Main nutrient patterns are associated with prospective weight change in adults from 10 European countries

Heinz Freisling, Pedro T. Pisa, Pietro Ferrari, Graham Byrnes, Aurelie Moskal, Christina C. Dahm, Anne Claire Vergnaud, Marie Christine Boutron-Ruault, Guy Fagherazzi, Claire Cadeau, Tilman Kühn, Jasmine Neamat-Allah, Brian Buijsse, Heiner Boeing, Jytte Halkjær, Anne Tjonneland, Camilla P. Hansen, J. Ramón Quirós, Noémie Travier, Esther Molina-Montes & 28 others Pilar Amiano, José M. Huerta, Aurelio Barricarte, Kay Tee Khaw, Nicholas Wareham, Tim J. Key, Dora Romaguera, Yunxia Lu, Camille M. Lassale, Androniki Naska, Philippos Orfanos, Antonia Trichopoulou, Giovanna Masala, Valeria Pala, Franco Berrino, Rosario Tumino, Fulvio Ricceri, Maria Santucci de Magistris, H. Bas Bueno-de-Mesquita, Marga C. Ocké, Emily Sonestedt, Ulrika Ericson, Mattias Johansson, Guri Skeie, Elisabete Weiderpass, Tonje Braaten, Petra H M Peeters, Nadia Slimani

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Purpose: Various food patterns have been associated with weight change in adults, but it is unknown which combinations of nutrients may account for such observations. We investigated associations between main nutrient patterns and prospective weight change in adults.Methods: This study includes 235,880 participants, 25–70 years old, recruited between 1992 and 2000 in 10 European countries. Intakes of 23 nutrients were estimated from country-specific validated dietary questionnaires using the harmonized EPIC Nutrient DataBase. Four nutrient patterns, explaining 67 % of the total variance of nutrient intakes, were previously identified from principal component analysis. Body weight was measured at recruitment and self-reported 5 years later. The relationship between nutrient patterns and annual weight change was examined separately for men and women using linear mixed models with random effect according to center controlling for confounders.Results: Mean weight gain was 460 g/year (SD 950) and 420 g/year (SD 940) for men and women, respectively. The annual differences in weight gain per one SD increase in the pattern scores were as follows: principal component (PC) 1, characterized by nutrients from plant food sources, was inversely associated with weight gain in men (−22 g/year; 95 % CI −33 to −10) and women (−18 g/year; 95 % CI −26 to −11). In contrast, PC4, characterized by protein, vitamin B2, phosphorus, and calcium, was associated with a weight gain of +41 g/year (95 % CI +2 to +80) and +88 g/year (95 % CI +36 to +140) in men and women, respectively. Associations with PC2, a pattern driven by many micro-nutrients, and with PC3, a pattern driven by vitamin D, were less consistent and/or non-significant. Conclusions: We identified two main nutrient patterns that are associated with moderate but significant long-term differences in weight gain in adults.

Original languageEnglish
JournalEuropean Journal of Nutrition
DOIs
Publication statusAccepted/In press - Aug 25 2015

Fingerprint

Weights and Measures
Food
Weight Gain
Edible Plants
Riboflavin
Principal Component Analysis
Vitamin D
Phosphorus
Linear Models
Body Weight
Databases
Calcium
Proteins

Keywords

  • Dietary patterns
  • Energy balance
  • Nutrients
  • Obesity
  • Public health
  • Weight gain

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Freisling, H., Pisa, P. T., Ferrari, P., Byrnes, G., Moskal, A., Dahm, C. C., ... Slimani, N. (Accepted/In press). Main nutrient patterns are associated with prospective weight change in adults from 10 European countries. European Journal of Nutrition. https://doi.org/10.1007/s00394-015-1023-x

Main nutrient patterns are associated with prospective weight change in adults from 10 European countries. / Freisling, Heinz; Pisa, Pedro T.; Ferrari, Pietro; Byrnes, Graham; Moskal, Aurelie; Dahm, Christina C.; Vergnaud, Anne Claire; Boutron-Ruault, Marie Christine; Fagherazzi, Guy; Cadeau, Claire; Kühn, Tilman; Neamat-Allah, Jasmine; Buijsse, Brian; Boeing, Heiner; Halkjær, Jytte; Tjonneland, Anne; Hansen, Camilla P.; Quirós, J. Ramón; Travier, Noémie; Molina-Montes, Esther; Amiano, Pilar; Huerta, José M.; Barricarte, Aurelio; Khaw, Kay Tee; Wareham, Nicholas; Key, Tim J.; Romaguera, Dora; Lu, Yunxia; Lassale, Camille M.; Naska, Androniki; Orfanos, Philippos; Trichopoulou, Antonia; Masala, Giovanna; Pala, Valeria; Berrino, Franco; Tumino, Rosario; Ricceri, Fulvio; de Magistris, Maria Santucci; Bueno-de-Mesquita, H. Bas; Ocké, Marga C.; Sonestedt, Emily; Ericson, Ulrika; Johansson, Mattias; Skeie, Guri; Weiderpass, Elisabete; Braaten, Tonje; Peeters, Petra H M; Slimani, Nadia.

In: European Journal of Nutrition, 25.08.2015.

Research output: Contribution to journalArticle

Freisling, H, Pisa, PT, Ferrari, P, Byrnes, G, Moskal, A, Dahm, CC, Vergnaud, AC, Boutron-Ruault, MC, Fagherazzi, G, Cadeau, C, Kühn, T, Neamat-Allah, J, Buijsse, B, Boeing, H, Halkjær, J, Tjonneland, A, Hansen, CP, Quirós, JR, Travier, N, Molina-Montes, E, Amiano, P, Huerta, JM, Barricarte, A, Khaw, KT, Wareham, N, Key, TJ, Romaguera, D, Lu, Y, Lassale, CM, Naska, A, Orfanos, P, Trichopoulou, A, Masala, G, Pala, V, Berrino, F, Tumino, R, Ricceri, F, de Magistris, MS, Bueno-de-Mesquita, HB, Ocké, MC, Sonestedt, E, Ericson, U, Johansson, M, Skeie, G, Weiderpass, E, Braaten, T, Peeters, PHM & Slimani, N 2015, 'Main nutrient patterns are associated with prospective weight change in adults from 10 European countries', European Journal of Nutrition. https://doi.org/10.1007/s00394-015-1023-x
Freisling, Heinz ; Pisa, Pedro T. ; Ferrari, Pietro ; Byrnes, Graham ; Moskal, Aurelie ; Dahm, Christina C. ; Vergnaud, Anne Claire ; Boutron-Ruault, Marie Christine ; Fagherazzi, Guy ; Cadeau, Claire ; Kühn, Tilman ; Neamat-Allah, Jasmine ; Buijsse, Brian ; Boeing, Heiner ; Halkjær, Jytte ; Tjonneland, Anne ; Hansen, Camilla P. ; Quirós, J. Ramón ; Travier, Noémie ; Molina-Montes, Esther ; Amiano, Pilar ; Huerta, José M. ; Barricarte, Aurelio ; Khaw, Kay Tee ; Wareham, Nicholas ; Key, Tim J. ; Romaguera, Dora ; Lu, Yunxia ; Lassale, Camille M. ; Naska, Androniki ; Orfanos, Philippos ; Trichopoulou, Antonia ; Masala, Giovanna ; Pala, Valeria ; Berrino, Franco ; Tumino, Rosario ; Ricceri, Fulvio ; de Magistris, Maria Santucci ; Bueno-de-Mesquita, H. Bas ; Ocké, Marga C. ; Sonestedt, Emily ; Ericson, Ulrika ; Johansson, Mattias ; Skeie, Guri ; Weiderpass, Elisabete ; Braaten, Tonje ; Peeters, Petra H M ; Slimani, Nadia. / Main nutrient patterns are associated with prospective weight change in adults from 10 European countries. In: European Journal of Nutrition. 2015.
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abstract = "Purpose: Various food patterns have been associated with weight change in adults, but it is unknown which combinations of nutrients may account for such observations. We investigated associations between main nutrient patterns and prospective weight change in adults.Methods: This study includes 235,880 participants, 25–70 years old, recruited between 1992 and 2000 in 10 European countries. Intakes of 23 nutrients were estimated from country-specific validated dietary questionnaires using the harmonized EPIC Nutrient DataBase. Four nutrient patterns, explaining 67 {\%} of the total variance of nutrient intakes, were previously identified from principal component analysis. Body weight was measured at recruitment and self-reported 5 years later. The relationship between nutrient patterns and annual weight change was examined separately for men and women using linear mixed models with random effect according to center controlling for confounders.Results: Mean weight gain was 460 g/year (SD 950) and 420 g/year (SD 940) for men and women, respectively. The annual differences in weight gain per one SD increase in the pattern scores were as follows: principal component (PC) 1, characterized by nutrients from plant food sources, was inversely associated with weight gain in men (−22 g/year; 95 {\%} CI −33 to −10) and women (−18 g/year; 95 {\%} CI −26 to −11). In contrast, PC4, characterized by protein, vitamin B2, phosphorus, and calcium, was associated with a weight gain of +41 g/year (95 {\%} CI +2 to +80) and +88 g/year (95 {\%} CI +36 to +140) in men and women, respectively. Associations with PC2, a pattern driven by many micro-nutrients, and with PC3, a pattern driven by vitamin D, were less consistent and/or non-significant. Conclusions: We identified two main nutrient patterns that are associated with moderate but significant long-term differences in weight gain in adults.",
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TY - JOUR

T1 - Main nutrient patterns are associated with prospective weight change in adults from 10 European countries

AU - Freisling, Heinz

AU - Pisa, Pedro T.

AU - Ferrari, Pietro

AU - Byrnes, Graham

AU - Moskal, Aurelie

AU - Dahm, Christina C.

AU - Vergnaud, Anne Claire

AU - Boutron-Ruault, Marie Christine

AU - Fagherazzi, Guy

AU - Cadeau, Claire

AU - Kühn, Tilman

AU - Neamat-Allah, Jasmine

AU - Buijsse, Brian

AU - Boeing, Heiner

AU - Halkjær, Jytte

AU - Tjonneland, Anne

AU - Hansen, Camilla P.

AU - Quirós, J. Ramón

AU - Travier, Noémie

AU - Molina-Montes, Esther

AU - Amiano, Pilar

AU - Huerta, José M.

AU - Barricarte, Aurelio

AU - Khaw, Kay Tee

AU - Wareham, Nicholas

AU - Key, Tim J.

AU - Romaguera, Dora

AU - Lu, Yunxia

AU - Lassale, Camille M.

AU - Naska, Androniki

AU - Orfanos, Philippos

AU - Trichopoulou, Antonia

AU - Masala, Giovanna

AU - Pala, Valeria

AU - Berrino, Franco

AU - Tumino, Rosario

AU - Ricceri, Fulvio

AU - de Magistris, Maria Santucci

AU - Bueno-de-Mesquita, H. Bas

AU - Ocké, Marga C.

AU - Sonestedt, Emily

AU - Ericson, Ulrika

AU - Johansson, Mattias

AU - Skeie, Guri

AU - Weiderpass, Elisabete

AU - Braaten, Tonje

AU - Peeters, Petra H M

AU - Slimani, Nadia

PY - 2015/8/25

Y1 - 2015/8/25

N2 - Purpose: Various food patterns have been associated with weight change in adults, but it is unknown which combinations of nutrients may account for such observations. We investigated associations between main nutrient patterns and prospective weight change in adults.Methods: This study includes 235,880 participants, 25–70 years old, recruited between 1992 and 2000 in 10 European countries. Intakes of 23 nutrients were estimated from country-specific validated dietary questionnaires using the harmonized EPIC Nutrient DataBase. Four nutrient patterns, explaining 67 % of the total variance of nutrient intakes, were previously identified from principal component analysis. Body weight was measured at recruitment and self-reported 5 years later. The relationship between nutrient patterns and annual weight change was examined separately for men and women using linear mixed models with random effect according to center controlling for confounders.Results: Mean weight gain was 460 g/year (SD 950) and 420 g/year (SD 940) for men and women, respectively. The annual differences in weight gain per one SD increase in the pattern scores were as follows: principal component (PC) 1, characterized by nutrients from plant food sources, was inversely associated with weight gain in men (−22 g/year; 95 % CI −33 to −10) and women (−18 g/year; 95 % CI −26 to −11). In contrast, PC4, characterized by protein, vitamin B2, phosphorus, and calcium, was associated with a weight gain of +41 g/year (95 % CI +2 to +80) and +88 g/year (95 % CI +36 to +140) in men and women, respectively. Associations with PC2, a pattern driven by many micro-nutrients, and with PC3, a pattern driven by vitamin D, were less consistent and/or non-significant. Conclusions: We identified two main nutrient patterns that are associated with moderate but significant long-term differences in weight gain in adults.

AB - Purpose: Various food patterns have been associated with weight change in adults, but it is unknown which combinations of nutrients may account for such observations. We investigated associations between main nutrient patterns and prospective weight change in adults.Methods: This study includes 235,880 participants, 25–70 years old, recruited between 1992 and 2000 in 10 European countries. Intakes of 23 nutrients were estimated from country-specific validated dietary questionnaires using the harmonized EPIC Nutrient DataBase. Four nutrient patterns, explaining 67 % of the total variance of nutrient intakes, were previously identified from principal component analysis. Body weight was measured at recruitment and self-reported 5 years later. The relationship between nutrient patterns and annual weight change was examined separately for men and women using linear mixed models with random effect according to center controlling for confounders.Results: Mean weight gain was 460 g/year (SD 950) and 420 g/year (SD 940) for men and women, respectively. The annual differences in weight gain per one SD increase in the pattern scores were as follows: principal component (PC) 1, characterized by nutrients from plant food sources, was inversely associated with weight gain in men (−22 g/year; 95 % CI −33 to −10) and women (−18 g/year; 95 % CI −26 to −11). In contrast, PC4, characterized by protein, vitamin B2, phosphorus, and calcium, was associated with a weight gain of +41 g/year (95 % CI +2 to +80) and +88 g/year (95 % CI +36 to +140) in men and women, respectively. Associations with PC2, a pattern driven by many micro-nutrients, and with PC3, a pattern driven by vitamin D, were less consistent and/or non-significant. Conclusions: We identified two main nutrient patterns that are associated with moderate but significant long-term differences in weight gain in adults.

KW - Dietary patterns

KW - Energy balance

KW - Nutrients

KW - Obesity

KW - Public health

KW - Weight gain

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JF - European Journal of Nutrition

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