Maintenance of antiemetic effect of a metoclopramide-dexamethasone combination during subsequent cisplatin courses1

Francesco Cognetti, Paolo Carlini, Paola Pinnarò, Enzo M. Ruggeri, Claudio Caporali

Research output: Contribution to journalArticle

Abstract

In two previous consecutive studios on antiemetic combination of meloclopramide and dexamethasone was found to be very active against nausea and vomiting induced by cisplatin (DDP: 50 mg/m2) alone or in combination with oilier cytotoxic emelogenie drugs. In the present study the activity of the same antiemetic combination has been followed in 18 patients during subsequent DDP courses. Twelve out of 18 patients (67%) had a complete control of the side effect after the first course of chemotherapy. No statistically significant differences were found as regards the intensity of nausea and vomiting, the patients’ overall opinions and preference and the emesis duration. In conclusion this antiemetic combination can guarantee a high degree and long-term control of DDP-induced emesis al a dose of 50 nig nr given alone or in combination.

Original languageEnglish
Pages (from-to)292-294
Number of pages3
JournalOncology
Volume43
Issue number5
DOIs
Publication statusPublished - 1986

Keywords

  • Antiemetic treatment
  • Cisplatin
  • Metoclopramide-dexamethasone

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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