Chirurgia maggiore nel paziente anziano con neoplasia polmonare? Analisi dei fattori di rischio e risultati a distanza

Translated title of the contribution: Major surgery in lung cancer in elderly patients? Risk factors analisys and long-term results

B. Conti, P. P Brega Massone, C. Lequaglie, B. Magnani, I. Cataldo

Research output: Contribution to journalArticlepeer-review


Background. In the Oncological Thoracic Surgery Department of the Istituto Nazionale Tumori of Milan a retrospective study was performed on lung cancer patients 70 years old or more with the aim of evaluate the role of surgical treatment and to analyse long-term results. Methods. In our Institute from January 1988 to December 1993 151 lung cancer patients 70 years old or more underwent surgery for lung cancer. One hundred and twenty-six of them (83%) were males and 25 were females (17%), the average age was 73.09±2.91 years (median: 77; range: 70-82). All the subjects were completely staged preoperatively. In order to establish operability criteria, we considered some selection parameters. Patients general conditions were evaluated using Karnofsky score accepting only the ones with 70% or more for surgery, all the cases performed cardio-respiratory functional evaluation. Patients with: a) FEV1 2 2 >40 mmHg were excluded from surgery. Results. The operations performed were: 23 pneumonectomies, 6 bilobectomies, 93 lobectomies, 13 segmentectomies and 16 wedge resections. Eight cases were submitted to thoracectomy in association to pulmonary resection. Peroperative mortality was 3% and morbidity was 10%. Histological examination showed 69 adenocarcinomas, 65 squamous carcinomas, 4 large cells carcinomas, 4 typical carcinoids, 5 small cells carcinomas, 2 mucoepidermal carcinomas and 2 adenosquamous carcinomas. Eighty-six patients were classified at stage 1, 38 at stage II, 24 at stage III and 3 at stage IV (multifocal disease). The actuarial 4-years global survival predicted with Kaplan Meier method was 40%, in particular it was 75% for stage I patients. Conclusions. In case of resectable primary pulmonary neoplasm, surgery represents the first choice therapy; patient's age doesn't seem to be an absolute contraindication, but it has to be evaluated with biological and not with age criteria. Using adequate selection criteria, it's possible to obtain, in patients older than 70 years, long-term survivals that don't seem to differ from global survivals.

Translated title of the contributionMajor surgery in lung cancer in elderly patients? Risk factors analisys and long-term results
Original languageItalian
Pages (from-to)317-321
Number of pages5
JournalMinerva Chirurgica
Issue number3
Publication statusPublished - 2002

ASJC Scopus subject areas

  • Surgery


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