TY - JOUR
T1 - Major racial differences in coronary constrictor response between Japanese and Caucasians with recent myocardial infarction
AU - Pristipino, Christian
AU - Beltrame, John F.
AU - Finocchiaro, Maria L.
AU - Hattori, Ryuichi
AU - Fujita, Masatoshi
AU - Mongiardo, Rocco
AU - Cianflone, Domenico
AU - Sanna, Tommaso
AU - Sasayama, Shigetake
AU - Maseri, Attilio
PY - 2000/3/14
Y1 - 2000/3/14
N2 - Background - Enhanced coronary vasomotion may contribute to acute coronary occlusion during the acute phase of myocardial infarction (AMI). Japanese have a higher incidence of variant angina than Caucasian patients, but racial differences in vasomotor reactivity early after AMI are controversial. Methods and Results - The same team studied 15 Japanese and 19 Caucasian patients within 14 days of AMI by acetylcholine injection into non- infarct-related (NIRA) and infarct-related (IRA) coronary arteries followed by nitroglycerin. Incidence of vasodilation, vasoconstriction, spasm, and basal tone were assessed in proximal, middle, and distal segments after each drug bolus by quantitative angiography. Japanese patients had much lower cholesterol levels than Caucasians (183±59 versus 247±53 mg/dL, P
AB - Background - Enhanced coronary vasomotion may contribute to acute coronary occlusion during the acute phase of myocardial infarction (AMI). Japanese have a higher incidence of variant angina than Caucasian patients, but racial differences in vasomotor reactivity early after AMI are controversial. Methods and Results - The same team studied 15 Japanese and 19 Caucasian patients within 14 days of AMI by acetylcholine injection into non- infarct-related (NIRA) and infarct-related (IRA) coronary arteries followed by nitroglycerin. Incidence of vasodilation, vasoconstriction, spasm, and basal tone were assessed in proximal, middle, and distal segments after each drug bolus by quantitative angiography. Japanese patients had much lower cholesterol levels than Caucasians (183±59 versus 247±53 mg/dL, P
KW - Acetylcholine
KW - Myocardial infarction
KW - Vasoconstriction
KW - Vasodilation
KW - Vasospasm
UR - http://www.scopus.com/inward/record.url?scp=0034646207&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034646207&partnerID=8YFLogxK
M3 - Article
C2 - 10715255
AN - SCOPUS:0034646207
VL - 101
SP - 1102
EP - 1108
JO - Circulation
JF - Circulation
SN - 0009-7322
IS - 10
ER -