Since myocardial 99mTc-Sestamibi uptake is closely related to coronary blood flow and the tracer does not redistribute, resting perfusion defects may be observed even in viable regions supplied by vessels with severe stenosis. The incidence and the clinical significance of 99mTc-Sestamibi uptake defects at rest were investigated in 60 men with suspected coronary artery disease and no previous myocardial infarction, in a multicenter study. Of 60 patients, 12 showed normal coronary arteries and 48 significant coronary artery disease(> 50% luminal narrowing). Based on the presence or absence of tracer uptake defects at resting planar scans, the patients were divided into Group 1 (27 patients) and Group 2 (33 patients), respectively. A greater incidence of coronary artery disease (100% versus 64%, p99mTc-Sestamibi scintigraphy, which more frequently induced transient 99mTc-Sestamibi uptake defects in Group 1 than in Group 2 (85% versus 42%, p <0.001). A high incidence of resting 99mTc-Sestamibi uptake defects was observed in patients without previous myocardial infarction; this identified subset of patients with a-higher prevalence of coronary artery disease and multivessel involvement and with a greater impairment of the coronary reserve, as evidenced by a dipyridamole test.
|Number of pages||7|
|Journal||Journal of nuclear biology and medicine (Turin, Italy : 1991)|
|Publication status||Published - 1994|
- Coronary artery disease
- Viable myocardium
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging