Maintaining standard volumes, efficacy and safety, of fecal microbiota transplantation for C. difficile infection during the COVID-19 pandemic: A prospective cohort study

Gianluca Ianiro, Stefano Bibbò, Luca Masucci, Gianluca Quaranta, Serena Porcari, Carlo Romano Settanni, Loris Riccardo Lopetuso, Massimo Fantoni, Maurizio Sanguinetti, Antonio Gasbarrini, Giovanni Cammarota

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Fecal microbiota transplantation (FMT) can be a life-saving treatment against recurrent Clostridioides difficile infection (CDI). It is therefore necessary to maintain this procedure available for these patients during the COVID-19 pandemic while keeping high efficacy and safety standards. Aims: To report outcomes of a FMT service that has adapted its operational workflow during COVID-19 pandemic to continue offering FMT to patients with CDI. Methods: All patients with CDI referred to our center for FMT during pandemic were prospectively included. Each step of the FMT working protocol was adapted with specific security measures to prevent the transmission of SARS-CoV-2. Results: Of 26 patients evaluated for FMT, 21 were treated for recurrent or refractory CDI. Eighteen patients completed the 8-week follow-up, and no one recurred after FMT. Follow-up is ongoing in 3 patients, although in all of them diarrhea disappeared after the first procedure. No serious adverse events were reported. Two patients had also COVID-19-related pneumonia, and were cured both from CDI and COVID-19. Conclusion: This is the first report to show that it is possible to maintain standard volumes, efficacy and safety of FMT for recurrent CDI during the COVID-19 pandemic, by adopting specific changes in the operational workflow.

Original languageEnglish
Pages (from-to)1390-1395
Number of pages6
JournalDigestive and Liver Disease
Volume52
Issue number12
DOIs
Publication statusPublished - Dec 2020

Keywords

  • C. difficile infection
  • Coronavirus
  • Covid-19
  • Fecal microbiota transplantation
  • SARS-CoV2

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Fingerprint Dive into the research topics of 'Maintaining standard volumes, efficacy and safety, of fecal microbiota transplantation for C. difficile infection during the COVID-19 pandemic: A prospective cohort study'. Together they form a unique fingerprint.

Cite this