Malignancy and sensory neuropathy of unexplained cause: A prospective study of 51 patients

Massimo Camerlingo, Raffaello Nemni, Bruno Ferraro, Luciano Casto, Tania Partziguian, Bruno Censori, Angela Mamoli

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Objective: To investigate the frequency of cancer developing in patients with peripheral sensory neuropathy of unexplained cause. Design: Prospective study. Setting: A neurologic unit in a general hospital. Methods: Following the diagnosis of neuropathy, we searched for occult malignancy. This search was repeated together with neurologic evaluations every 6 months thereafter. Patient recruitment began January 1, 1988, and ended December 31, 1995. The end point of the study was December 31, l996. Results: In the study period, we observed 363 patients with peripheral sensory neuropathy. Of these, 53 patients without any identified cause of neuropathy were invited to participate in the study. Of the 53, 2 patients refused. Thus, we examined and followed up 51 patients, 42 men and 9 women, with a mean age of 64.5 years (range, 19-80 years). The range between the onset of neurologic symptoms and the diagnosis of neuropathy was 2 to 72 months (mean, 13.9 months). The follow-up period ranged from 14 to 94 months (mean, 51.4 months). In 18 patients (35.3%) (16 men and 2 women) whose mean age at diagnosis of neuropathy was 66.5 years, malignant growths were found 3 to 72 months (mean, 27.4 months) after the onset of the neuropathy. The cancer was in the liver in 4 patients (all had a primary hepatoma), the bladder in 3, the lymph nodes in 3 (all with non-Hodgkin lymphoma), the prostate gland in 2, the lungs in 2 (small cell lung cancer in both), the breast in 1, the pancreas in 1, the sublingual gland in 1, and the bone in 1 (a metastatic sarcoma). Conclusions: More than one third of the patients with peripheral sensory neuropathy of unexplained cause developed cancer without any predominating type of malignancy.

Original languageEnglish
Pages (from-to)981-984
Number of pages4
JournalArchives of Neurology
Volume55
Issue number7
DOIs
Publication statusPublished - Jul 1998

Fingerprint

Prospective Studies
Neoplasms
Peripheral Nervous System Diseases
Nervous System
Sublingual Gland
Causes
Small Cell Lung Carcinoma
Neurologic Manifestations
General Hospitals
Sarcoma
Non-Hodgkin's Lymphoma
Patient Selection
Prostate
Pancreas
Hepatocellular Carcinoma
Urinary Bladder
Breast
Lymph Nodes
Bone and Bones
Lung

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Camerlingo, M., Nemni, R., Ferraro, B., Casto, L., Partziguian, T., Censori, B., & Mamoli, A. (1998). Malignancy and sensory neuropathy of unexplained cause: A prospective study of 51 patients. Archives of Neurology, 55(7), 981-984. https://doi.org/10.1001/archneur.55.7.981

Malignancy and sensory neuropathy of unexplained cause : A prospective study of 51 patients. / Camerlingo, Massimo; Nemni, Raffaello; Ferraro, Bruno; Casto, Luciano; Partziguian, Tania; Censori, Bruno; Mamoli, Angela.

In: Archives of Neurology, Vol. 55, No. 7, 07.1998, p. 981-984.

Research output: Contribution to journalArticle

Camerlingo, M, Nemni, R, Ferraro, B, Casto, L, Partziguian, T, Censori, B & Mamoli, A 1998, 'Malignancy and sensory neuropathy of unexplained cause: A prospective study of 51 patients', Archives of Neurology, vol. 55, no. 7, pp. 981-984. https://doi.org/10.1001/archneur.55.7.981
Camerlingo, Massimo ; Nemni, Raffaello ; Ferraro, Bruno ; Casto, Luciano ; Partziguian, Tania ; Censori, Bruno ; Mamoli, Angela. / Malignancy and sensory neuropathy of unexplained cause : A prospective study of 51 patients. In: Archives of Neurology. 1998 ; Vol. 55, No. 7. pp. 981-984.
@article{1b73c8d7777f481ca747e14accf222ae,
title = "Malignancy and sensory neuropathy of unexplained cause: A prospective study of 51 patients",
abstract = "Objective: To investigate the frequency of cancer developing in patients with peripheral sensory neuropathy of unexplained cause. Design: Prospective study. Setting: A neurologic unit in a general hospital. Methods: Following the diagnosis of neuropathy, we searched for occult malignancy. This search was repeated together with neurologic evaluations every 6 months thereafter. Patient recruitment began January 1, 1988, and ended December 31, 1995. The end point of the study was December 31, l996. Results: In the study period, we observed 363 patients with peripheral sensory neuropathy. Of these, 53 patients without any identified cause of neuropathy were invited to participate in the study. Of the 53, 2 patients refused. Thus, we examined and followed up 51 patients, 42 men and 9 women, with a mean age of 64.5 years (range, 19-80 years). The range between the onset of neurologic symptoms and the diagnosis of neuropathy was 2 to 72 months (mean, 13.9 months). The follow-up period ranged from 14 to 94 months (mean, 51.4 months). In 18 patients (35.3{\%}) (16 men and 2 women) whose mean age at diagnosis of neuropathy was 66.5 years, malignant growths were found 3 to 72 months (mean, 27.4 months) after the onset of the neuropathy. The cancer was in the liver in 4 patients (all had a primary hepatoma), the bladder in 3, the lymph nodes in 3 (all with non-Hodgkin lymphoma), the prostate gland in 2, the lungs in 2 (small cell lung cancer in both), the breast in 1, the pancreas in 1, the sublingual gland in 1, and the bone in 1 (a metastatic sarcoma). Conclusions: More than one third of the patients with peripheral sensory neuropathy of unexplained cause developed cancer without any predominating type of malignancy.",
author = "Massimo Camerlingo and Raffaello Nemni and Bruno Ferraro and Luciano Casto and Tania Partziguian and Bruno Censori and Angela Mamoli",
year = "1998",
month = "7",
doi = "10.1001/archneur.55.7.981",
language = "English",
volume = "55",
pages = "981--984",
journal = "Archives of Neurology",
issn = "0003-9942",
publisher = "American Medical Association",
number = "7",

}

TY - JOUR

T1 - Malignancy and sensory neuropathy of unexplained cause

T2 - A prospective study of 51 patients

AU - Camerlingo, Massimo

AU - Nemni, Raffaello

AU - Ferraro, Bruno

AU - Casto, Luciano

AU - Partziguian, Tania

AU - Censori, Bruno

AU - Mamoli, Angela

PY - 1998/7

Y1 - 1998/7

N2 - Objective: To investigate the frequency of cancer developing in patients with peripheral sensory neuropathy of unexplained cause. Design: Prospective study. Setting: A neurologic unit in a general hospital. Methods: Following the diagnosis of neuropathy, we searched for occult malignancy. This search was repeated together with neurologic evaluations every 6 months thereafter. Patient recruitment began January 1, 1988, and ended December 31, 1995. The end point of the study was December 31, l996. Results: In the study period, we observed 363 patients with peripheral sensory neuropathy. Of these, 53 patients without any identified cause of neuropathy were invited to participate in the study. Of the 53, 2 patients refused. Thus, we examined and followed up 51 patients, 42 men and 9 women, with a mean age of 64.5 years (range, 19-80 years). The range between the onset of neurologic symptoms and the diagnosis of neuropathy was 2 to 72 months (mean, 13.9 months). The follow-up period ranged from 14 to 94 months (mean, 51.4 months). In 18 patients (35.3%) (16 men and 2 women) whose mean age at diagnosis of neuropathy was 66.5 years, malignant growths were found 3 to 72 months (mean, 27.4 months) after the onset of the neuropathy. The cancer was in the liver in 4 patients (all had a primary hepatoma), the bladder in 3, the lymph nodes in 3 (all with non-Hodgkin lymphoma), the prostate gland in 2, the lungs in 2 (small cell lung cancer in both), the breast in 1, the pancreas in 1, the sublingual gland in 1, and the bone in 1 (a metastatic sarcoma). Conclusions: More than one third of the patients with peripheral sensory neuropathy of unexplained cause developed cancer without any predominating type of malignancy.

AB - Objective: To investigate the frequency of cancer developing in patients with peripheral sensory neuropathy of unexplained cause. Design: Prospective study. Setting: A neurologic unit in a general hospital. Methods: Following the diagnosis of neuropathy, we searched for occult malignancy. This search was repeated together with neurologic evaluations every 6 months thereafter. Patient recruitment began January 1, 1988, and ended December 31, 1995. The end point of the study was December 31, l996. Results: In the study period, we observed 363 patients with peripheral sensory neuropathy. Of these, 53 patients without any identified cause of neuropathy were invited to participate in the study. Of the 53, 2 patients refused. Thus, we examined and followed up 51 patients, 42 men and 9 women, with a mean age of 64.5 years (range, 19-80 years). The range between the onset of neurologic symptoms and the diagnosis of neuropathy was 2 to 72 months (mean, 13.9 months). The follow-up period ranged from 14 to 94 months (mean, 51.4 months). In 18 patients (35.3%) (16 men and 2 women) whose mean age at diagnosis of neuropathy was 66.5 years, malignant growths were found 3 to 72 months (mean, 27.4 months) after the onset of the neuropathy. The cancer was in the liver in 4 patients (all had a primary hepatoma), the bladder in 3, the lymph nodes in 3 (all with non-Hodgkin lymphoma), the prostate gland in 2, the lungs in 2 (small cell lung cancer in both), the breast in 1, the pancreas in 1, the sublingual gland in 1, and the bone in 1 (a metastatic sarcoma). Conclusions: More than one third of the patients with peripheral sensory neuropathy of unexplained cause developed cancer without any predominating type of malignancy.

UR - http://www.scopus.com/inward/record.url?scp=0031841119&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031841119&partnerID=8YFLogxK

U2 - 10.1001/archneur.55.7.981

DO - 10.1001/archneur.55.7.981

M3 - Article

C2 - 9678316

AN - SCOPUS:0031841119

VL - 55

SP - 981

EP - 984

JO - Archives of Neurology

JF - Archives of Neurology

SN - 0003-9942

IS - 7

ER -