Male breast cancer: Clinical features and multimodal treatment in a retrospective survey analysis at Italian centers

Nicla La Verde, Elena Collovà, Sara Lonardi, Daniele Generali, Anna Moretti, Francesco Atzori, Marina Cazzaniga, Chiara Saggia, Luca Tondulli, Ilaria Marcon, Anna Lisa Gentile, Rosalba Rossello, Olga Martelli, Stefania Aglione, Gabriella Farina, Michela Cinquini, Marina Garassino

Research output: Contribution to journalArticlepeer-review

Abstract

Aims and background. We report a collection of data about early breast cancer in male patients from 13 Italian institutions. Methods and study design. We obtained data from patient charts and performed statistical analysis. The primary end points were overall survival and disease-free survival. Results. A total of 205 men with invasive breast cancer was identified, with a median age of 66 years. Pathological characteristics were heterogeneous for T stage, N stage and HER2 status. Histological subtype was predominantly ductal infiltrating carcinoma. Most of them were hormone receptor positive. Mastectomy was the most common strategy. Postsurgical treatment was not standardized. Patients with large tumors were more likely to be treated with chemotherapy. Disease recurrence was associated with an ER+ and PR+ status. Conclusions. We identified a correlation between relapse and hormone receptor expression, as is the case in female breast cancer.

Original languageEnglish
Pages (from-to)596-600
Number of pages5
JournalTumori
Volume99
Issue number5
DOIs
Publication statusPublished - Sep 2013

Keywords

  • Adjuvant therapy
  • Early breast cancer
  • Male breast cancer
  • Systemic treatments

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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