Major histocompatibility complex class II molecule expression on muscle cells is regulated by differentiation: Implications for the immunopathogenesis of muscle autoimmune diseases

Renato Mantegazza, Marinella Gebbia, Marina Mora, Rita Barresi, Pia Bernasconi, Fulvio Baggi, Ferdinando Cornelio

Research output: Contribution to journalArticlepeer-review

Abstract

Major histocompatibility complex (MHC) class II molecules are expressed on myoblasts after interferon-γ (IFN-γ) treatment, suggesting a muscle cell involvement in antigen presentation in inflammatory myopathies. However, they were not observed on normal or pathological myofibers. This discrepancy might be related to different responsiveness of developmentally differentiated muscle cells to IFN-γ. Myoblasts expressed class II transcripts and proteins after IFN-γ, while myotubes and innervated contracting muscle cells did not show staining for class II molecules. At all cell stages no loss of IFN-γ receptor was detected indicating-that myofiber maturation blocks their capacity to express MHC class II molecules. This suggests that completely differentiated myofibers cannot participate in class II restricted immunological reactions.

Original languageEnglish
Pages (from-to)53-60
Number of pages8
JournalJournal of Neuroimmunology
Volume68
Issue number1-2
DOIs
Publication statusPublished - Aug 1996

Keywords

  • Autoimmunity
  • Interferon-
  • Major histocompatibility complex
  • Muscle cell

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

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