Major psychoses symptomatology: Factor analysis of 2241 psychotic subjects

Alessandro Serretti, Marcella Rietschel, Enrico Lattuada, Harald Krauss, Thomas G. Schulze, Daniel J. Müller, Wolfgang Maier, Enrico Smeraldi

Research output: Contribution to journalArticle


Current nosography classifies major psychoses as separate disorders, but their symptomatological presentation during illness episodes largely overlaps and diagnoses may change during a lifetime. Few analyses of major psychoses symptomatology have been performed so far because of the large number of subjects needed to obtain stable factors. The purpose of this study was, therefore, to identify the symptomatologic structure common to major psychoses based on lifetime symptoms. Two thousand and forty-one inpatients affected by schizophrenic (n=1008), bipolar (n=563), major depressive (n=352), delusional (n=108) and psychotic not otherwise specified disorder (n=210) were rated for lifetime symptoms using the Operational Criteria Checklist for Psychotic Illness (OPCRIT) and included in a factorial analysis. Four factors were obtained, the first consisted of excitement symptoms, the second comprised psychotic features (delusions and hallucinations), the third comprised depression and the fourth disorganization. When scored by the OPCRIT checklist, major psychoses symptomatology is composed of excitement, depressive, delusion and disorganization symptoms.

Original languageEnglish
Pages (from-to)193-198
Number of pages6
JournalEuropean Archives of Psychiatry and Clinical Neuroscience
Issue number4
Publication statusPublished - 2001


  • Bipolar disorder
  • Depression
  • Factor analysis
  • Mood disorder
  • Paranoid disorder
  • Schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Neuropsychology and Physiological Psychology
  • Clinical Neurology

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    Serretti, A., Rietschel, M., Lattuada, E., Krauss, H., Schulze, T. G., Müller, D. J., Maier, W., & Smeraldi, E. (2001). Major psychoses symptomatology: Factor analysis of 2241 psychotic subjects. European Archives of Psychiatry and Clinical Neuroscience, 251(4), 193-198.