Malignant epithelial/exocrine tumors of the pancreas

Claudio Luchini, Federica Grillo, Matteo Fassan, Alessandro Vanoli, Paola Capelli, Gaetano Paolino, Giuseppe Ingravallo, Giuseppina Renzulli, Claudio Doglioni, Alessandro D'Amuri, Paola Mattiolo, Sara Pecori, Paola Parente, Ada M. Florena, Giuseppe Zamboni, Aldo Scarpa

Research output: Contribution to journalReview articlepeer-review


Pancreatic malignant exocrine tumors represent the most important cause of cancer-related death for pancreatic neoplasms. The most common tumor type in this category is represented by pancreatic ductal adenocarcinoma (PDAC), an ill defined, stroma-rich, scirrhous neoplasm with glandular differentiation. Here we present the relevant characteristics of the most important PDAC variants, namely adenosquamous carcinoma, colloid carcinoma, undifferentiated carcinoma, undifferentiated carcinoma with osteoclast-like giant cells, signet ring carcinoma, medullary carcinoma and hepatoid carcinoma. The other categories of malignant exocrine tumors, characterized by fleshy, stroma-poor, circumscribed neoplasms, include acinar cell carcinoma (pure and mixed), pancreatoblastoma, and solid pseudopapillary neoplasms. The most important macroscopic, histologic, immunohistochemical and molecular hallmarks of all these tumors, highlighting their key diagnostic/pathological features are presented. Lastly, standardized indications regarding gross sampling and how to compile a formal pathology report for pancreatic malignant exocrine tumors will be provided.

Original languageEnglish
Pages (from-to)210-226
Number of pages17
Issue number3
Publication statusPublished - Sep 1 2020


  • acinar
  • pancreatic cancer
  • pancreatic ductal adenocarcinoma
  • PDAC
  • solid pseudopapillary

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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