TY - JOUR
T1 - Maintenance therapy in epithelial ovarian cancer
T2 - From chemotherapy to targeted agents
AU - Falci, Cristina
AU - Dieci, Maria Vittoria
AU - Guarneri, Valentina
AU - Soldà, Caterina
AU - Bria, Emilio
AU - Tortora, Giampaolo
AU - Conte, Pierfranco
PY - 2014
Y1 - 2014
N2 - Over the past years, although no increase in the cure rate for advanced epithelial ovarian cancer patients has been achieved, a slow prolongation in patients survival has been observed, thanks to the introduction of effective second line or salvage therapies. Attempts to disease chronicization seem therefore of value in this setting. A major effort has been pursued to establish the role of maintenance therapies for epithelial ovarian cancer patients. Although chemotherapy does not seem to have an effective role, promising results are coming from trials investigating maintenance targeted treatments, especially with antiangiogenic agents or PARP inhibitors for selected patients. The aim of this article is to review current evidences on maintenance therapy for epithelial ovarian cancer and put the results in perspective.
AB - Over the past years, although no increase in the cure rate for advanced epithelial ovarian cancer patients has been achieved, a slow prolongation in patients survival has been observed, thanks to the introduction of effective second line or salvage therapies. Attempts to disease chronicization seem therefore of value in this setting. A major effort has been pursued to establish the role of maintenance therapies for epithelial ovarian cancer patients. Although chemotherapy does not seem to have an effective role, promising results are coming from trials investigating maintenance targeted treatments, especially with antiangiogenic agents or PARP inhibitors for selected patients. The aim of this article is to review current evidences on maintenance therapy for epithelial ovarian cancer and put the results in perspective.
KW - antiangiogenic agent
KW - epithelial ovarian cancer
KW - maintenance
UR - http://www.scopus.com/inward/record.url?scp=84906695618&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84906695618&partnerID=8YFLogxK
U2 - 10.1586/14737140.2014.922415
DO - 10.1586/14737140.2014.922415
M3 - Article
C2 - 24953376
AN - SCOPUS:84906695618
VL - 14
SP - 1041
EP - 1050
JO - Expert Review of Molecular Diagnostics
JF - Expert Review of Molecular Diagnostics
SN - 1473-7159
IS - 9
ER -