Making decisions through Myc

Sergio Nasi, Roberta Ciarapica, Richard Jucker, Jessica Rosati, Laura Soucek

Research output: Contribution to journalArticlepeer-review

Abstract

c-Myc is a transcriptional regulator involved in carcinogenesis through its role in growth control and cell cycle progression. Here we attempt to relate its role in stimulating the G1-S transition to the ability to affect functioning of key cell cycle regulators, and we focus on how its property of modulating transcription of a wide range of target genes could explain its capacity to affect multiple pathways leading to proliferation, apoptosis, growth, and transformation.

Original languageEnglish
Pages (from-to)153-162
Number of pages10
JournalFEBS Letters
Volume490
Issue number3
DOIs
Publication statusPublished - Feb 16 2001

Keywords

  • Cell cycle
  • Chromatin modelling
  • G1
  • Oncogene
  • Repression
  • Transcription

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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