Magnetically Targeted Delivery of Sorafenib Through Magnetic Solid Lipid Nanoparticles Towards Treatment of Hepatocellular Carcinoma

F. Vischio; N. Depalo; R. M. Iacobazzi; M. P. Scavo; S. Villa; F. Canepa; S. Hee Lee; B. Chul Lee; E. Fanizza; I. Arduino; V. Laquintana; A. Lopalco; A. Lopedota; A. Cutrignelli; M. Striccoli; A. Agostiano; N. Denora; M. L. Curri

doi:10.1007/978-94-024-2041-8_30

Magnetically Targeted Delivery of Sorafenib Through Magnetic Solid Lipid Nanoparticles Towards Treatment of Hepatocellular Carcinoma

F. Vischio, N. Depalo, R. M. Iacobazzi, M. P. Scavo, S. Villa, F. Canepa, S. Hee Lee, B. Chul Lee, E. Fanizza, I. Arduino, V. Laquintana, A. Lopalco, A. Lopedota, A. Cutrignelli, M. Striccoli, A. Agostiano, N. Denora, M. L. Curri

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Superparamagnetic iron oxide nanoparticles (SPIONs) can be used for the delivery of the anticancer drug Sorafenib, which possesses multikinase inhibitor activity, to specific locations in the body through the application of an external magnetic field. In order to increase the biocompatible and protect the drug, solid lipid NPs (SLN) have been used to contain sorafenib and SPIONs by means of hot homogenization technique using cetyl palmitate as lipid matrix and polyethylene glycol-modified phospholipids (PEG lipids), in order to achieve a PEG-based anti-fouling coating on SLN surface.

Original language	English
Title of host publication	NATO Science for Peace and Security Series A
Subtitle of host publication	Chemistry and Biology
Publisher	Springer Science and Business Media B.V.
Pages	277-278
Number of pages	2
DOIs	https://doi.org/10.1007/978-94-024-2041-8_30
Publication status	Published - 2020

Publication series

Name	NATO Science for Peace and Security Series A: Chemistry and Biology
ISSN (Print)	1874-6489
ISSN (Electronic)	1874-6527

ASJC Scopus subject areas

Chemistry(all)
Biochemistry, Genetics and Molecular Biology (miscellaneous)
Safety, Risk, Reliability and Quality

Access to Document

10.1007/978-94-024-2041-8_30

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Vischio, F., Depalo, N., Iacobazzi, R. M., Scavo, M. P., Villa, S., Canepa, F., Lee, S. H., Lee, B. C., Fanizza, E., Arduino, I., Laquintana, V., Lopalco, A., Lopedota, A., Cutrignelli, A., Striccoli, M., Agostiano, A., Denora, N., & Curri, M. L. (2020). Magnetically Targeted Delivery of Sorafenib Through Magnetic Solid Lipid Nanoparticles Towards Treatment of Hepatocellular Carcinoma. In NATO Science for Peace and Security Series A: Chemistry and Biology (pp. 277-278). (NATO Science for Peace and Security Series A: Chemistry and Biology). Springer Science and Business Media B.V.. https://doi.org/10.1007/978-94-024-2041-8_30

Magnetically Targeted Delivery of Sorafenib Through Magnetic Solid Lipid Nanoparticles Towards Treatment of Hepatocellular Carcinoma. / Vischio, F.; Depalo, N.; Iacobazzi, R. M.; Scavo, M. P.; Villa, S.; Canepa, F.; Lee, S. Hee; Lee, B. Chul; Fanizza, E.; Arduino, I.; Laquintana, V.; Lopalco, A.; Lopedota, A.; Cutrignelli, A.; Striccoli, M.; Agostiano, A.; Denora, N.; Curri, M. L.

NATO Science for Peace and Security Series A: Chemistry and Biology. Springer Science and Business Media B.V., 2020. p. 277-278 (NATO Science for Peace and Security Series A: Chemistry and Biology).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Vischio, F, Depalo, N, Iacobazzi, RM , Scavo, MP , Villa, S, Canepa, F, Lee, SH, Lee, BC, Fanizza, E, Arduino, I, Laquintana, V, Lopalco, A, Lopedota, A, Cutrignelli, A, Striccoli, M, Agostiano, A, Denora, N & Curri, ML 2020, Magnetically Targeted Delivery of Sorafenib Through Magnetic Solid Lipid Nanoparticles Towards Treatment of Hepatocellular Carcinoma. in NATO Science for Peace and Security Series A: Chemistry and Biology. NATO Science for Peace and Security Series A: Chemistry and Biology, Springer Science and Business Media B.V., pp. 277-278. https://doi.org/10.1007/978-94-024-2041-8_30

Vischio F, Depalo N, Iacobazzi RM , Scavo MP , Villa S, Canepa F et al. Magnetically Targeted Delivery of Sorafenib Through Magnetic Solid Lipid Nanoparticles Towards Treatment of Hepatocellular Carcinoma. In NATO Science for Peace and Security Series A: Chemistry and Biology. Springer Science and Business Media B.V. 2020. p. 277-278. (NATO Science for Peace and Security Series A: Chemistry and Biology). https://doi.org/10.1007/978-94-024-2041-8_30

Vischio, F. ; Depalo, N. ; Iacobazzi, R. M. ; Scavo, M. P. ; Villa, S. ; Canepa, F. ; Lee, S. Hee ; Lee, B. Chul ; Fanizza, E. ; Arduino, I. ; Laquintana, V. ; Lopalco, A. ; Lopedota, A. ; Cutrignelli, A. ; Striccoli, M. ; Agostiano, A. ; Denora, N. ; Curri, M. L. / Magnetically Targeted Delivery of Sorafenib Through Magnetic Solid Lipid Nanoparticles Towards Treatment of Hepatocellular Carcinoma. NATO Science for Peace and Security Series A: Chemistry and Biology. Springer Science and Business Media B.V., 2020. pp. 277-278 (NATO Science for Peace and Security Series A: Chemistry and Biology).

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abstract = "Superparamagnetic iron oxide nanoparticles (SPIONs) can be used for the delivery of the anticancer drug Sorafenib, which possesses multikinase inhibitor activity, to specific locations in the body through the application of an external magnetic field. In order to increase the biocompatible and protect the drug, solid lipid NPs (SLN) have been used to contain sorafenib and SPIONs by means of hot homogenization technique using cetyl palmitate as lipid matrix and polyethylene glycol-modified phospholipids (PEG lipids), in order to achieve a PEG-based anti-fouling coating on SLN surface.",

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AU - Villa, S.

AU - Canepa, F.

AU - Lee, S. Hee

AU - Lee, B. Chul

AU - Fanizza, E.

AU - Arduino, I.

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