Maintained benefits and improved survival of dynamic cardiomyoplasty by activity-rest stimulation: 5-Year results of the Italian trial on 'demand' dynamic cardiomyoplasty

Gianluca Rigatelli, Mario Barbiero, Giorgio Rigatelli, Roberto Riccardi, Franco Cobelli, Angelo Cotogni, Attilio Bandello, Ugo Carraro

Research output: Contribution to journalArticle

Abstract

Objective: Latissimus dorsi (LD) muscular degeneration caused by continuous electrical stimulation has been the main cause of the poor results of dynamic cardiomyoplasty (DCMP) and its exclusion from the recent international guidelines on heart failure. To avoid full transformation of the LD and to improve results, a new stimulation protocol was developed; fewer impulses per day are delivered, providing the LD wrap with daily periods of rest ('demand' stimulation), based on a heart rate cut-off. The aim of this work is to report the results at 5 years of follow-up of the Italian Trial of Demand Dynamic Cardiomyoplasty and to discuss their impact on the destiny of this type of cardiac assistance. Methods: Twelve patients with dilated myocardiopathy (M/F=11/1, mean age 58.2±5.8 years, sinus rhythm/atrial fibrillation=11/1) were submitted during the period 1993-1996 to DCMP and at different intervals to demand protocol. Clinical, echocardiographic, mechanographic and cardiac invasive assessments were scheduled before initiating the demand protocol and during the follow-up at 0, 6 and every 12 months. Results: The mean duration of follow-up was 40.2±13.8 months (range 18-64). There were no perioperative deaths. The demand stimulation protocol showed a decrease in 5 years in New York Health Association (NYHA) class (3.17±0.38-1.67±0.77, P=0.0001), an improvement of left ventricular ejection fraction (22.6±4.38-32.0±7.0, P

Original languageEnglish
Pages (from-to)81-85
Number of pages5
JournalEuropean Journal of Cardio-thoracic Surgery
Volume23
Issue number1
DOIs
Publication statusPublished - Jan 1 2003

Keywords

  • Circulatory assist
  • Dynamic cardiomyoplasty
  • Heart failure

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery

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