TY - JOUR
T1 - Malignant epithelial/exocrine tumors of the pancreas
AU - Luchini, Claudio
AU - Grillo, Federica
AU - Fassan, Matteo
AU - Vanoli, Alessandro
AU - Capelli, Paola
AU - Paolino, Gaetano
AU - Ingravallo, Giuseppe
AU - Renzulli, Giuseppina
AU - Doglioni, Claudio
AU - D'Amuri, Alessandro
AU - Mattiolo, Paola
AU - Pecori, Sara
AU - Parente, Paola
AU - Florena, Ada M.
AU - Zamboni, Giuseppe
AU - Scarpa, Aldo
N1 - Publisher Copyright:
Copyright © 2020 Società Italiana di Anatomia Patologica e Citopatologia Diagnostica, Divisione Italiana della International Academy of Pathology.
Copyright:
This record is sourced from MEDLINE/PubMed, a database of the U.S. National Library of Medicine
PY - 2020/9/1
Y1 - 2020/9/1
N2 - Pancreatic malignant exocrine tumors represent the most important cause of cancer-related death for pancreatic neoplasms. The most common tumor type in this category is represented by pancreatic ductal adenocarcinoma (PDAC), an ill defined, stroma-rich, scirrhous neoplasm with glandular differentiation. Here we present the relevant characteristics of the most important PDAC variants, namely adenosquamous carcinoma, colloid carcinoma, undifferentiated carcinoma, undifferentiated carcinoma with osteoclast-like giant cells, signet ring carcinoma, medullary carcinoma and hepatoid carcinoma. The other categories of malignant exocrine tumors, characterized by fleshy, stroma-poor, circumscribed neoplasms, include acinar cell carcinoma (pure and mixed), pancreatoblastoma, and solid pseudopapillary neoplasms. The most important macroscopic, histologic, immunohistochemical and molecular hallmarks of all these tumors, highlighting their key diagnostic/pathological features are presented. Lastly, standardized indications regarding gross sampling and how to compile a formal pathology report for pancreatic malignant exocrine tumors will be provided.
AB - Pancreatic malignant exocrine tumors represent the most important cause of cancer-related death for pancreatic neoplasms. The most common tumor type in this category is represented by pancreatic ductal adenocarcinoma (PDAC), an ill defined, stroma-rich, scirrhous neoplasm with glandular differentiation. Here we present the relevant characteristics of the most important PDAC variants, namely adenosquamous carcinoma, colloid carcinoma, undifferentiated carcinoma, undifferentiated carcinoma with osteoclast-like giant cells, signet ring carcinoma, medullary carcinoma and hepatoid carcinoma. The other categories of malignant exocrine tumors, characterized by fleshy, stroma-poor, circumscribed neoplasms, include acinar cell carcinoma (pure and mixed), pancreatoblastoma, and solid pseudopapillary neoplasms. The most important macroscopic, histologic, immunohistochemical and molecular hallmarks of all these tumors, highlighting their key diagnostic/pathological features are presented. Lastly, standardized indications regarding gross sampling and how to compile a formal pathology report for pancreatic malignant exocrine tumors will be provided.
KW - acinar
KW - pancreatic cancer
KW - pancreatic ductal adenocarcinoma
KW - PDAC
KW - solid pseudopapillary
UR - http://www.scopus.com/inward/record.url?scp=85096081624&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85096081624&partnerID=8YFLogxK
U2 - 10.32074/1591-951X-167
DO - 10.32074/1591-951X-167
M3 - Review article
C2 - 33179623
AN - SCOPUS:85096081624
VL - 112
SP - 210
EP - 226
JO - Pathologica
JF - Pathologica
SN - 0031-2983
IS - 3
ER -