Malignancies in children with human immunodeficiency virus type 1 infection

M. Arico, D. Caselli, P. D'Argenio, A. R. Del Mistro, M. DeMartino, S. Livadiotti, N. Santoro, A. Terragna

Research output: Contribution to journalArticlepeer-review


Cancer has been closely associated with human immunodeficiency virus (HIV) infection but this is less frequent in children. Non-Hodgkin's lymphomas represent the most frequently reported single tumor. The authors report seven cases of malignant tumors resulting from the analysis of all (n = 1321) children enrolled in the Italian Register for HIV Infection in Children. Tumors were distributed as follows: non-Hodgkin's B-cell lymphoma (four cases); and Kaposi's sarcoma, hepatoblastoma, acute B-cell lymphoblastic leukemia (one case each). Hepatoblastoma had never been previously reported in HIV-infected children. Also in the current series, non-Hodgkin's B-cell lymphoma is the most frequent single tumor. Five of the seven cancers belonged to the B-cell line. All but one of the seven children have died. Specific chemotherapy was provided in three cases, with some clinical improvement. The treatment of malignancies in HIV-infected children is hampered by increased risk of opportunistic infections often fatal even in children with apparent remission from the tumor.

Original languageEnglish
Pages (from-to)2473-2477
Number of pages5
Issue number11
Publication statusPublished - 1991

ASJC Scopus subject areas

  • Cancer Research
  • Oncology


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