Magnetic resonance imaging of spinal dysraphism

Paolo Tortori-Donati, Andrea Rossi, Roberta Biancheri, Armando Cama

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

Spinal cord development occurs through three consecutive periods. Gastrulation (weeks 2-3) is characterized by conversion of the embryonic disk from a bilaminar to a trilaminar arrangement and establishment of a notochord. Primary neurulation (weeks 3-4) produces the uppermost nine tenths of the spinal cord. Secondary neurolation and retrogressive differentiation (weeks 5-6) result in formation of the conus tip and filum terminale. Defects in these early embryonic stages produce spinal dysraphisms, which are characterized by anomalous differentiation and fusion of dorsal midline structures. Spinal dysraphisms may be categorized clinically into two subsets. In open spinal dysraphisms, the placode (non-neurulated neural tissue) is exposed to the environment. These disorders include myelomeningocele, myeloschisis, hemimyelomeningocele, and hemimyelocele, and are always associated with a Chiari II malformation. Closed spinal dysraphisms are covered by intact skin, although cutaneous stigmata usually indicate their presence. Two subsets may be identified based on whether a subcutaneous mass is present in the low back. Closed spinal dysraphisms with mass comprise lipomyeloschisis, lipomyelomeningocele, meningocele, and myelocystocele. Closed spinal dysraphisms without mass comprise complex dysraphic states (ranging from complete dorsal enteric fistula to neurenteric cysts, split cord malformations, dermal sinuses, caudal regression, and spinal segmental dysgenesis), bony spina bifida, fight filum terminale, filar and intradural lipomas, and persistent terminal ventricle. Magnetic resonance imaging is the imaging method of choice for investigation of this complex group of disorders.

Original languageEnglish
Pages (from-to)375-409
Number of pages35
JournalTopics in Magnetic Resonance Imaging
Volume12
Issue number6
DOIs
Publication statusPublished - 2001

Fingerprint

Cauda Equina
Spinal Dysraphism
Spinal Cord
Spina Bifida Occulta
Magnetic Resonance Imaging
Neurulation
Meningocele
Notochord
Christianity
Meningomyelocele
Gastrulation
Skin
Neural Tube Defects
Lipoma
Fistula
Lipomyelomeningocele

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Magnetic resonance imaging of spinal dysraphism. / Tortori-Donati, Paolo; Rossi, Andrea; Biancheri, Roberta; Cama, Armando.

In: Topics in Magnetic Resonance Imaging, Vol. 12, No. 6, 2001, p. 375-409.

Research output: Contribution to journalArticle

Tortori-Donati, Paolo ; Rossi, Andrea ; Biancheri, Roberta ; Cama, Armando. / Magnetic resonance imaging of spinal dysraphism. In: Topics in Magnetic Resonance Imaging. 2001 ; Vol. 12, No. 6. pp. 375-409.
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