Abstract
Purpose: Glomus tumours are characteristically benign solitary tumours. At our knowledge, about 23 reports are present in literature regarding the malignant counterpart, but only a minority developed metastases. We describe a locally aggressive glomus tumour with lymphnode metastasis. Patient: The patient was a 40 year-old man presenting a 1.5-cm lesion on the right wrist incompletely excised and a recurrent tumour, 4 x 2 cm in size, removed after 9 months, for which he received radiotherapy. After 2 years he developed an axillary lymphnode metastasis. Results: Histologically, both tumours (primary and metastasis) were similar. There were sheets and nests of uniform small cells with scant eosinophilic cytoplasm and round to polygonal nuclei; there was some degree of pleomorphism and the mitotic index was high (up to 18m/10 HPF). The tumour cells were positive for vimentin and smooth muscle actin, but negative for desmin, NSR, Factor VIII, chromogranin, cytokeratin. Remarkably, in the primary, the cells strongly expressed p53 (70%) and MIB-1 (35%). Discussions: In many reported malignant cases, the histology of the tumour cells suggested that they were malignant, yet the clinical course has been benign. Carefully reviewing the literature, it seems that actually we have enough histological criteria to identify the cases with biological adverse outcome. Those unfortunate cases behave as high grade sarcomas and therefore may deserve an aggressive therapeutic treatment.
| Original language | English |
|---|---|
| Pages (from-to) | 87-91 |
| Number of pages | 5 |
| Journal | Sarcoma |
| Volume | 7 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Jun 2003 |
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Keywords
- Arm
- Glomus tumour
- Malignant
ASJC Scopus subject areas
- Oncology
Cite this
Malignant glomus tumour : A case report and review of the literature. / De Chiara, Annarosaria; Apice, Gaetano; Mori, Stefano; Silvestro, Giustino; Losito, Simona N.; Botti, Gerardo; Ninfo, Vito.
In: Sarcoma, Vol. 7, No. 2, 06.2003, p. 87-91.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Malignant glomus tumour
T2 - A case report and review of the literature
AU - De Chiara, Annarosaria
AU - Apice, Gaetano
AU - Mori, Stefano
AU - Silvestro, Giustino
AU - Losito, Simona N.
AU - Botti, Gerardo
AU - Ninfo, Vito
PY - 2003/6
Y1 - 2003/6
N2 - Purpose: Glomus tumours are characteristically benign solitary tumours. At our knowledge, about 23 reports are present in literature regarding the malignant counterpart, but only a minority developed metastases. We describe a locally aggressive glomus tumour with lymphnode metastasis. Patient: The patient was a 40 year-old man presenting a 1.5-cm lesion on the right wrist incompletely excised and a recurrent tumour, 4 x 2 cm in size, removed after 9 months, for which he received radiotherapy. After 2 years he developed an axillary lymphnode metastasis. Results: Histologically, both tumours (primary and metastasis) were similar. There were sheets and nests of uniform small cells with scant eosinophilic cytoplasm and round to polygonal nuclei; there was some degree of pleomorphism and the mitotic index was high (up to 18m/10 HPF). The tumour cells were positive for vimentin and smooth muscle actin, but negative for desmin, NSR, Factor VIII, chromogranin, cytokeratin. Remarkably, in the primary, the cells strongly expressed p53 (70%) and MIB-1 (35%). Discussions: In many reported malignant cases, the histology of the tumour cells suggested that they were malignant, yet the clinical course has been benign. Carefully reviewing the literature, it seems that actually we have enough histological criteria to identify the cases with biological adverse outcome. Those unfortunate cases behave as high grade sarcomas and therefore may deserve an aggressive therapeutic treatment.
AB - Purpose: Glomus tumours are characteristically benign solitary tumours. At our knowledge, about 23 reports are present in literature regarding the malignant counterpart, but only a minority developed metastases. We describe a locally aggressive glomus tumour with lymphnode metastasis. Patient: The patient was a 40 year-old man presenting a 1.5-cm lesion on the right wrist incompletely excised and a recurrent tumour, 4 x 2 cm in size, removed after 9 months, for which he received radiotherapy. After 2 years he developed an axillary lymphnode metastasis. Results: Histologically, both tumours (primary and metastasis) were similar. There were sheets and nests of uniform small cells with scant eosinophilic cytoplasm and round to polygonal nuclei; there was some degree of pleomorphism and the mitotic index was high (up to 18m/10 HPF). The tumour cells were positive for vimentin and smooth muscle actin, but negative for desmin, NSR, Factor VIII, chromogranin, cytokeratin. Remarkably, in the primary, the cells strongly expressed p53 (70%) and MIB-1 (35%). Discussions: In many reported malignant cases, the histology of the tumour cells suggested that they were malignant, yet the clinical course has been benign. Carefully reviewing the literature, it seems that actually we have enough histological criteria to identify the cases with biological adverse outcome. Those unfortunate cases behave as high grade sarcomas and therefore may deserve an aggressive therapeutic treatment.
KW - Arm
KW - Glomus tumour
KW - Malignant
UR - http://www.scopus.com/inward/record.url?scp=0041885436&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0041885436&partnerID=8YFLogxK
U2 - 10.1080/1357714031000081207
DO - 10.1080/1357714031000081207
M3 - Article
C2 - 18521375
AN - SCOPUS:0041885436
VL - 7
SP - 87
EP - 91
JO - Sarcoma
JF - Sarcoma
SN - 1357-714X
IS - 2
ER -