Malignant lymphoproliferative disorders in liver cirrhosis

L. Lombardo, D. Rota Scalabrini, P. Vineis, M. De La Pierre

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Background: Lymphoproliferative disorders in patients with liver cirrhosis, although uncommon, have been reported in at least 49 cases. Some authors have suggested that the association between chronic liver disease and lymphoma is not coincidental, that immune mechanisms may be pathogenetically involved. Patients and methods: In the present study we calculated the incidence rate of lymphoproliferative disorders in 334 liver cirrhosis patients (201 males, mean age 59 ± 12; 133 females, mean age 61 ± 11) treated at the Gastroenterology Department of the Mauriziano Hospital in Turin from January 1987 to September 1990. Results: We diagnosed 12 lymphoproliferative disorders, corresponding to an incidence of 9.56/1,000 person-years, a figure much higher than expected on the basis of the incidence rate registered in the Turin general population. Six of the 12 lymphoproliferative disorders were non-Hodgkin's lymphomas of the stomach, a proportion by far exceeding expectation. Conclusions: Our data support the hypothesis that the association between chronic liver disease and lymphoproliferative disorders is not just coincidental, and suggest that liver cirrhosis might be considered an immunological disturbance which entails an increased risk of developing lymphoproliferative disorders. Mechanisms causing lymphoproliferative disorders to develop in the course of chronic liver disease have been hypothesized.

Original languageEnglish
Pages (from-to)245-250
Number of pages6
JournalAnnals of Oncology
Volume4
Issue number3
Publication statusPublished - Mar 1993

Fingerprint

Lymphoproliferative Disorders
Liver Cirrhosis
Liver
Disorder
Liver Diseases
Incidence
Chronic Disease
Gastroenterology
Non-Hodgkin's Lymphoma
Hospital Departments
Lymphoma
Stomach
Figure
Person
Proportion
Cohort Studies
Disturbance
Population

Keywords

  • Liver cirrhosis
  • Lymphoproliferative disorders

ASJC Scopus subject areas

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Public Health, Environmental and Occupational Health
  • Neuropsychology and Physiological Psychology
  • Hematology
  • Oncology
  • Cancer Research

Cite this

Lombardo, L., Scalabrini, D. R., Vineis, P., & De La Pierre, M. (1993). Malignant lymphoproliferative disorders in liver cirrhosis. Annals of Oncology, 4(3), 245-250.

Malignant lymphoproliferative disorders in liver cirrhosis. / Lombardo, L.; Scalabrini, D. Rota; Vineis, P.; De La Pierre, M.

In: Annals of Oncology, Vol. 4, No. 3, 03.1993, p. 245-250.

Research output: Contribution to journalArticle

Lombardo, L, Scalabrini, DR, Vineis, P & De La Pierre, M 1993, 'Malignant lymphoproliferative disorders in liver cirrhosis', Annals of Oncology, vol. 4, no. 3, pp. 245-250.
Lombardo L, Scalabrini DR, Vineis P, De La Pierre M. Malignant lymphoproliferative disorders in liver cirrhosis. Annals of Oncology. 1993 Mar;4(3):245-250.
Lombardo, L. ; Scalabrini, D. Rota ; Vineis, P. ; De La Pierre, M. / Malignant lymphoproliferative disorders in liver cirrhosis. In: Annals of Oncology. 1993 ; Vol. 4, No. 3. pp. 245-250.
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