Malignant fibrous histiocytoma of soft tissue. An analysis of 78 cases located and deeply seated in the extremities

F. Bertoni, R. Capanna, R. Biagini, P. Bacchini, A. Guerra, P. Ruggieri, D. Present, M. Campanacci

Research output: Contribution to journalArticlepeer-review

Abstract

Seventy-eight cases of malignant fibrous histiocytoma (MFH) of soft tissue are reported. All tumors were deeply located in the extremities. An analysis is presented with regard to sex, age, site, macro- and microscopic features. The staging was assessed according to Enneking's classification (IB, one case; IIA, 25 cases; IIB, 42 cases; III, 10 cases). The recurrence rate after surgical treatment was high (37.5%) with significant differences after inadequate surgery (70%), wide excision (38%), or amputation (0%). Adjunctive radiotherapy rarely was effective in preventing local recurrence. The overall 5-year survival rate was 36%. The prognosis was worse in (1) tumors larger than 5 cm in diameter, (2) tumors that recurred early (less than 1 year) after surgery, and (3) tumors that had inadequate surgical treatment (intralesional or marginal excision).

Original languageEnglish
Pages (from-to)356-367
Number of pages12
JournalCancer
Volume56
Issue number2
DOIs
Publication statusPublished - 1985

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Fingerprint Dive into the research topics of 'Malignant fibrous histiocytoma of soft tissue. An analysis of 78 cases located and deeply seated in the extremities'. Together they form a unique fingerprint.

Cite this