Magnetization Transfer

Mina Kim, Mara Cercignani

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Magnetization transfer (MT) imaging is a technique that indirectly assesses the status of hydrogen protons bounded to macromolecules such as lipid constituted of axons myelin sheet in tissues. It is especially useful for studying the integrity of white matter, which contains large amounts of myelin. Using high resolution MT measurements, therefore, it is possible to detect demyelination or degeneration of specific pathways in the spinal cord that are somatotopically organized. Assessing integrity of the spinal cord is crucial to the preservation of neurologic function. In this chapter, the basic principles of MT and its experimental implementation will be described. Furthermore, comparison of the different acquisition and data processing strategies for MT imaging in the spinal cord will be given, together with recipes for their practical details. The chapter will conclude with the future development of MT measurements including chemical exchange saturation transfer.

Original languageEnglish
Title of host publicationQuantitative MRI of the Spinal Cord
PublisherElsevier Inc.
Pages164-180
Number of pages17
ISBN (Print)9780123969736
DOIs
Publication statusPublished - Mar 2014

Fingerprint

Spinal Cord
Myelin Sheath
Demyelinating Diseases
Nervous System
Axons
Protons
Hydrogen
Lipids
White Matter

Keywords

  • Chemical exchange saturation transfer (CEST)
  • Magnetization transfer ratio (MTR)
  • MTCSF
  • Myelin
  • Two-pool model

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Kim, M., & Cercignani, M. (2014). Magnetization Transfer. In Quantitative MRI of the Spinal Cord (pp. 164-180). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-396973-6.00012-5

Magnetization Transfer. / Kim, Mina; Cercignani, Mara.

Quantitative MRI of the Spinal Cord. Elsevier Inc., 2014. p. 164-180.

Research output: Chapter in Book/Report/Conference proceedingChapter

Kim, M & Cercignani, M 2014, Magnetization Transfer. in Quantitative MRI of the Spinal Cord. Elsevier Inc., pp. 164-180. https://doi.org/10.1016/B978-0-12-396973-6.00012-5
Kim M, Cercignani M. Magnetization Transfer. In Quantitative MRI of the Spinal Cord. Elsevier Inc. 2014. p. 164-180 https://doi.org/10.1016/B978-0-12-396973-6.00012-5
Kim, Mina ; Cercignani, Mara. / Magnetization Transfer. Quantitative MRI of the Spinal Cord. Elsevier Inc., 2014. pp. 164-180
@inbook{f8d2db00b18d4f2d8b3b52719fdd9178,
title = "Magnetization Transfer",
abstract = "Magnetization transfer (MT) imaging is a technique that indirectly assesses the status of hydrogen protons bounded to macromolecules such as lipid constituted of axons myelin sheet in tissues. It is especially useful for studying the integrity of white matter, which contains large amounts of myelin. Using high resolution MT measurements, therefore, it is possible to detect demyelination or degeneration of specific pathways in the spinal cord that are somatotopically organized. Assessing integrity of the spinal cord is crucial to the preservation of neurologic function. In this chapter, the basic principles of MT and its experimental implementation will be described. Furthermore, comparison of the different acquisition and data processing strategies for MT imaging in the spinal cord will be given, together with recipes for their practical details. The chapter will conclude with the future development of MT measurements including chemical exchange saturation transfer.",
keywords = "Chemical exchange saturation transfer (CEST), Magnetization transfer ratio (MTR), MTCSF, Myelin, Two-pool model",
author = "Mina Kim and Mara Cercignani",
year = "2014",
month = "3",
doi = "10.1016/B978-0-12-396973-6.00012-5",
language = "English",
isbn = "9780123969736",
pages = "164--180",
booktitle = "Quantitative MRI of the Spinal Cord",
publisher = "Elsevier Inc.",

}

TY - CHAP

T1 - Magnetization Transfer

AU - Kim, Mina

AU - Cercignani, Mara

PY - 2014/3

Y1 - 2014/3

N2 - Magnetization transfer (MT) imaging is a technique that indirectly assesses the status of hydrogen protons bounded to macromolecules such as lipid constituted of axons myelin sheet in tissues. It is especially useful for studying the integrity of white matter, which contains large amounts of myelin. Using high resolution MT measurements, therefore, it is possible to detect demyelination or degeneration of specific pathways in the spinal cord that are somatotopically organized. Assessing integrity of the spinal cord is crucial to the preservation of neurologic function. In this chapter, the basic principles of MT and its experimental implementation will be described. Furthermore, comparison of the different acquisition and data processing strategies for MT imaging in the spinal cord will be given, together with recipes for their practical details. The chapter will conclude with the future development of MT measurements including chemical exchange saturation transfer.

AB - Magnetization transfer (MT) imaging is a technique that indirectly assesses the status of hydrogen protons bounded to macromolecules such as lipid constituted of axons myelin sheet in tissues. It is especially useful for studying the integrity of white matter, which contains large amounts of myelin. Using high resolution MT measurements, therefore, it is possible to detect demyelination or degeneration of specific pathways in the spinal cord that are somatotopically organized. Assessing integrity of the spinal cord is crucial to the preservation of neurologic function. In this chapter, the basic principles of MT and its experimental implementation will be described. Furthermore, comparison of the different acquisition and data processing strategies for MT imaging in the spinal cord will be given, together with recipes for their practical details. The chapter will conclude with the future development of MT measurements including chemical exchange saturation transfer.

KW - Chemical exchange saturation transfer (CEST)

KW - Magnetization transfer ratio (MTR)

KW - MTCSF

KW - Myelin

KW - Two-pool model

UR - http://www.scopus.com/inward/record.url?scp=84902636889&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84902636889&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-396973-6.00012-5

DO - 10.1016/B978-0-12-396973-6.00012-5

M3 - Chapter

AN - SCOPUS:84902636889

SN - 9780123969736

SP - 164

EP - 180

BT - Quantitative MRI of the Spinal Cord

PB - Elsevier Inc.

ER -