Malignancies in Italian patients with systemic sclerosis positive for anti-RNA polymerase III antibodies

Paolo Airo', Angela Ceribelli, Ilaria Cavazzana, Mara Taraborelli, Stefania Zingarelli, Franco Franceschini

Research output: Contribution to journalArticlepeer-review

Abstract

Objective. To evaluate the frequency of malignancies in Italian patients with systemic sclerosis (SSc) and anti-RNA polymerase III (RNAP III), antitopoisomerase I (topo I), or anticentromere antibodies (ACA); and to characterize the temporal relationship between the 2 diseases, in order to confirm data suggesting a close temporal relationship between the onset of SSc and malignancy in American patients with anti-RNAP III antibodies. Methods. From a cohort of 466 consecutive SSc patients, 360 Italians with isolated positivity for anti-RNAP III (n = 16), anti-topo I (n = 101), or ACA (n = 243) were identified. Malignancy cases were divided according to their relationship with SSc onset into 3 categories: preceding, synchronous with, or metachronous to the onset of SSc (diagnosed more than 6 months before; 6 months before to 12 months after; and more than 12 months after onset of SSc, respectively). Results. Malignancies were more frequent in the anti-RNAP III group (7/16 patients), than in the anti-topo I (11/101) and ACA groups (21/243) (p <0.001). This difference was accounted for by the number of patients with cancer synchronous to the onset of SSc (3/16 in the anti-RNAP III group vs 0/101 in the anti-topo I and 1/243 in the ACA group; p <0.001), whereas neither the number of malignancies preceding nor those metachronous to the onset of SSc was significantly different between the groups. Conclusion. In a cohort of Italian patients with SSc we observed a significant association between malignancies synchronous to SSc onset and positivity for anti-RNAP III antibodies, similar to that described in American patients with SSc. The Journal of Rheumatology

Original languageEnglish
Pages (from-to)1329-1334
Number of pages6
JournalJournal of Rheumatology
Volume38
Issue number7
DOIs
Publication statusPublished - Jul 2011

Keywords

  • Anti-RNA polymerase III antibodies
  • Anticentromere antibodies
  • Antitopoisomerase I antibodies
  • Malignancy
  • Systemic sclerosis

ASJC Scopus subject areas

  • Rheumatology
  • Immunology
  • Immunology and Allergy

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