Maitotoxin and BAY-K-8644: two putative calcium channel activators with different effects on endogenous dopamine release from tuberoinfundibular neurons

Maurizio Taglialatela, Salvatore Amoroso, Takeshi Yasumoto, Gianfranco Di Renzo, Lucio Annunziato

Research output: Contribution to journalArticlepeer-review

Abstract

In the present study report on the effects of two putative calcium channel activators, maitotoxin and the dihydropyridine BAY-K-8644, on endogenous dopamine release from tubeeroinfundibular dopaminergic neurons. Maitotoxin stimulated basal dopamine release and this effect was calcium-dependent. By contrast BAY-K-8644,failed to produce any modification of basal or high potassium-induced dopamine release. These results suggest that maitotoxin, unlike BAY-K-8644, represents a suitable tool to investigate the functional role of calcium channels in central dopaminergic neurons.

Original languageEnglish
Pages (from-to)356-358
Number of pages3
JournalBrain Research
Volume381
Issue number2
DOIs
Publication statusPublished - Sep 3 1986

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

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