Maintenance of expression of tumor antigens in three-dimensional in vitro human tumor gel-supported histoculture

F. Guadagni, M. Roselli, R. M. Hoffman

Research output: Contribution to journalArticlepeer-review

Abstract

Tumor-specific anttgens are important in the study of tumor biology, tumor diagnosis and prognosis and possibly in tumor therapy. We demonstrate in this report that surgical specimens of colon, breast and ovarian tumors in native-state in vitro gel-supported three-dimensional in vitro histoculture maintain in vivo-like expression of the important tumor antigens TAG-72 and CEA. These results are in contrast to previously-reported studies indicating lack of expression of TAG-72 in monolayer cultures. Our knowledge and utilization of tumor-specific antigens, including the potential for therapy and predicting individual sensitivities could be enhanced in studies using in vitro three-dimensional gel-matrix histoculture for human tumors.

Original languageEnglish
Pages (from-to)543-546
Number of pages4
JournalAnticancer Research
Volume11
Issue number2
Publication statusPublished - 1991

Keywords

  • human tumor
  • three-dimensional histoculture
  • tumor antigens

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Fingerprint

Dive into the research topics of 'Maintenance of expression of tumor antigens in three-dimensional in vitro human tumor gel-supported histoculture'. Together they form a unique fingerprint.

Cite this