Malakoplakia of the pancreas with diffuse lymph-node involvement

Paolo Giovanni Nuciforo, Laura Moneghini, Paola Braidotti, Laura Castoldi, Paolo De Rai, Silvano Bosari

Research output: Contribution to journalArticlepeer-review


We report a case of malakoplakia involving the pancreas in a 74-year-old man with associated regional lymphoadenopathy. Histological examination of both pancreas and lymph nodes revealed a diffuse histiocytic infiltrate containing numerous Michaelis-Gutmann bodies. Electron microscopy supported the diagnosis of malakoplakia and showed bacterial-like structures. Differential diagnosis includes myofibroblastic inflammatory tumor and histiocytic neoplasms. Lymph-node involvement during malakoplakia is extremely rare and it has never been documented microscopically. Lymphohematogenous spread of bacteria may be the cause of the nodal involvement, which, however, does not appear to influence the clinical course of the disease.

Original languageEnglish
Pages (from-to)82-85
Number of pages4
JournalVirchows Archiv
Issue number1
Publication statusPublished - Jan 1 2003


  • Lymph nodes
  • Malakoplakia
  • Pancreas

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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