Magnetic resonance measurement of blood and CSF flow rates with phase contrast - Normal values, repeatability and CO2 reactivity

Stefan K. Piechnik, Paul E. Summers, Peter Jezzard, James V. Byrne

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Background Similarity in flow pulsatility has been proposed as a basis for semi-automated segmentation of vessel lumens for MR-based flow measurement, but re-examinations of salient aspects of the methodology have not been widely reported. Methods 12 normal control subjects underwent repeated (3 Baseline+1 5%CO2) phase contrast measurements of CSF flow through the cerebral aqueduct and foramen magnum, and CBF through the 6 large cranial vessels at the level of the 1st vertebra. Average flows were calculated for regions temporally correlated (0.3≤Rthreshold≤0.95) to user defined seed points and their 3×3 neighbours. Results Arterial CBF averaged 710ml/min, with low variability (±4%/17%, intra-individual/group CV respectively) and was the only flow to respond significantly to 5%/mmHg CO2. Venous outflow was much smaller (298ml/min ±10%/ 72%), possibly due to the weak venous pulse and variable venous anatomy. Average CSF flows exceeded the classical 0.4ml/min CSF production rate and were highly variable - aqueduct: 0.6ml/min (±50%/93%), foramen magnum: -2.7ml/min (±158%/226%). Conclusions This preliminary analysis identified procedural steps that can improve the accuracy and repeatability of MR flow measurements, but the process remains user-dependent for the weakly pulsatile foramen magnum CSF and venous flows where variability remains a significant confound even to relatively large perturbations such as CO2 administration

Original languageEnglish
Title of host publicationActa Neurochirurgica, Supplementum
Pages263-270
Number of pages8
Edition102
DOIs
Publication statusPublished - 2008

Publication series

NameActa Neurochirurgica, Supplementum
Number102
ISSN (Print)00651419

Fingerprint

Foramen Magnum
Reference Values
Magnetic Resonance Spectroscopy
Cerebral Aqueduct
Anatomy
Seeds
Spine

Keywords

  • Cerebral blood flow
  • Flow measurement
  • Magnetic resonance imaging
  • Phase contrast

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

Piechnik, S. K., Summers, P. E., Jezzard, P., & Byrne, J. V. (2008). Magnetic resonance measurement of blood and CSF flow rates with phase contrast - Normal values, repeatability and CO2 reactivity. In Acta Neurochirurgica, Supplementum (102 ed., pp. 263-270). (Acta Neurochirurgica, Supplementum; No. 102). https://doi.org/10.1007/978-3-211-85578-2-50

Magnetic resonance measurement of blood and CSF flow rates with phase contrast - Normal values, repeatability and CO2 reactivity. / Piechnik, Stefan K.; Summers, Paul E.; Jezzard, Peter; Byrne, James V.

Acta Neurochirurgica, Supplementum. 102. ed. 2008. p. 263-270 (Acta Neurochirurgica, Supplementum; No. 102).

Research output: Chapter in Book/Report/Conference proceedingChapter

Piechnik, SK, Summers, PE, Jezzard, P & Byrne, JV 2008, Magnetic resonance measurement of blood and CSF flow rates with phase contrast - Normal values, repeatability and CO2 reactivity. in Acta Neurochirurgica, Supplementum. 102 edn, Acta Neurochirurgica, Supplementum, no. 102, pp. 263-270. https://doi.org/10.1007/978-3-211-85578-2-50
Piechnik SK, Summers PE, Jezzard P, Byrne JV. Magnetic resonance measurement of blood and CSF flow rates with phase contrast - Normal values, repeatability and CO2 reactivity. In Acta Neurochirurgica, Supplementum. 102 ed. 2008. p. 263-270. (Acta Neurochirurgica, Supplementum; 102). https://doi.org/10.1007/978-3-211-85578-2-50
Piechnik, Stefan K. ; Summers, Paul E. ; Jezzard, Peter ; Byrne, James V. / Magnetic resonance measurement of blood and CSF flow rates with phase contrast - Normal values, repeatability and CO2 reactivity. Acta Neurochirurgica, Supplementum. 102. ed. 2008. pp. 263-270 (Acta Neurochirurgica, Supplementum; 102).
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abstract = "Background Similarity in flow pulsatility has been proposed as a basis for semi-automated segmentation of vessel lumens for MR-based flow measurement, but re-examinations of salient aspects of the methodology have not been widely reported. Methods 12 normal control subjects underwent repeated (3 Baseline+1 5{\%}CO2) phase contrast measurements of CSF flow through the cerebral aqueduct and foramen magnum, and CBF through the 6 large cranial vessels at the level of the 1st vertebra. Average flows were calculated for regions temporally correlated (0.3≤Rthreshold≤0.95) to user defined seed points and their 3×3 neighbours. Results Arterial CBF averaged 710ml/min, with low variability (±4{\%}/17{\%}, intra-individual/group CV respectively) and was the only flow to respond significantly to 5{\%}/mmHg CO2. Venous outflow was much smaller (298ml/min ±10{\%}/ 72{\%}), possibly due to the weak venous pulse and variable venous anatomy. Average CSF flows exceeded the classical 0.4ml/min CSF production rate and were highly variable - aqueduct: 0.6ml/min (±50{\%}/93{\%}), foramen magnum: -2.7ml/min (±158{\%}/226{\%}). Conclusions This preliminary analysis identified procedural steps that can improve the accuracy and repeatability of MR flow measurements, but the process remains user-dependent for the weakly pulsatile foramen magnum CSF and venous flows where variability remains a significant confound even to relatively large perturbations such as CO2 administration",
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