Maintenance of a functional hematopoietic stem cell niche through galactocerebrosidase and other enzymes

Ilaria Visigalli, Alessandra Biffi

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Purpose of Review: The maintenance of a functional hematopoietic niche is critical for modulating the fate of hematopoietic stem cells (HSCs). Several enzymes were described as essential for guaranteeing niche functionality. This review summarizes the recent findings about the role of galactocerebrosidase and other enzymes involved in the maintenance of a functional HSC niche. Recent Findings: The essential role of enzymes actively involved in the maintenance of the bone marrow microenvironment, in bone remodeling, in regulating the sympathetic innervation of the niche, and in the production and relative balance of sphingolipids active in the niche has been recently highlighted. Enzymes involved in bone remodeling modify the cell-to-cell interaction between osteoblasts and HSCs. Heparanase, neutrophil elastase, and alpha-iduronidase affect the bioavailability of key cytokines and ligands within the extracellular matrix of the niche. Moreover, galactosyltransferase and galactocerebrosidase affect the function of the sympathetic nervous system and/or the balance of bioactive sphingolipids, thus influencing the SDF-1/CXCR4 axis and the proliferation of HSCs. SUMMARY: Here, we discuss the role of different enzymes directly or indirectly influencing the niche microenvironment, and we provide a comprehensive picture of their cooperative role, together with receptors, soluble factors, and the extracellular matrix, in maintaining a functional hematopoietic niche.

Original languageEnglish
Pages (from-to)214-219
Number of pages6
JournalCurrent Opinion in Hematology
Volume18
Issue number4
DOIs
Publication statusPublished - Jul 2011

Fingerprint

Galactosylceramidase
Stem Cell Niche
Hematopoietic Stem Cells
Maintenance
Enzymes
Sphingolipids
Bone Remodeling
Extracellular Matrix
Iduronidase
Galactosyltransferases
Leukocyte Elastase
Sympathetic Nervous System
Osteoblasts
Cell Communication
Biological Availability
Bone Marrow
Cytokines
Ligands

Keywords

  • enzymes
  • hematopoietic stem cells
  • niche

ASJC Scopus subject areas

  • Hematology

Cite this

Maintenance of a functional hematopoietic stem cell niche through galactocerebrosidase and other enzymes. / Visigalli, Ilaria; Biffi, Alessandra.

In: Current Opinion in Hematology, Vol. 18, No. 4, 07.2011, p. 214-219.

Research output: Contribution to journalArticle

@article{5c4be616305e44f283fc5077cc06340f,
title = "Maintenance of a functional hematopoietic stem cell niche through galactocerebrosidase and other enzymes",
abstract = "Purpose of Review: The maintenance of a functional hematopoietic niche is critical for modulating the fate of hematopoietic stem cells (HSCs). Several enzymes were described as essential for guaranteeing niche functionality. This review summarizes the recent findings about the role of galactocerebrosidase and other enzymes involved in the maintenance of a functional HSC niche. Recent Findings: The essential role of enzymes actively involved in the maintenance of the bone marrow microenvironment, in bone remodeling, in regulating the sympathetic innervation of the niche, and in the production and relative balance of sphingolipids active in the niche has been recently highlighted. Enzymes involved in bone remodeling modify the cell-to-cell interaction between osteoblasts and HSCs. Heparanase, neutrophil elastase, and alpha-iduronidase affect the bioavailability of key cytokines and ligands within the extracellular matrix of the niche. Moreover, galactosyltransferase and galactocerebrosidase affect the function of the sympathetic nervous system and/or the balance of bioactive sphingolipids, thus influencing the SDF-1/CXCR4 axis and the proliferation of HSCs. SUMMARY: Here, we discuss the role of different enzymes directly or indirectly influencing the niche microenvironment, and we provide a comprehensive picture of their cooperative role, together with receptors, soluble factors, and the extracellular matrix, in maintaining a functional hematopoietic niche.",
keywords = "enzymes, hematopoietic stem cells, niche",
author = "Ilaria Visigalli and Alessandra Biffi",
year = "2011",
month = "7",
doi = "10.1097/MOH.0b013e3283477979",
language = "English",
volume = "18",
pages = "214--219",
journal = "Current Opinion in Hematology",
issn = "1065-6251",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

TY - JOUR

T1 - Maintenance of a functional hematopoietic stem cell niche through galactocerebrosidase and other enzymes

AU - Visigalli, Ilaria

AU - Biffi, Alessandra

PY - 2011/7

Y1 - 2011/7

N2 - Purpose of Review: The maintenance of a functional hematopoietic niche is critical for modulating the fate of hematopoietic stem cells (HSCs). Several enzymes were described as essential for guaranteeing niche functionality. This review summarizes the recent findings about the role of galactocerebrosidase and other enzymes involved in the maintenance of a functional HSC niche. Recent Findings: The essential role of enzymes actively involved in the maintenance of the bone marrow microenvironment, in bone remodeling, in regulating the sympathetic innervation of the niche, and in the production and relative balance of sphingolipids active in the niche has been recently highlighted. Enzymes involved in bone remodeling modify the cell-to-cell interaction between osteoblasts and HSCs. Heparanase, neutrophil elastase, and alpha-iduronidase affect the bioavailability of key cytokines and ligands within the extracellular matrix of the niche. Moreover, galactosyltransferase and galactocerebrosidase affect the function of the sympathetic nervous system and/or the balance of bioactive sphingolipids, thus influencing the SDF-1/CXCR4 axis and the proliferation of HSCs. SUMMARY: Here, we discuss the role of different enzymes directly or indirectly influencing the niche microenvironment, and we provide a comprehensive picture of their cooperative role, together with receptors, soluble factors, and the extracellular matrix, in maintaining a functional hematopoietic niche.

AB - Purpose of Review: The maintenance of a functional hematopoietic niche is critical for modulating the fate of hematopoietic stem cells (HSCs). Several enzymes were described as essential for guaranteeing niche functionality. This review summarizes the recent findings about the role of galactocerebrosidase and other enzymes involved in the maintenance of a functional HSC niche. Recent Findings: The essential role of enzymes actively involved in the maintenance of the bone marrow microenvironment, in bone remodeling, in regulating the sympathetic innervation of the niche, and in the production and relative balance of sphingolipids active in the niche has been recently highlighted. Enzymes involved in bone remodeling modify the cell-to-cell interaction between osteoblasts and HSCs. Heparanase, neutrophil elastase, and alpha-iduronidase affect the bioavailability of key cytokines and ligands within the extracellular matrix of the niche. Moreover, galactosyltransferase and galactocerebrosidase affect the function of the sympathetic nervous system and/or the balance of bioactive sphingolipids, thus influencing the SDF-1/CXCR4 axis and the proliferation of HSCs. SUMMARY: Here, we discuss the role of different enzymes directly or indirectly influencing the niche microenvironment, and we provide a comprehensive picture of their cooperative role, together with receptors, soluble factors, and the extracellular matrix, in maintaining a functional hematopoietic niche.

KW - enzymes

KW - hematopoietic stem cells

KW - niche

UR - http://www.scopus.com/inward/record.url?scp=79958807236&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79958807236&partnerID=8YFLogxK

U2 - 10.1097/MOH.0b013e3283477979

DO - 10.1097/MOH.0b013e3283477979

M3 - Article

C2 - 21537167

AN - SCOPUS:79958807236

VL - 18

SP - 214

EP - 219

JO - Current Opinion in Hematology

JF - Current Opinion in Hematology

SN - 1065-6251

IS - 4

ER -