Malformations of cortical development and epilepsy

Richard J. Leventer, Renzo Guerrini, William B. Dobyns

Research output: Contribution to journalArticle

108 Citations (Scopus)

Abstract

Malformations of cortical development (MCDs) are macroscopic or microscopic abnormalities of the cerebral cortex that arise as a consequence of an interruption to the normal steps of formation of the cortical plate. The human cortex develops its basic structure during the first two trimesters of pregnancy as a series of overlapping steps, beginning with proliferation and differentiation of neurons, which then migrate before finally organizing themselves in the developing cortex. Abnormalities at any of these stages, be they environmental or genetic in origin, may cause disruption of neuronal circuitry and predispose to a variety of clinical consequences, the most common of which is epileptic seizures. A large number of MCDs have now been described, each with characteristic pathological, clinical, and imaging features. The causes of many of these MCDs have been determined through the study of affected individuals, with many MCDs now established as being secondary to mutations in cortical development genes. This review will highlight the best-known of the human cortical malformations associated with epilepsy. The pathological, clinical, imaging, and etiologk features of each MCD will be summarized, with representative magnetic resonance imaging (MRI) images shown for each MCD. The malformations tuberous sclerosis, focal cortical dysplasia, hemimegalencephaly, classical lissencephaly, subcortical band heterotopia, periventricular nodular heterotopia, polymicrogyria, and schizencephaly will be presented.

Original languageEnglish
Pages (from-to)47-62
Number of pages16
JournalDialogues in Clinical Neuroscience
Volume10
Issue number1
Publication statusPublished - 2008

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Malformations of Cortical Development
Epilepsy
Cerebral Cortex
Periventricular Nodular Heterotopia
Classical Lissencephalies and Subcortical Band Heterotopias
Tuberous Sclerosis
First Pregnancy Trimester
Magnetic Resonance Imaging
Neurons
Mutation

Keywords

  • Band heterotopia
  • Cortical dysplasia
  • Hemimegalencephaly
  • Lissencephaly
  • Nodular heterotopia
  • Polymicrogyria
  • Schizencephaly
  • Tuberous sclerosis

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)

Cite this

Malformations of cortical development and epilepsy. / Leventer, Richard J.; Guerrini, Renzo; Dobyns, William B.

In: Dialogues in Clinical Neuroscience, Vol. 10, No. 1, 2008, p. 47-62.

Research output: Contribution to journalArticle

Leventer, Richard J. ; Guerrini, Renzo ; Dobyns, William B. / Malformations of cortical development and epilepsy. In: Dialogues in Clinical Neuroscience. 2008 ; Vol. 10, No. 1. pp. 47-62.
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