Malignant Melanoma Developing in an Area of Hereditary Palmoplantar Keratoderma (Mal De Meleda)

Nicola Mozzillo, Carmine A. Nunziata, Corrado Caracò, Flavio Fazioli, Gerardo Botti

Research output: Contribution to journalArticle


Palmoplantar keratoderma (PPK) refers to a genetically heterogeneous group of skin diseases, which may be inherited in autosomal dominant or recessive fashion. We observed a case of a 74-year-old man with Mal de Meleda, who developed malignant melanoma inside the hyperkeratotic palmar skin of the right hand. Many authors have reported a higher incidence of cancer in cases affected by palmoplantar hyperkeratosis both for hereditary association and particularly for mechanical damage of the affected areas. The association with melanoma has already been described, but not in a true Mal de Meleda type syndrome as in the case reported in this paper.

Original languageEnglish
Pages (from-to)229-233
Number of pages5
JournalJournal of Surgical Oncology
Issue number4
Publication statusPublished - Dec 2003



  • Keratoderma palmoplantaris
  • Mal de Meleda
  • Malignant melanoma
  • Recessive transgressive palmoplantar keratoderma

ASJC Scopus subject areas

  • Surgery
  • Oncology

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