Major racial differences in coronary constrictor response between Japanese and Caucasians with recent myocardial infarction

Christian Pristipino; John F. Beltrame; Maria L. Finocchiaro; Ryuichi Hattori; Masatoshi Fujita; Rocco Mongiardo; Domenico Cianflone; Tommaso Sanna; Shigetake Sasayama; Attilio Maseri

Major racial differences in coronary constrictor response between Japanese and Caucasians with recent myocardial infarction

Christian Pristipino, John F. Beltrame, Maria L. Finocchiaro, Ryuichi Hattori, Masatoshi Fujita, Rocco Mongiardo, Domenico Cianflone, Tommaso Sanna, Shigetake Sasayama, Attilio Maseri

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

Background - Enhanced coronary vasomotion may contribute to acute coronary occlusion during the acute phase of myocardial infarction (AMI). Japanese have a higher incidence of variant angina than Caucasian patients, but racial differences in vasomotor reactivity early after AMI are controversial. Methods and Results - The same team studied 15 Japanese and 19 Caucasian patients within 14 days of AMI by acetylcholine injection into non- infarct-related (NIRA) and infarct-related (IRA) coronary arteries followed by nitroglycerin. Incidence of vasodilation, vasoconstriction, spasm, and basal tone were assessed in proximal, middle, and distal segments after each drug bolus by quantitative angiography. Japanese patients had much lower cholesterol levels than Caucasians (183±59 versus 247±53 mg/dL, P

Original language	English
Pages (from-to)	1102-1108
Number of pages	7
Journal	Circulation
Volume	101
Issue number	10
Publication status	Published - Mar 14 2000

Keywords

Acetylcholine
Myocardial infarction
Vasoconstriction
Vasodilation
Vasospasm

ASJC Scopus subject areas

Physiology
Cardiology and Cardiovascular Medicine

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Major racial differences in coronary constrictor response between Japanese and Caucasians with recent myocardial infarction. / Pristipino, Christian; Beltrame, John F.; Finocchiaro, Maria L.; Hattori, Ryuichi; Fujita, Masatoshi; Mongiardo, Rocco; Cianflone, Domenico; Sanna, Tommaso; Sasayama, Shigetake; Maseri, Attilio.

In: Circulation, Vol. 101, No. 10, 14.03.2000, p. 1102-1108.

Research output: Contribution to journal › Article › peer-review

Pristipino, Christian ; Beltrame, John F. ; Finocchiaro, Maria L. ; Hattori, Ryuichi ; Fujita, Masatoshi ; Mongiardo, Rocco ; Cianflone, Domenico ; Sanna, Tommaso ; Sasayama, Shigetake ; Maseri, Attilio. / Major racial differences in coronary constrictor response between Japanese and Caucasians with recent myocardial infarction. In: Circulation. 2000 ; Vol. 101, No. 10. pp. 1102-1108.

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title = "Major racial differences in coronary constrictor response between Japanese and Caucasians with recent myocardial infarction",

abstract = "Background - Enhanced coronary vasomotion may contribute to acute coronary occlusion during the acute phase of myocardial infarction (AMI). Japanese have a higher incidence of variant angina than Caucasian patients, but racial differences in vasomotor reactivity early after AMI are controversial. Methods and Results - The same team studied 15 Japanese and 19 Caucasian patients within 14 days of AMI by acetylcholine injection into non- infarct-related (NIRA) and infarct-related (IRA) coronary arteries followed by nitroglycerin. Incidence of vasodilation, vasoconstriction, spasm, and basal tone were assessed in proximal, middle, and distal segments after each drug bolus by quantitative angiography. Japanese patients had much lower cholesterol levels than Caucasians (183±59 versus 247±53 mg/dL, P",

keywords = "Acetylcholine, Myocardial infarction, Vasoconstriction, Vasodilation, Vasospasm",

author = "Christian Pristipino and Beltrame, {John F.} and Finocchiaro, {Maria L.} and Ryuichi Hattori and Masatoshi Fujita and Rocco Mongiardo and Domenico Cianflone and Tommaso Sanna and Shigetake Sasayama and Attilio Maseri",

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T1 - Major racial differences in coronary constrictor response between Japanese and Caucasians with recent myocardial infarction

AU - Pristipino, Christian

AU - Beltrame, John F.

AU - Finocchiaro, Maria L.

AU - Hattori, Ryuichi

AU - Fujita, Masatoshi

AU - Mongiardo, Rocco

AU - Cianflone, Domenico

AU - Sanna, Tommaso

AU - Sasayama, Shigetake

AU - Maseri, Attilio

PY - 2000/3/14

Y1 - 2000/3/14

N2 - Background - Enhanced coronary vasomotion may contribute to acute coronary occlusion during the acute phase of myocardial infarction (AMI). Japanese have a higher incidence of variant angina than Caucasian patients, but racial differences in vasomotor reactivity early after AMI are controversial. Methods and Results - The same team studied 15 Japanese and 19 Caucasian patients within 14 days of AMI by acetylcholine injection into non- infarct-related (NIRA) and infarct-related (IRA) coronary arteries followed by nitroglycerin. Incidence of vasodilation, vasoconstriction, spasm, and basal tone were assessed in proximal, middle, and distal segments after each drug bolus by quantitative angiography. Japanese patients had much lower cholesterol levels than Caucasians (183±59 versus 247±53 mg/dL, P

AB - Background - Enhanced coronary vasomotion may contribute to acute coronary occlusion during the acute phase of myocardial infarction (AMI). Japanese have a higher incidence of variant angina than Caucasian patients, but racial differences in vasomotor reactivity early after AMI are controversial. Methods and Results - The same team studied 15 Japanese and 19 Caucasian patients within 14 days of AMI by acetylcholine injection into non- infarct-related (NIRA) and infarct-related (IRA) coronary arteries followed by nitroglycerin. Incidence of vasodilation, vasoconstriction, spasm, and basal tone were assessed in proximal, middle, and distal segments after each drug bolus by quantitative angiography. Japanese patients had much lower cholesterol levels than Caucasians (183±59 versus 247±53 mg/dL, P

KW - Acetylcholine

KW - Myocardial infarction

KW - Vasoconstriction

KW - Vasodilation

KW - Vasospasm

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