmorphological sequences

S. Gaudino, G. M. Di Lella, R. Russo, V. S. Lo Russo, F. Piludu, F. R. Quaglio, M. R. Gualano, C. De Waure, C. Colosimo

Research output: Contribution to journalArticle

Abstract

Purpose: This study was done to investigate the usefulness of diffusion-weighted (DWI), perfusion-weighted (PWI) and proton magnetic resonance (MR) spectroscopy imaging in characterising solitary brain metastases. Materials and methods: Fifty-nine solitary brain metastases were evaluated with conventional and nonmorphological MR imaging: DWI, PWI and MR spectroscopy. We evaluated size, signal intensity and contrast enhancement and calculated apparent diffusion coefficient (ADC), relative cerebral blood volume (rCBV), percentage of signal intensity recovery (PSR) and maximum values of N-acetylaspartate (NAA), choline (Cho), creatine (Cr), lipids (Lip), NAA/Cr and Cho/Cr. The nonmorphological parameters were compared with those from the literature for brain lesions that frequently enter the differential diagnosis with metastases. Results: Signal intensity and contrast enhancement patterns were variable. There was a wide range of ADC values: min:max 0.59×10 -3:1.88×10 -3. Compared with normal white matter, rCBV was higher in lesions (3.30±1.59) and lower in perilesional oedema (0.42±0.15). Mean and minimum PSR were 57% and 48%, respectively; lip and Cho were elevated and NAA reduced. Conclusions: Conventional MR findings of solitary metastases are heterogeneous, and some values of nonmorphological sequences are similar to those of other brain lesions. PWI seems to be the nonmorphological MR technique that may best contribute to the diagnosis of brain metastases.

Original languageItalian
Pages (from-to)1225-1241
Number of pages17
JournalRadiologia Medica
Volume117
Issue number7
DOIs
Publication statusPublished - Oct 2012

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Magnetic Resonance Imaging
Creatine
Neoplasm Metastasis
Choline
Brain
Magnetic Resonance Spectroscopy
Perfusion
Diffusion Magnetic Resonance Imaging
Lip
Edema
Differential Diagnosis
Lipids
N-acetylaspartate
Cerebral Blood Volume

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Medicine(all)

Cite this

Gaudino, S., Di Lella, G. M., Russo, R., Lo Russo, V. S., Piludu, F., Quaglio, F. R., ... Colosimo, C. (2012). La risonanza magnetica delle metastasi cerebrali solitarie: definizione dei reperti più significativi delle tecniche non morfologiche. Radiologia Medica, 117(7), 1225-1241. https://doi.org/10.1007/s11547-012-0846-2

La risonanza magnetica delle metastasi cerebrali solitarie : definizione dei reperti più significativi delle tecniche non morfologiche. / Gaudino, S.; Di Lella, G. M.; Russo, R.; Lo Russo, V. S.; Piludu, F.; Quaglio, F. R.; Gualano, M. R.; De Waure, C.; Colosimo, C.

In: Radiologia Medica, Vol. 117, No. 7, 10.2012, p. 1225-1241.

Research output: Contribution to journalArticle

Gaudino, S, Di Lella, GM, Russo, R, Lo Russo, VS, Piludu, F, Quaglio, FR, Gualano, MR, De Waure, C & Colosimo, C 2012, 'La risonanza magnetica delle metastasi cerebrali solitarie: definizione dei reperti più significativi delle tecniche non morfologiche', Radiologia Medica, vol. 117, no. 7, pp. 1225-1241. https://doi.org/10.1007/s11547-012-0846-2
Gaudino, S. ; Di Lella, G. M. ; Russo, R. ; Lo Russo, V. S. ; Piludu, F. ; Quaglio, F. R. ; Gualano, M. R. ; De Waure, C. ; Colosimo, C. / La risonanza magnetica delle metastasi cerebrali solitarie : definizione dei reperti più significativi delle tecniche non morfologiche. In: Radiologia Medica. 2012 ; Vol. 117, No. 7. pp. 1225-1241.
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abstract = "Purpose: This study was done to investigate the usefulness of diffusion-weighted (DWI), perfusion-weighted (PWI) and proton magnetic resonance (MR) spectroscopy imaging in characterising solitary brain metastases. Materials and methods: Fifty-nine solitary brain metastases were evaluated with conventional and nonmorphological MR imaging: DWI, PWI and MR spectroscopy. We evaluated size, signal intensity and contrast enhancement and calculated apparent diffusion coefficient (ADC), relative cerebral blood volume (rCBV), percentage of signal intensity recovery (PSR) and maximum values of N-acetylaspartate (NAA), choline (Cho), creatine (Cr), lipids (Lip), NAA/Cr and Cho/Cr. The nonmorphological parameters were compared with those from the literature for brain lesions that frequently enter the differential diagnosis with metastases. Results: Signal intensity and contrast enhancement patterns were variable. There was a wide range of ADC values: min:max 0.59×10 -3:1.88×10 -3. Compared with normal white matter, rCBV was higher in lesions (3.30±1.59) and lower in perilesional oedema (0.42±0.15). Mean and minimum PSR were 57{\%} and 48{\%}, respectively; lip and Cho were elevated and NAA reduced. Conclusions: Conventional MR findings of solitary metastases are heterogeneous, and some values of nonmorphological sequences are similar to those of other brain lesions. PWI seems to be the nonmorphological MR technique that may best contribute to the diagnosis of brain metastases.",
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AU - Russo, R.

AU - Lo Russo, V. S.

AU - Piludu, F.

AU - Quaglio, F. R.

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AU - De Waure, C.

AU - Colosimo, C.

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N2 - Purpose: This study was done to investigate the usefulness of diffusion-weighted (DWI), perfusion-weighted (PWI) and proton magnetic resonance (MR) spectroscopy imaging in characterising solitary brain metastases. Materials and methods: Fifty-nine solitary brain metastases were evaluated with conventional and nonmorphological MR imaging: DWI, PWI and MR spectroscopy. We evaluated size, signal intensity and contrast enhancement and calculated apparent diffusion coefficient (ADC), relative cerebral blood volume (rCBV), percentage of signal intensity recovery (PSR) and maximum values of N-acetylaspartate (NAA), choline (Cho), creatine (Cr), lipids (Lip), NAA/Cr and Cho/Cr. The nonmorphological parameters were compared with those from the literature for brain lesions that frequently enter the differential diagnosis with metastases. Results: Signal intensity and contrast enhancement patterns were variable. There was a wide range of ADC values: min:max 0.59×10 -3:1.88×10 -3. Compared with normal white matter, rCBV was higher in lesions (3.30±1.59) and lower in perilesional oedema (0.42±0.15). Mean and minimum PSR were 57% and 48%, respectively; lip and Cho were elevated and NAA reduced. Conclusions: Conventional MR findings of solitary metastases are heterogeneous, and some values of nonmorphological sequences are similar to those of other brain lesions. PWI seems to be the nonmorphological MR technique that may best contribute to the diagnosis of brain metastases.

AB - Purpose: This study was done to investigate the usefulness of diffusion-weighted (DWI), perfusion-weighted (PWI) and proton magnetic resonance (MR) spectroscopy imaging in characterising solitary brain metastases. Materials and methods: Fifty-nine solitary brain metastases were evaluated with conventional and nonmorphological MR imaging: DWI, PWI and MR spectroscopy. We evaluated size, signal intensity and contrast enhancement and calculated apparent diffusion coefficient (ADC), relative cerebral blood volume (rCBV), percentage of signal intensity recovery (PSR) and maximum values of N-acetylaspartate (NAA), choline (Cho), creatine (Cr), lipids (Lip), NAA/Cr and Cho/Cr. The nonmorphological parameters were compared with those from the literature for brain lesions that frequently enter the differential diagnosis with metastases. Results: Signal intensity and contrast enhancement patterns were variable. There was a wide range of ADC values: min:max 0.59×10 -3:1.88×10 -3. Compared with normal white matter, rCBV was higher in lesions (3.30±1.59) and lower in perilesional oedema (0.42±0.15). Mean and minimum PSR were 57% and 48%, respectively; lip and Cho were elevated and NAA reduced. Conclusions: Conventional MR findings of solitary metastases are heterogeneous, and some values of nonmorphological sequences are similar to those of other brain lesions. PWI seems to be the nonmorphological MR technique that may best contribute to the diagnosis of brain metastases.

KW - Brain neoplasms

KW - DWI

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KW - Solitary metastasis

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