Magnetic resonance spectroscopy studies in migraine

P. Montagna, P. Cortelli, B. Barbiroli

Research output: Contribution to journalArticlepeer-review


We describe the method of 31phosphorous magnetic resonance spectroscopy and review the results when it is applied to the study of brain and muscle energy metabolism in migraine subjects. Brain energy metabolism appears to be abnormal in all major subtypes of migraine when measured both during and between attacks. Impaired energy metabolism is also documented in skeletal muscle. We suggest that migraine is associated with a generalized disorder of mitochondrial oxidative phosphorylation and that this may constitute a threshold for the triggering of migraine attacks.

Original languageEnglish
Pages (from-to)184-193
Number of pages10
Issue number3
Publication statusPublished - 1994

ASJC Scopus subject areas

  • Clinical Neurology


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