Major racial differences in coronary constrictor response between Japanese and Caucasians with recent myocardial infarction

Christian Pristipino, John F. Beltrame, Maria L. Finocchiaro, Ryuichi Hattori, Masatoshi Fujita, Rocco Mongiardo, Domenico Cianflone, Tommaso Sanna, Shigetake Sasayama, Attilio Maseri

Research output: Contribution to journalArticlepeer-review

Abstract

Background - Enhanced coronary vasomotion may contribute to acute coronary occlusion during the acute phase of myocardial infarction (AMI). Japanese have a higher incidence of variant angina than Caucasian patients, but racial differences in vasomotor reactivity early after AMI are controversial. Methods and Results - The same team studied 15 Japanese and 19 Caucasian patients within 14 days of AMI by acetylcholine injection into non- infarct-related (NIRA) and infarct-related (IRA) coronary arteries followed by nitroglycerin. Incidence of vasodilation, vasoconstriction, spasm, and basal tone were assessed in proximal, middle, and distal segments after each drug bolus by quantitative angiography. Japanese patients had much lower cholesterol levels than Caucasians (183±59 versus 247±53 mg/dL, P

Original languageEnglish
Pages (from-to)1102-1108
Number of pages7
JournalCirculation
Volume101
Issue number10
Publication statusPublished - Mar 14 2000

Keywords

  • Acetylcholine
  • Myocardial infarction
  • Vasoconstriction
  • Vasodilation
  • Vasospasm

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Major racial differences in coronary constrictor response between Japanese and Caucasians with recent myocardial infarction'. Together they form a unique fingerprint.

Cite this