Magnetization transfer MRI in dementia disorders, Huntington's disease and parkinsonism

Nicola Tambasco, Pasquale Nigro, Michele Romoli, Simone Simoni, Lucilla Parnetti, Paolo Calabresi

Research output: Contribution to journalArticle

Abstract

Magnetic resonance imaging is the most used technique of neuroimaging. Using recent advances in magnetic resonance application it is possible to investigate several changes in neurodegenerative disease. Among different techniques, magnetization-transfer imaging (MTI), a magnetic resonance acquisition protocol assessing the magnetization exchange between protons bound to water and those bound to macromolecules, is able to identify microstructural brain tissue changes peculiar of neurodegenerative diseases. This review provides a report on the MTI technique and its use in the dementia disorders, Huntington's disease and parkinsonisms, comprehensive of the predictive values of MTI in the identification of early-phase disease.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalJournal of the Neurological Sciences
Volume353
Issue number1-2
DOIs
Publication statusPublished - Jun 15 2015

Fingerprint

Huntington Disease
Parkinsonian Disorders
Neurodegenerative Diseases
Dementia
Magnetic Resonance Imaging
Neuroimaging
Protons
Magnetic Resonance Spectroscopy
Water
Brain

Keywords

  • Dementia
  • Huntington's disease
  • Magnetic resonance imaging
  • Magnetization transfer
  • MRI
  • Parkinson's disease

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Medicine(all)

Cite this

Magnetization transfer MRI in dementia disorders, Huntington's disease and parkinsonism. / Tambasco, Nicola; Nigro, Pasquale; Romoli, Michele; Simoni, Simone; Parnetti, Lucilla; Calabresi, Paolo.

In: Journal of the Neurological Sciences, Vol. 353, No. 1-2, 15.06.2015, p. 1-8.

Research output: Contribution to journalArticle

Tambasco, Nicola ; Nigro, Pasquale ; Romoli, Michele ; Simoni, Simone ; Parnetti, Lucilla ; Calabresi, Paolo. / Magnetization transfer MRI in dementia disorders, Huntington's disease and parkinsonism. In: Journal of the Neurological Sciences. 2015 ; Vol. 353, No. 1-2. pp. 1-8.
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