Malignant ascites: Role of the embryological origin of the tumour on ascitic humoral test concentrations

Guido Colloredo Mels, Giorgio Bellati, Gioacchino Leandro, Chiara Perani, Laura Auriemma, Nicola Vacca, Lucio Tiraboschi, Giovanni Angeli, Gaetano Ideo

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: The aim of this study was to investigate the influence of the embryological origin of the tumour on the ascitic humoral test concenrations.Patients: One hundred and twenty-four patients with extra-hepatic malignancy-related ascites were divided into three groups according to the embryological origin of the tumour: Group A (mesoderm) consisted of 52 patients, group B (endoderm) of 55 and group C (ectoderm) of 17.Design: Ascitic fluid (40 ml) was aseptically aspirated and examined routinely for culture by the bedside blood-culture-bottles method for white blood cells, polymorphonuclear ceil count per mm3, malignant cell test and chemistries. Cytological examination was performed within 2 h of ascitic fluid aspiration. Fibronectin, cholesterol, triglycerides, lactic dehydrogenase (LDH), total protein and carcino-embryonic antigen (CEA) ascitic concentrations were determined.Results: The ascitic concentrations of fibronectin, cholesterol, LDH and total protein were significantly higher in group A than in the other two groups, while CEA levels were significantly higher in groups B and C than in A. Triglyceride levels did not differ in the three groups. Factorial analysis of variance showed that malignant cells and embryological origin of the tumour independently influenced ascitic levels of cholesterol, total protein and fibronectin. There was a significant interaction between malignant cells and embryological origin of the tumour for fibronectin whereas CEA and LDH levels were influenced by the embryological origin of the tumour only.Conclusion: This study underlines the role of the oncological histotype on ascitic humoral test concentrations in malignant ascites. In clinical practice, a panel of tests such as cholesterol, LDH and CEA should be used for a suitable diagnostic outcome.

Original languageEnglish
Pages (from-to)251-255
Number of pages5
JournalEuropean Journal of Gastroenterology and Hepatology
Volume5
Issue number4
Publication statusPublished - 1993

Keywords

  • Ascitic tests
  • Malignant ascites

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

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