Malignant histiocytosis (true histiocytic lymphoma): Clinicopathological study of 25 cases

S. Pileri, P. Mazza, M. T. Rivano, G. Martinelli, G. Cavazzini, M. Gobbi, D. Taruscio, F. Lauria, S. Tura

Research output: Contribution to journalArticle

Abstract

Twenty-five cases originally diagnosed as malignant histiocytosis/true histiocytic lymphoma were reviewed according to both pathological and clinical criteria. Microscopically, they were characterized by large, pleomorphic tumour cells showing variable degrees of atypia and phagocytic activity. The growth more often appeared as diffuse, being limited to the sinuses in only two cases. Cytochemistry on touch imprints showed tumour cells strongly positive for acid phosphatase and α-naphthyl-acetate esterase in all the samples tested. Immunohistochemistry on paraffin embedded sections using specific antisera showed tumour cell positivity for lysozyme in 12 of 25 cases, for α1-antitrypsin in 24 of 25 cases and for α1-antichymotrypsin in all 25 cases. Immunophenotyping on frozen-sections in three cases displayed a clear-cut reactivity of the neoplastic cells with the monoclonal antibody OKM1. Clinically, the disease more often presented with B-symptoms, lymphadenopathy and mediastinal involvement. In the majority of the patients (18/25) it had a fatal and rapid course, despite therapy (median survival: 9 months; mean survival: 12 months). The presence of B-symptoms and bulky disease appeared as the only factors influencing the prognosis, both suggesting a more aggressive course of the tumour.

Original languageEnglish
Pages (from-to)905-920
Number of pages16
JournalHistopathology
Volume9
Issue number9
Publication statusPublished - 1985

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Histiocytic Sarcoma
Neoplasms
Acetylesterase
Immunophenotyping
Histocytochemistry
Survival
Touch
Frozen Sections
Muramidase
Acid Phosphatase
Paraffin
Immune Sera
Immunohistochemistry
Monoclonal Antibodies
Growth

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine
  • Cell Biology

Cite this

Pileri, S., Mazza, P., Rivano, M. T., Martinelli, G., Cavazzini, G., Gobbi, M., ... Tura, S. (1985). Malignant histiocytosis (true histiocytic lymphoma): Clinicopathological study of 25 cases. Histopathology, 9(9), 905-920.

Malignant histiocytosis (true histiocytic lymphoma) : Clinicopathological study of 25 cases. / Pileri, S.; Mazza, P.; Rivano, M. T.; Martinelli, G.; Cavazzini, G.; Gobbi, M.; Taruscio, D.; Lauria, F.; Tura, S.

In: Histopathology, Vol. 9, No. 9, 1985, p. 905-920.

Research output: Contribution to journalArticle

Pileri, S, Mazza, P, Rivano, MT, Martinelli, G, Cavazzini, G, Gobbi, M, Taruscio, D, Lauria, F & Tura, S 1985, 'Malignant histiocytosis (true histiocytic lymphoma): Clinicopathological study of 25 cases', Histopathology, vol. 9, no. 9, pp. 905-920.
Pileri S, Mazza P, Rivano MT, Martinelli G, Cavazzini G, Gobbi M et al. Malignant histiocytosis (true histiocytic lymphoma): Clinicopathological study of 25 cases. Histopathology. 1985;9(9):905-920.
Pileri, S. ; Mazza, P. ; Rivano, M. T. ; Martinelli, G. ; Cavazzini, G. ; Gobbi, M. ; Taruscio, D. ; Lauria, F. ; Tura, S. / Malignant histiocytosis (true histiocytic lymphoma) : Clinicopathological study of 25 cases. In: Histopathology. 1985 ; Vol. 9, No. 9. pp. 905-920.
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