TY - JOUR
T1 - Magnetic resonance spectroscopy in the evaluation of treatment efficacy in unipolar major depressive disorder
T2 - A review of the literature
AU - Caverzasi, Eduardo
AU - Pichiecchio, Anna
AU - Poloni, Guy Umberto
AU - Calligaro, Alessandro
AU - Pasin, Moreno
AU - Palesi, Fulvia
AU - Castellazzi, Gloria
AU - Pasquini, Massimo
AU - Biondi, Massimo
AU - Barale, Francesco
AU - Bastianello, Stefano
PY - 2012/1
Y1 - 2012/1
N2 - More and more neuroimaging studies are using in vivo proton magnetic resonance spectroscopy (1H-MRS) to explore correlates of response to therapy in major depressive disorder (MDD). Their aim is to further understanding of the effects of neurotransmitter changes in areas involved in MDD and the mechanisms underlying a good treatment response. We set out to summarise the literature from the past fifteen years on biochemical correlates of treatment response in MDD patients, reflected in pre- and post-therapy changes in 1H-MRS measurements. Our literature search identified fifteen articles reporting 1H-MRS studies in MDD treatment; no study used 1P-MRS. Despite the wide diversity of 1H-MRS methods applied, brain regions studied, and metabolite changes found, there emerged strong evidence of a correlation between changes in neurometabolite concentrations, in particular glutamate, N-acetylaspartate and choline, and a good treatment response to pharmacotherapy or antidepressant stimulation techniques.
AB - More and more neuroimaging studies are using in vivo proton magnetic resonance spectroscopy (1H-MRS) to explore correlates of response to therapy in major depressive disorder (MDD). Their aim is to further understanding of the effects of neurotransmitter changes in areas involved in MDD and the mechanisms underlying a good treatment response. We set out to summarise the literature from the past fifteen years on biochemical correlates of treatment response in MDD patients, reflected in pre- and post-therapy changes in 1H-MRS measurements. Our literature search identified fifteen articles reporting 1H-MRS studies in MDD treatment; no study used 1P-MRS. Despite the wide diversity of 1H-MRS methods applied, brain regions studied, and metabolite changes found, there emerged strong evidence of a correlation between changes in neurometabolite concentrations, in particular glutamate, N-acetylaspartate and choline, and a good treatment response to pharmacotherapy or antidepressant stimulation techniques.
KW - 1H-MRS
KW - ECT
KW - Major depression disorder
KW - MRI
KW - Pharmacological therapy
KW - Psychiatric disorders
KW - Spectroscopy
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M3 - Article
C2 - 22687162
AN - SCOPUS:84862607216
VL - 27
SP - 13
EP - 22
JO - Functional Neurology
JF - Functional Neurology
SN - 0393-5264
IS - 1
ER -