Major childhood infectious diseases and other determinants associated with type 1 diabetes: A case-control study

M. T. Tenconi, G. Devoti, M. Comelli, M. Pinon, A. Capocchiano, V. Calcaterra, G. Pretti, L. Bobba, A. Buratti, L. Cacciabue, P. De Cata, M. Lorena, E. Lovati, C. Mezzogori, A. Rea, M. Rebagliati, P. Romagnoli, M. Romani, B. Solerte, T. TogninA. Vailati

Research output: Contribution to journalArticle

Abstract

The objective of the study was to evaluate the association between infectious diseases and other events pertaining to childhood medical history and type 1 diabetes. A case-control study was carried out, taking as cases 159 type 1 diabetic patients (0-29 years) recorded from 1988 to 2000 within the population registry of the Pavia province (North Italy). As controls 318 non-diabetic subjects were matched by age and sex. A questionnaire was administered by standardised interviewers. Data were analysed by conditional logistic regression. Viral childhood diseases (OR 4.29; 95%CI 1.57-11.74) and bottle feeding (OR 1.83; 95%CI 1.08-3.09) were directly correlated to type 1 diabetes; an inverse correlation was found for vitamin D administration during lactation (0-14 years) (OR 0.31; 95%CI 0.11-0.86) and for history of scarlet fever in both sexes and age groups (OR 0.19; 95%CI 0.08-0.46). Most associations of the studied variables confirm already known findings. The significant inverse correlation of type 1 diabetes with scarlet fever history is a peculiar finding, the meaning of which is still obscure, although it has been recently described that streptococcal A infections are regulated by HLA class II alleles.

Original languageEnglish
Pages (from-to)14-19
Number of pages6
JournalActa Diabetologica
Volume44
Issue number1
DOIs
Publication statusPublished - Mar 2007

Fingerprint

Type 1 Diabetes Mellitus
Scarlet Fever
Communicable Diseases
Case-Control Studies
Bottle Feeding
Streptococcal Infections
Virus Diseases
Lactation
Vitamin D
Italy
Registries
Age Groups
Logistic Models
Alleles
Interviews
Population

Keywords

  • Case-control study
  • Childhood infections
  • Scarlet fever
  • Type 1 diabetes mellitus

ASJC Scopus subject areas

  • Endocrinology
  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Major childhood infectious diseases and other determinants associated with type 1 diabetes : A case-control study. / Tenconi, M. T.; Devoti, G.; Comelli, M.; Pinon, M.; Capocchiano, A.; Calcaterra, V.; Pretti, G.; Bobba, L.; Buratti, A.; Cacciabue, L.; De Cata, P.; Lorena, M.; Lovati, E.; Mezzogori, C.; Rea, A.; Rebagliati, M.; Romagnoli, P.; Romani, M.; Solerte, B.; Tognin, T.; Vailati, A.

In: Acta Diabetologica, Vol. 44, No. 1, 03.2007, p. 14-19.

Research output: Contribution to journalArticle

Tenconi, MT, Devoti, G, Comelli, M, Pinon, M, Capocchiano, A, Calcaterra, V, Pretti, G, Bobba, L, Buratti, A, Cacciabue, L, De Cata, P, Lorena, M, Lovati, E, Mezzogori, C, Rea, A, Rebagliati, M, Romagnoli, P, Romani, M, Solerte, B, Tognin, T & Vailati, A 2007, 'Major childhood infectious diseases and other determinants associated with type 1 diabetes: A case-control study', Acta Diabetologica, vol. 44, no. 1, pp. 14-19. https://doi.org/10.1007/s00592-007-0235-9
Tenconi, M. T. ; Devoti, G. ; Comelli, M. ; Pinon, M. ; Capocchiano, A. ; Calcaterra, V. ; Pretti, G. ; Bobba, L. ; Buratti, A. ; Cacciabue, L. ; De Cata, P. ; Lorena, M. ; Lovati, E. ; Mezzogori, C. ; Rea, A. ; Rebagliati, M. ; Romagnoli, P. ; Romani, M. ; Solerte, B. ; Tognin, T. ; Vailati, A. / Major childhood infectious diseases and other determinants associated with type 1 diabetes : A case-control study. In: Acta Diabetologica. 2007 ; Vol. 44, No. 1. pp. 14-19.
@article{93ea9474a8db4f4d87aa69b7e35bb844,
title = "Major childhood infectious diseases and other determinants associated with type 1 diabetes: A case-control study",
abstract = "The objective of the study was to evaluate the association between infectious diseases and other events pertaining to childhood medical history and type 1 diabetes. A case-control study was carried out, taking as cases 159 type 1 diabetic patients (0-29 years) recorded from 1988 to 2000 within the population registry of the Pavia province (North Italy). As controls 318 non-diabetic subjects were matched by age and sex. A questionnaire was administered by standardised interviewers. Data were analysed by conditional logistic regression. Viral childhood diseases (OR 4.29; 95{\%}CI 1.57-11.74) and bottle feeding (OR 1.83; 95{\%}CI 1.08-3.09) were directly correlated to type 1 diabetes; an inverse correlation was found for vitamin D administration during lactation (0-14 years) (OR 0.31; 95{\%}CI 0.11-0.86) and for history of scarlet fever in both sexes and age groups (OR 0.19; 95{\%}CI 0.08-0.46). Most associations of the studied variables confirm already known findings. The significant inverse correlation of type 1 diabetes with scarlet fever history is a peculiar finding, the meaning of which is still obscure, although it has been recently described that streptococcal A infections are regulated by HLA class II alleles.",
keywords = "Case-control study, Childhood infections, Scarlet fever, Type 1 diabetes mellitus",
author = "Tenconi, {M. T.} and G. Devoti and M. Comelli and M. Pinon and A. Capocchiano and V. Calcaterra and G. Pretti and L. Bobba and A. Buratti and L. Cacciabue and {De Cata}, P. and M. Lorena and E. Lovati and C. Mezzogori and A. Rea and M. Rebagliati and P. Romagnoli and M. Romani and B. Solerte and T. Tognin and A. Vailati",
year = "2007",
month = "3",
doi = "10.1007/s00592-007-0235-9",
language = "English",
volume = "44",
pages = "14--19",
journal = "Acta Diabetologica",
issn = "0940-5429",
publisher = "Springer-Verlag Italia s.r.l.",
number = "1",

}

TY - JOUR

T1 - Major childhood infectious diseases and other determinants associated with type 1 diabetes

T2 - A case-control study

AU - Tenconi, M. T.

AU - Devoti, G.

AU - Comelli, M.

AU - Pinon, M.

AU - Capocchiano, A.

AU - Calcaterra, V.

AU - Pretti, G.

AU - Bobba, L.

AU - Buratti, A.

AU - Cacciabue, L.

AU - De Cata, P.

AU - Lorena, M.

AU - Lovati, E.

AU - Mezzogori, C.

AU - Rea, A.

AU - Rebagliati, M.

AU - Romagnoli, P.

AU - Romani, M.

AU - Solerte, B.

AU - Tognin, T.

AU - Vailati, A.

PY - 2007/3

Y1 - 2007/3

N2 - The objective of the study was to evaluate the association between infectious diseases and other events pertaining to childhood medical history and type 1 diabetes. A case-control study was carried out, taking as cases 159 type 1 diabetic patients (0-29 years) recorded from 1988 to 2000 within the population registry of the Pavia province (North Italy). As controls 318 non-diabetic subjects were matched by age and sex. A questionnaire was administered by standardised interviewers. Data were analysed by conditional logistic regression. Viral childhood diseases (OR 4.29; 95%CI 1.57-11.74) and bottle feeding (OR 1.83; 95%CI 1.08-3.09) were directly correlated to type 1 diabetes; an inverse correlation was found for vitamin D administration during lactation (0-14 years) (OR 0.31; 95%CI 0.11-0.86) and for history of scarlet fever in both sexes and age groups (OR 0.19; 95%CI 0.08-0.46). Most associations of the studied variables confirm already known findings. The significant inverse correlation of type 1 diabetes with scarlet fever history is a peculiar finding, the meaning of which is still obscure, although it has been recently described that streptococcal A infections are regulated by HLA class II alleles.

AB - The objective of the study was to evaluate the association between infectious diseases and other events pertaining to childhood medical history and type 1 diabetes. A case-control study was carried out, taking as cases 159 type 1 diabetic patients (0-29 years) recorded from 1988 to 2000 within the population registry of the Pavia province (North Italy). As controls 318 non-diabetic subjects were matched by age and sex. A questionnaire was administered by standardised interviewers. Data were analysed by conditional logistic regression. Viral childhood diseases (OR 4.29; 95%CI 1.57-11.74) and bottle feeding (OR 1.83; 95%CI 1.08-3.09) were directly correlated to type 1 diabetes; an inverse correlation was found for vitamin D administration during lactation (0-14 years) (OR 0.31; 95%CI 0.11-0.86) and for history of scarlet fever in both sexes and age groups (OR 0.19; 95%CI 0.08-0.46). Most associations of the studied variables confirm already known findings. The significant inverse correlation of type 1 diabetes with scarlet fever history is a peculiar finding, the meaning of which is still obscure, although it has been recently described that streptococcal A infections are regulated by HLA class II alleles.

KW - Case-control study

KW - Childhood infections

KW - Scarlet fever

KW - Type 1 diabetes mellitus

UR - http://www.scopus.com/inward/record.url?scp=33947239707&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33947239707&partnerID=8YFLogxK

U2 - 10.1007/s00592-007-0235-9

DO - 10.1007/s00592-007-0235-9

M3 - Article

C2 - 17357880

AN - SCOPUS:33947239707

VL - 44

SP - 14

EP - 19

JO - Acta Diabetologica

JF - Acta Diabetologica

SN - 0940-5429

IS - 1

ER -