Making decisions through Myc

Sergio Nasi, Roberta Ciarapica, Richard Jucker, Jessica Rosati, Laura Soucek

Research output: Contribution to journalArticle

101 Citations (Scopus)

Abstract

c-Myc is a transcriptional regulator involved in carcinogenesis through its role in growth control and cell cycle progression. Here we attempt to relate its role in stimulating the G1-S transition to the ability to affect functioning of key cell cycle regulators, and we focus on how its property of modulating transcription of a wide range of target genes could explain its capacity to affect multiple pathways leading to proliferation, apoptosis, growth, and transformation.

Original languageEnglish
Pages (from-to)153-162
Number of pages10
JournalFEBS Letters
Volume490
Issue number3
DOIs
Publication statusPublished - Feb 16 2001

Fingerprint

Decision Making
Decision making
Cells
Aptitude
Transcription
Growth
Cell Cycle Checkpoints
Cell Cycle
Carcinogenesis
Genes
Apoptosis

Keywords

  • Cell cycle
  • Chromatin modelling
  • G1
  • Oncogene
  • Repression
  • Transcription

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Nasi, S., Ciarapica, R., Jucker, R., Rosati, J., & Soucek, L. (2001). Making decisions through Myc. FEBS Letters, 490(3), 153-162. https://doi.org/10.1016/S0014-5793(01)02118-4

Making decisions through Myc. / Nasi, Sergio; Ciarapica, Roberta; Jucker, Richard; Rosati, Jessica; Soucek, Laura.

In: FEBS Letters, Vol. 490, No. 3, 16.02.2001, p. 153-162.

Research output: Contribution to journalArticle

Nasi, S, Ciarapica, R, Jucker, R, Rosati, J & Soucek, L 2001, 'Making decisions through Myc', FEBS Letters, vol. 490, no. 3, pp. 153-162. https://doi.org/10.1016/S0014-5793(01)02118-4
Nasi S, Ciarapica R, Jucker R, Rosati J, Soucek L. Making decisions through Myc. FEBS Letters. 2001 Feb 16;490(3):153-162. https://doi.org/10.1016/S0014-5793(01)02118-4
Nasi, Sergio ; Ciarapica, Roberta ; Jucker, Richard ; Rosati, Jessica ; Soucek, Laura. / Making decisions through Myc. In: FEBS Letters. 2001 ; Vol. 490, No. 3. pp. 153-162.
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