Magnetically Targeted Delivery of Sorafenib Through Magnetic Solid Lipid Nanoparticles Towards Treatment of Hepatocellular Carcinoma

F. Vischio, N. Depalo, R. M. Iacobazzi, M. P. Scavo, S. Villa, F. Canepa, S. Hee Lee, B. Chul Lee, E. Fanizza, I. Arduino, V. Laquintana, A. Lopalco, A. Lopedota, A. Cutrignelli, M. Striccoli, A. Agostiano, N. Denora, M. L. Curri

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Superparamagnetic iron oxide nanoparticles (SPIONs) can be used for the delivery of the anticancer drug Sorafenib, which possesses multikinase inhibitor activity, to specific locations in the body through the application of an external magnetic field. In order to increase the biocompatible and protect the drug, solid lipid NPs (SLN) have been used to contain sorafenib and SPIONs by means of hot homogenization technique using cetyl palmitate as lipid matrix and polyethylene glycol-modified phospholipids (PEG lipids), in order to achieve a PEG-based anti-fouling coating on SLN surface.

Original languageEnglish
Title of host publicationNATO Science for Peace and Security Series A
Subtitle of host publicationChemistry and Biology
PublisherSpringer Science and Business Media B.V.
Pages277-278
Number of pages2
DOIs
Publication statusPublished - 2020

Publication series

NameNATO Science for Peace and Security Series A: Chemistry and Biology
ISSN (Print)1874-6489
ISSN (Electronic)1874-6527

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology (miscellaneous)
  • Safety, Risk, Reliability and Quality

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