Abstract
Since myocardial 99mTc-Sestamibi uptake is closely related to coronary blood flow and the tracer does not redistribute, resting perfusion defects may be observed even in viable regions supplied by vessels with severe stenosis. The incidence and the clinical significance of 99mTc-Sestamibi uptake defects at rest were investigated in 60 men with suspected coronary artery disease and no previous myocardial infarction, in a multicenter study. Of 60 patients, 12 showed normal coronary arteries and 48 significant coronary artery disease(> 50% luminal narrowing). Based on the presence or absence of tracer uptake defects at resting planar scans, the patients were divided into Group 1 (27 patients) and Group 2 (33 patients), respectively. A greater incidence of coronary artery disease (100% versus 64%, p99mTc-Sestamibi scintigraphy, which more frequently induced transient 99mTc-Sestamibi uptake defects in Group 1 than in Group 2 (85% versus 42%, p <0.001). A high incidence of resting 99mTc-Sestamibi uptake defects was observed in patients without previous myocardial infarction; this identified subset of patients with a-higher prevalence of coronary artery disease and multivessel involvement and with a greater impairment of the coronary reserve, as evidenced by a dipyridamole test.
| Original language | English |
|---|---|
| Pages (from-to) | 495-501 |
| Number of pages | 7 |
| Journal | Journal of nuclear biology and medicine (Turin, Italy : 1991) |
| Volume | 38 |
| Issue number | 3 |
| Publication status | Published - 1994 |
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Keywords
- Tc-Sestamibi
- Coronary artery disease
- Viable myocardium
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
Cite this
Maldistribution of regional myocardial perfusion at rest in patients with coronary artery disease and no previous myocardial infarction, evidenced by 99mTc-Sestamibi scintigraphy. / Marcassa, C.; Galli, M.; Parodi, M.; Marzullo, P.; Pirelli, S.; Inglese, E.; Giubbini, R.; Verna, E.; Santoro, G. M.; Bisi, G.; Sambuceti, G.; Temporelli, P. L.
In: Journal of nuclear biology and medicine (Turin, Italy : 1991), Vol. 38, No. 3, 1994, p. 495-501.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Maldistribution of regional myocardial perfusion at rest in patients with coronary artery disease and no previous myocardial infarction, evidenced by 99mTc-Sestamibi scintigraphy
AU - Marcassa, C.
AU - Galli, M.
AU - Parodi, M.
AU - Marzullo, P.
AU - Pirelli, S.
AU - Inglese, E.
AU - Giubbini, R.
AU - Verna, E.
AU - Santoro, G. M.
AU - Bisi, G.
AU - Sambuceti, G.
AU - Temporelli, P. L.
PY - 1994
Y1 - 1994
N2 - Since myocardial 99mTc-Sestamibi uptake is closely related to coronary blood flow and the tracer does not redistribute, resting perfusion defects may be observed even in viable regions supplied by vessels with severe stenosis. The incidence and the clinical significance of 99mTc-Sestamibi uptake defects at rest were investigated in 60 men with suspected coronary artery disease and no previous myocardial infarction, in a multicenter study. Of 60 patients, 12 showed normal coronary arteries and 48 significant coronary artery disease(> 50% luminal narrowing). Based on the presence or absence of tracer uptake defects at resting planar scans, the patients were divided into Group 1 (27 patients) and Group 2 (33 patients), respectively. A greater incidence of coronary artery disease (100% versus 64%, p99mTc-Sestamibi scintigraphy, which more frequently induced transient 99mTc-Sestamibi uptake defects in Group 1 than in Group 2 (85% versus 42%, p <0.001). A high incidence of resting 99mTc-Sestamibi uptake defects was observed in patients without previous myocardial infarction; this identified subset of patients with a-higher prevalence of coronary artery disease and multivessel involvement and with a greater impairment of the coronary reserve, as evidenced by a dipyridamole test.
AB - Since myocardial 99mTc-Sestamibi uptake is closely related to coronary blood flow and the tracer does not redistribute, resting perfusion defects may be observed even in viable regions supplied by vessels with severe stenosis. The incidence and the clinical significance of 99mTc-Sestamibi uptake defects at rest were investigated in 60 men with suspected coronary artery disease and no previous myocardial infarction, in a multicenter study. Of 60 patients, 12 showed normal coronary arteries and 48 significant coronary artery disease(> 50% luminal narrowing). Based on the presence or absence of tracer uptake defects at resting planar scans, the patients were divided into Group 1 (27 patients) and Group 2 (33 patients), respectively. A greater incidence of coronary artery disease (100% versus 64%, p99mTc-Sestamibi scintigraphy, which more frequently induced transient 99mTc-Sestamibi uptake defects in Group 1 than in Group 2 (85% versus 42%, p <0.001). A high incidence of resting 99mTc-Sestamibi uptake defects was observed in patients without previous myocardial infarction; this identified subset of patients with a-higher prevalence of coronary artery disease and multivessel involvement and with a greater impairment of the coronary reserve, as evidenced by a dipyridamole test.
KW - Tc-Sestamibi
KW - Coronary artery disease
KW - Viable myocardium
UR - http://www.scopus.com/inward/record.url?scp=0028113101&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028113101&partnerID=8YFLogxK
M3 - Article
VL - 38
SP - 495
EP - 501
JO - Journal of nuclear biology and medicine (Turin, Italy : 1991)
JF - Journal of nuclear biology and medicine (Turin, Italy : 1991)
SN - 0368-3249
IS - 3
ER -