Magnetization transfer (MT) imaging is a technique that indirectly assesses the status of hydrogen protons bounded to macromolecules such as lipid constituted of axons myelin sheet in tissues. It is especially useful for studying the integrity of white matter, which contains large amounts of myelin. Using high resolution MT measurements, therefore, it is possible to detect demyelination or degeneration of specific pathways in the spinal cord that are somatotopically organized. Assessing integrity of the spinal cord is crucial to the preservation of neurologic function. In this chapter, the basic principles of MT and its experimental implementation will be described. Furthermore, comparison of the different acquisition and data processing strategies for MT imaging in the spinal cord will be given, together with recipes for their practical details. The chapter will conclude with the future development of MT measurements including chemical exchange saturation transfer.
|Title of host publication||Quantitative MRI of the Spinal Cord|
|Number of pages||17|
|Publication status||Published - Mar 2014|
- Chemical exchange saturation transfer (CEST)
- Magnetization transfer ratio (MTR)
- Two-pool model
ASJC Scopus subject areas