Male sex is independently associated with faster disability accumulation in relapse-onset MS but not in primary progressive MS

Karen Ann Ribbons, Patrick McElduff, Cavit Boz, Maria Trojano, Guillermo Izquierdo, Pierre Duquette, Marc Girard, Francois Grand'Maison, Raymond Hupperts, Pierre Grammond, Celia Oreja-Guevara, Thor Petersen, Roberto Bergamaschi, Giorgio Giuliani, Michael Barnett, Vincent Van Pesch, Maria Pia Amato, Gerardo Iuliano, Marcela Fiol, Mark SleeFreek Verheul, Edgardo Cristiano, Ricardo Fernandez-Bolanos, Maria Laura Saladino, Maria Edite Rio, Jose Cabrera-Gomez, Helmut Butzkueven, Erik Van Munster, Leontien Den Braber-Moerland, Daniele La Spitaleri, Alessandra Lugaresi, Vahid Shaygannejad, Orla Gray, Norma Deri, Raed Alroughani, Jeannette Lechner-Scott

Research output: Contribution to journalArticle

Abstract

Background: Multiple Sclerosis is more common in women than men and females have more relapses than men. In a large international cohort we have evaluated the effect of gender on disability accumulation and disease progression to determine if male MS patients have a worse clinical outcome than females. Methods: Using the MSBase Registry, data from 15,826 MS patients from 25 countries was analysed. Changes in the severity of MS (EDSS) were compared between sexes using a repeated measures analysis in generalised linear mixed models. Kaplan-Meier analysis was used to test for sex difference in the time to reach EDSS milestones 3 and 6 and the secondary progressive MS. Results: In relapse onset MS patients (n = 14,453), males progressed significantly faster in their EDSS than females (0.133 vs 0.112 per year, P

Original languageEnglish
Article numbere0122686
JournalPLoS One
Volume10
Issue number6
DOIs
Publication statusPublished - Jun 5 2015

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relapse
Recurrence
gender
Kaplan-Meier Estimate
sclerosis
disease course
gender differences
Sex Characteristics
Multiple Sclerosis
Registries
Disease Progression
Linear Models
testing
methodology

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Ribbons, K. A., McElduff, P., Boz, C., Trojano, M., Izquierdo, G., Duquette, P., ... Lechner-Scott, J. (2015). Male sex is independently associated with faster disability accumulation in relapse-onset MS but not in primary progressive MS. PLoS One, 10(6), [e0122686]. https://doi.org/10.1371/journal.pone.0122686

Male sex is independently associated with faster disability accumulation in relapse-onset MS but not in primary progressive MS. / Ribbons, Karen Ann; McElduff, Patrick; Boz, Cavit; Trojano, Maria; Izquierdo, Guillermo; Duquette, Pierre; Girard, Marc; Grand'Maison, Francois; Hupperts, Raymond; Grammond, Pierre; Oreja-Guevara, Celia; Petersen, Thor; Bergamaschi, Roberto; Giuliani, Giorgio; Barnett, Michael; Van Pesch, Vincent; Amato, Maria Pia; Iuliano, Gerardo; Fiol, Marcela; Slee, Mark; Verheul, Freek; Cristiano, Edgardo; Fernandez-Bolanos, Ricardo; Saladino, Maria Laura; Rio, Maria Edite; Cabrera-Gomez, Jose; Butzkueven, Helmut; Van Munster, Erik; Braber-Moerland, Leontien Den; Spitaleri, Daniele La; Lugaresi, Alessandra; Shaygannejad, Vahid; Gray, Orla; Deri, Norma; Alroughani, Raed; Lechner-Scott, Jeannette.

In: PLoS One, Vol. 10, No. 6, e0122686, 05.06.2015.

Research output: Contribution to journalArticle

Ribbons, KA, McElduff, P, Boz, C, Trojano, M, Izquierdo, G, Duquette, P, Girard, M, Grand'Maison, F, Hupperts, R, Grammond, P, Oreja-Guevara, C, Petersen, T, Bergamaschi, R, Giuliani, G, Barnett, M, Van Pesch, V, Amato, MP, Iuliano, G, Fiol, M, Slee, M, Verheul, F, Cristiano, E, Fernandez-Bolanos, R, Saladino, ML, Rio, ME, Cabrera-Gomez, J, Butzkueven, H, Van Munster, E, Braber-Moerland, LD, Spitaleri, DL, Lugaresi, A, Shaygannejad, V, Gray, O, Deri, N, Alroughani, R & Lechner-Scott, J 2015, 'Male sex is independently associated with faster disability accumulation in relapse-onset MS but not in primary progressive MS', PLoS One, vol. 10, no. 6, e0122686. https://doi.org/10.1371/journal.pone.0122686
Ribbons, Karen Ann ; McElduff, Patrick ; Boz, Cavit ; Trojano, Maria ; Izquierdo, Guillermo ; Duquette, Pierre ; Girard, Marc ; Grand'Maison, Francois ; Hupperts, Raymond ; Grammond, Pierre ; Oreja-Guevara, Celia ; Petersen, Thor ; Bergamaschi, Roberto ; Giuliani, Giorgio ; Barnett, Michael ; Van Pesch, Vincent ; Amato, Maria Pia ; Iuliano, Gerardo ; Fiol, Marcela ; Slee, Mark ; Verheul, Freek ; Cristiano, Edgardo ; Fernandez-Bolanos, Ricardo ; Saladino, Maria Laura ; Rio, Maria Edite ; Cabrera-Gomez, Jose ; Butzkueven, Helmut ; Van Munster, Erik ; Braber-Moerland, Leontien Den ; Spitaleri, Daniele La ; Lugaresi, Alessandra ; Shaygannejad, Vahid ; Gray, Orla ; Deri, Norma ; Alroughani, Raed ; Lechner-Scott, Jeannette. / Male sex is independently associated with faster disability accumulation in relapse-onset MS but not in primary progressive MS. In: PLoS One. 2015 ; Vol. 10, No. 6.
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AU - Ribbons, Karen Ann

AU - McElduff, Patrick

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AU - Trojano, Maria

AU - Izquierdo, Guillermo

AU - Duquette, Pierre

AU - Girard, Marc

AU - Grand'Maison, Francois

AU - Hupperts, Raymond

AU - Grammond, Pierre

AU - Oreja-Guevara, Celia

AU - Petersen, Thor

AU - Bergamaschi, Roberto

AU - Giuliani, Giorgio

AU - Barnett, Michael

AU - Van Pesch, Vincent

AU - Amato, Maria Pia

AU - Iuliano, Gerardo

AU - Fiol, Marcela

AU - Slee, Mark

AU - Verheul, Freek

AU - Cristiano, Edgardo

AU - Fernandez-Bolanos, Ricardo

AU - Saladino, Maria Laura

AU - Rio, Maria Edite

AU - Cabrera-Gomez, Jose

AU - Butzkueven, Helmut

AU - Van Munster, Erik

AU - Braber-Moerland, Leontien Den

AU - Spitaleri, Daniele La

AU - Lugaresi, Alessandra

AU - Shaygannejad, Vahid

AU - Gray, Orla

AU - Deri, Norma

AU - Alroughani, Raed

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